391 research outputs found

    Frequency Coded Chipless RFID Tag using Spurline Resonators

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    A novel compact chipless RFID tag using spurline resonators is discussed in this paper. The detection of the tag's ID is using the spectral signature of a spurline resonator circuit. The tag has a data capacity of 8-bits in the range 2.38 to 4.04 GHz. The tag consists of a spurline multiresonating circuit and two cross polarised antennas. The prototype of the tag is fabricated on a substrate C-MET/LK4.3 of dielectric constant 4.3 and loss tangent 0.0018. The measured results show that group delay response can also be used to decode the tag’s identity

    Production technology of coir pith cake formulation of Trichoderma harzianum

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    Low cost formulations and delivery system are necessary for wide adoption of bio-control of plant diseases using microbial antagonists. Though several plantation crops wastes/by-products including coir pith are used for multiplication of Trichoderma species, no attempt has been made so far to develop a low cost commercial product with long shelf life and high population of antagonist. A technology has been developed to prepare a commercial product viz., Trichoderma coir pith cake (TCPC) using ‘maida’ flour and Trichoderma harzianum biomass. It has been found that dried TCPC packed in polythene bags can be stored at room temperature (26-30 °C) for 10 months with high level of T. harzianum population. Through a simple activation process of moistening the dried TCPC and incubating under room temperature for 2 days, luxurious growth of Trichoderma covering the entire product was obtained and thus the population could be increased to a very high level. Mean T. harzianum population in dry TCPC after 10 months of storage was found to be 5.0x106 CFU g–1 which has increased to 14.4x106 CFU g-1 on activation. Though the population after one year could be increased from 1.6x106 CFU g-1 in dry TCPC to 5.2x106 in activated, it is ideal to recommend a shelf life period of 10 months while commercializing the product. The new, simple and low cost technology developed, thus, clearly indicates that coir pith, a waste from coconut industry can be made into value added and environment friendly commercial product for management of plant diseases. Several such products can be commercially prepared for different microbial bioagents following this production technology

    Group farming for sustainable aquaculture

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    Sustainable farming is a critical issue in aquaculture development. The concept is well understood but the issue is that of methodology for implementing it. It is well recognized that fragmented holdings have been a major constraint in the implementation of farming practices by small-scale farmers. In India 80 per cent of the shrimp production comes from small and marginal holdings which follow different systems of production, including the traditional ‘pokkali’ farms of Kerala state, improved traditional farming, and scientific methods. Group farming, which was highly successful in paddy farming, was tested among small-scale shrimp farmers practicing paddy and shrimp farming in rotation in a cluster of ‘pokkali’ fields in Kerala. The model served as an effective extension intervention to educate farmers on sustainability while helping them to improve their farming practices. The farmers, including women, could be equipped with the technology for farming not only shrimp but also finfish, crab and aquaculture feed production by strengthening the farmer–extensionist–researcher–political–administrative linkages. The work was done during 1993–1996 at the Central Marine Fisheries Research Institute, Cochin, India. The study formed a part of the action research project on empowerment of rural communities through extension

    EXPLORING VISCERAL ADIPOSITY INDEX AS A PREDICTOR OF VISCERAL ADIPOSITY DYSFUNCTION AND EVALUATING ITS PERFORMANCE IN PREDICTING HEPATIC INSULIN RESISTANCE IN INDIAN TYPE 2 DIABETICS

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    Objective: Visceral adiposity index (VAI) is a simple clinical algorithm developed as a surrogate marker for characterizing visceral adiposity dysfunction (VAD). This study aimed to explore an optimal VAI cut off value for predicting VAD as reflected quantitatively by magnetic resonance imaging (MRI) and to evaluate its merit in predicting the severity of the cardiometabolic risk (CMR) in type 2 diabetic patients of India.Methods: Data was collected from 81 diabetics and 48 healthy participants, who underwent metabolic assessments. VAI derived using BMI, waist circumference (WC), triglycerides (TG) and HDLc, was studied against visceral fat area measuring ≥130 cm2 by MRI as it is associated with higher CMR through raised VAD. Optimal VAI cutoff was determined using the area under the receiver operator characteristic curve (AUROC). Diabetic participants were divided into VAD absent, and VAD present groups based on derived VAI cut off to study associated difference in their metabolic profile. Results: Diabetic group had significantly deranged metabolic profile compared to the healthy control group. Most of the diabetic group participants had a visceral fat area between 101 and 200 cm2. From the ROC curve analysis (AUROC = 0.761), VAI cut-off of 2.0 predicted VAD with sensitivity and specificity of 73.21% and 71.23% respectively. Diabetic participants with VAI values more than 2, had significantly (p<0.05) higher WC, visceral fat, fasting insulin, HOMA-IR (Homeostatic model assessment for insulin resistance), TG (p<0.01), non-HDLc and apolipoprotein B/A1 ratio values. Age adjusted partial correlation analysis showed a significant (p<0.01) positive correlation between VAI and HOMA-IR.Conclusion: VAI was useful in predicting VAD and identifying the severity of CMR within type 2 diabetics. VAI can replace imaging procedures with the advantages of reduced economic burden and can be used as screening tool for surveillance of CMR in Indian population.Â

