ReviewSingle nucleotide polymorphism in genome-wide association of human population: A tool for broad spectrum service

Genome-wide patterns of variation across individuals provide most powerful source of data for uncovering the history of migration, expansion, and adaptation of the human population. The arrival of new technologies that type more than millions of the single nucleotide polymorphisms (SNPs) in a single experiment has made SNP in genome-wide association (GWA) assay a prudent venture. SNPs represent the most widespread type of sequence variation in genomes, and known as valuable genetic markers for revealing the evolutionary history and common genetic polymorphisms that explain the heritable risk for common diseases. Characterizing the nature of gene variation in human populations and assembling an extensive catalog of SNPs in candidate genes in association with particular diseases are the major goals of human genetics. In this article we explore the recent discovery of SNP–GWA to revolutionize not only the process of genetic variation and disease detection but also the convention of preventative and curative medicine for future prospects.Keywords: SNPs; Genetic variation; Human population; Disease risk; Drug developmentThe Egyptian Journal of Medical Human Genetics (2013) 14, 123–13

Human resource professionals’ effectiveness, organizational culture and high performance work system link: evidence from Pakistan

HR professionals’ effectiveness is widely discussed as the most significant factor within the organization to gain sustainable competitive advantage at the present time.Nonetheless, the study investigates the impact of organizational culture on HR professionals’ effectiveness in telecom sector of Pakistan.Moreover, it also examines the moderating role of high performance work system in above mentioned correlation.A total of 75 survey questionnaires were distributed to HR managers of telecom firms, out of which 40 HR manager responded which makes 53.3% response rate.The study has used SmartPLS 3 for the assessment of the hypothesized model.The statistical results have established the strong positive effect of organizational culture on HR professionals’ effectiveness, however, findings reveal high performance work system doesn’t moderate this relationship.The study concludes organizations with strong organizational culture can achieve sustainable competitive advantage by augmenting HR professionals’ effectiveness, moreover, organizations have to align their HR strategies with robust HR system which can enhance HR professionals’ effectiveness.The findings of the study are of a great value to both theory and practice and have vital implications for academicians, practitioners and policy makers

N.I.T (New Ideas Technology): glove marker / Mohd Fakhrunabil Mohd Fareed [et al.]

Our company named New Idea Technology just been established in Malaysia as a company which aims to improve household items to achieve as maximum potential. We have found an innovative way to provide higher efficiency in learning session by introducing "glove marker" to the market

THE OBLIGATION TO PROSECUTE HEADS OF STATE UNDER THE ROME STATUTE OF THE INTERNATONAL CRIMINAL COURT (ICC) AND CUSTOMARY INTERNATIONAL LAW: THE AFRICAN AND U.S. PERSPECTIVES

The United States (US), a Signatory, but not a State Party, to the Rome Statute, entered into various Bilateral Agreements (BIAs) with almost all Rome Statute State Parties prohibiting the arrest, surrender, or prosecution of the U.S. Head of State before the ICC. Similarly, the African Union (AU) Members, being the majority State Parties to the Rome Statute have decided in the AU Assembly of Heads of State and Government not to cooperate with the ICC and to grant immunity to African Heads of State after the ICC Pre-Trial Chamber issued two arrest warrants against the Sudanese President for allegedly committing genocide, crimes against humanity and war crimes. This paper examines the tension between States’ obligations under the Rome Statute to prosecute, surrender and arrest a head of State, including when referred to by the UN Security Council on the one hand, and the AU decision, the US BIAs and customary international law which grants immunity to a sitting head of State from criminal prosecution by either an international or a foreign court on the other hand. It argues that States are bound by the obligations enshrined under the Rome Statute and both the AU decision and the BIAs are inconsistent with the duty of states to uphold jus cogens norms including those proscribed under the Rome Statue 2002. &nbsp

Strength Performance of Blended Ash Based Geopolymer Mortar

Geopolymer is a based on inorganic alumino-silicate binder system. Geopolymeric materials are formed using materials that containing silica and aluminium such as fly ash and rice husk ash, which activated by alkaline solution. This paper presents the study on the effect of replacement of SSA in RHA based geopolymer, types of curing and different molarity of NaOH used on the strength of Sewage Sludge Ash (SSA) and Rice Husk Ash (RHA) based geopolymer mortar incorporating with three (3) different mix proportions. Based geopolymer mortar was synthesized from treated sewage sludge and rice husk undergoing incineration process in producing ashes, activated with sodium silicate and sodium hydroxide solution by ratio of 2.5:1 and solution to ash ratio of 1:1. Molarity of 8M and 10M NaOH were used. The percentages of SSA replacement were 0%, 10% and 20% by weight. Compressive strength was conducted at age 7, 14 and 28 days to see the development of strength with two curing regimes, which are air curing and oven curing (60°C for 24 hours). From the research conducted, the ultimate compressive strength (6.28MPa) was obtained at zero replacement of SSA taken at 28 days of oven curing with 10M of NaOH. This shows that RHA, which is rich in silica content is enough to enhance the strength of geopolymer mortar especially with high molarity of NaOH

Channel Impulse Response Equalization based on Genetic Algorithm in Mode Division Multiplexing

This paper proposed to use genetic algorithm (GA) as an adaptive algorithm for mode division multiplexing (MDM) equalization in order to minimize the mean square error as well as to maximize the similarity between the ideal signal and the MDM distorted signal. A significant result has been obtained of implementing GA on MDM equalization compared to other conventional algorithm such as least mean square (LMS) which is used dominantly in current equalizations

Performance management system (PMS) as a predictor of employee performance of private bank managers in (Pakistan)

The aim of this study is to explore the influence of Performance Management System (PMS) on managers’ performance of Meezan bank in Lahore (Pakistan).PMS is mostly undertaken to let management know the performance of employees since employees’ performance is one of the considerable issues for the organizations in this competitive world.A total of 115 survey questionnaires were distributed through mail to the managers of Meezan bank using simple random sampling and 61 responses were returned which makes 53% response rate. Instrument was developed by the researchers with the help of HRM experts and initially pilot test was done to test the reliability of the instrument which showed all alpha values were greater than 0.80.Pearson correlation, linear regression, mean and S.D techniques were used to check the relationship between predictors and dependent variable.According to findings, all the predictors “job dimension, clear goals and objectives, performance appraisal system and rewards and recognition” have significant relationship with performance of managers of Meezan bank (Lahore).It is proposed that top management of Meezan bank should considerably look at the formal implementation of the PMS for sustaining competitive advantage

A Review on Potential use of Coal Bottom Ash as a Supplementary Cementing Material in Sustainable Concrete Construction

The demand of concrete is increased rapidly due to worldwide growth in infrastructural development. Consequently, consumption of concrete also raises the demand for Portland cement, because it is the fundamental material in concrete construction. The increasing demand for Portland cement is expected to be encountered by introducing new supplementary cementing materials. Considering the sustainability of construction, it is imperative to develop supplementary cementing materials from the industrial waste by-products; one of such waste is the coal bottom ash, produced by coal-based thermal power plants. Previously several studies have been conducted on the utilization of coal bottom ash in its original form as natural sand replacement but limited research has been reported on the coal bottom ash as replacement of cement. It was observed through the literature review that the original coal bottom ash is porous in nature, and cannot be used as a replacement of cement, but after the proper grinding, it possesses the good pozzolanic property and could be utilized as replacement of cement in concrete. The result of this review has indicated that ground coal bottom ash has a good potential to be utilized as supplementary cementing materials in concrete construction. The aim of this review is to summarize the previous findings on the utilization of coal bottom ash as supplementary cementing materials in concrete construction. Hence, this article will deliver the key information and valuable material for the researchers looking for the supplementary cementing materials in the field of advanced concrete technology

The importance of Person-Job (PJ)fit and personorganization (PO) fit employee selection and hiring among Malaysian graduates: Evidence from Malaysian private organizations

This study explored the perceived importance of person-job fit and person-organization fit in relation with employee hiring and selection in Malaysian private organizations.The purpose of this paper is to propose a contingency perspective that describes the relative importance of person-job (PJ) fit and person-organization (PO) fit as selection criteria for hiring various types of employees.This study further identifies the antecedents of PJ and PO fit as practiced by Malaysian private organizations.The other important aim of the study is to examine the consequences of PJ and PO fit in employee selection and hiring, and also develop an initial PJ and PO fit model in the context of Malaysian environment as well.A qualitative field study was then carried out to explore the perceptions of person-job (PJ) fit and person-organization (PO) fit in employee hiring and selection in the Malaysian private organizations. The findings from the qualitative study and literature review were then to develop initial research model.Ten Malaysian private organizations of various sizes are studied via interviews with key personnel.The results of the study identify twelve variables as antecedents of PJ and PO fit in hiring and selecting employees. The paper will also contribute theoretically and practically by providing an initial model of PJ and PO fit for the private organizations in the Malaysian environment. The implications and future directions of the study are also discusse

Psychometric evaluation of the Malay version of the Impact of Weight on Quality of Life-Lite (IWQOL-LITE) questionnaire

Introduction The availability of obesity specific quality of life measurement tool is limited. The Malay version of Impact of Weight on Quality of Life-Lite is an obesity specific quality of life questionnaire which has been translated for use in Malaysia. The aim of this study is to evaluate the validity and reliability of this questionnaire to measure quality of life among different body mass index (BMI) groups. Methods One hundred and twenty subjects with different BMI categories who attended an outpatient government clinic were recruited for this study. The translated Malay version of IWQOL-Lite was used to assess the impact of weight on quality of life of respondents. Content validity, criterion validity and construct validity were used to assess the questionnaire validity while internal consistencies and test-retest reliability were used to assess the questionnaire reliability. Results The Malay version of IWQOL-Lite showed good psychometric properties. The content validity was agreed upon by expert panels. The mean score of all IWQOL-Lite domains were able to discriminate between different BMI groups. Good internal consistency was demonstrated by Cronbach alpha of 0.936. Test-retest reliability ranged from 0.828 to 0.932. The physical function score (IWQOL-Lite) correlated positively with Physical Component Summary of Short Form-36 questionnaire. Exploratory factor analysis found that the questions loaded on their respective five domains. Conclusions The results suggested that the Malay version of IWQOL-Lite is a valid and reliable tool to measure quality of life among obese and overweight subjects in Malaysia