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    Not AvailableGillnets are commonly used in inland lakes due to their simplicity in construction and operation, efficiency, and low energy usage. The Vembanad lake is one of the most prominent lakes in Kerala, contributing significantly to the small-scale and artisanal fisheries, in which gillnets are the predominant gear. There have been studies on the effect of gillnet panel colour on the selective capture of fish species, primarily in the open ocean and rivers. Although a considerable number of studies exist on the species profile and fish catching methods in the lake, the efficiency of coloured webbing for gillnets is not available. The efficiency of coloured webbing for gillnets is not documented, which, if available, would be a crucial input for implementing gearbased technical measures for conservation in gillnets in the lake. In this regard, a study was conducted along Vembanad lake and the lower reaches of the Muvattupuzha river to compare the catch efficiency and species profile of transparent gillnets typically employed in the region with gillnets fabricated using blue and green coloured webbing. The results demonstrated a considerable increase in CPUE for green-coloured gillnets (708.9±12.8 grams per operation) compared to blue and transparent gillnets, which had CPUE values of 397.9±80.2 and 293.7±70.6 grams per operation, respectively. Significantly higher catches of Horabagrus brachysoma and Etroplus suratensis were obtained with the green-coloured gillnets than with the control (Transparent). Lengthwise data showed that green-coloured nets captured larger individuals of E. suratensis, but significant difference was not observed in other species. The number of E. suratensis captured in each gillnet contributed to the most dissimilarity in all comparisons, followed by Gerres sp. and H. brachysoma, according to similarities percentage analysis conducted to comprehend the species assemblage structure. This is the first report on the effect of gillnet colour on the catch efficiency of gillnets in Vembanad lake, and the results, which indicate species-specific differences in capture, will be one of the many inputs necessary for implementing gear-based technical measures in the gillnet fishery in the lake.Not Availabl

    Effect of doping on the dielectric properties of cerium oxide in the microwave and far-infrared frequency range

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    Cerium oxide (CeO2) has been prepared as a ceramic dielectric resonator by a conventional solid-state ceramic route. The sintered CeO2 has a high dielectric quality factor (Q×f), Q value of 10 000 at 6 GHz with a relative permittivity (ε′) of 23, and temperature coefficient of resonant frequency (τf of -53 ppm/°C. The Q value increases to 20 000 at 6 GHz when the CeO2 is doped with 1 mol% CaCO3. Higher levels of CaCO3 doping lowers the Q and ε′ values and simultaneously decreases τf. TiO2 doping decreases τf and slightly increases ε′, but deceases the Q value. The Q value of pure CeO2 increases to 105 000 at a frequency of 5.58 GHz when it is cooled to 30 K, whereas Q ≈ 85 000 at 5.48 GHz for 1-mol%-CaCO3-doped CeO2 at 30 K

    Identification of PADI2 as a potential breast cancer biomarker and therapeutic target.

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    BACKGROUND: We have recently reported that the expression of peptidylarginine deiminase 2 (PADI2) is regulated by EGF in mammary cancer cells and appears to play a role in the proliferation of normal mammary epithelium; however, the role of PADI2 in the pathogenesis of human breast cancer has yet to be investigated. Thus, the goals of this study were to examine whether PADI2 plays a role in mammary tumor progression, and whether the inhibition of PADI activity has anti-tumor effects. METHODS: RNA-seq data from a collection of 57 breast cancer cell lines was queried for PADI2 levels, and correlations with known subtype and HER2/ERBB2 status were evaluated. To examine PADI2 expression levels during breast cancer progression, the cell lines from the MCF10AT model were used. The efficacy of the PADI inhibitor, Cl-amidine, was tested in vitro using MCF10DCIS cells grown in 2D-monolayers and 3D-spheroids, and in vivo using MCF10DCIS tumor xenografts. Treated MCF10DCIS cells were examined by flow-cytometry to determine the extent of apoptosis and by RT2 Profiler PCR Cell Cycle Array to detect alterations in cell cycle associated genes. RESULTS: We show by RNA-seq that PADI2 mRNA expression is highly correlated with HER2/ERBB2 (p = 2.2 x 106) in luminal breast cancer cell lines. Using the MCF10AT model of breast cancer progression, we then demonstrate that PADI2 expression increases during the transition of normal mammary epithelium to fully malignant breast carcinomas, with a strong peak of PADI2 expression and activity being observed in the MCF10DCIS cell line, which models human comedo-DCIS lesions. Next, we show that a PADI inhibitor, Cl-amidine, strongly suppresses the growth of MCF10DCIS monolayers and tumor spheroids in culture. We then carried out preclinical studies in nude (nu/nu) mice and found that Cl-amidine also suppressed the growth of xenografted MCF10DCIS tumors by more than 3-fold. Lastly, we performed cell cycle array analysis of Cl-amidine treated and control MCF10DCIS cells, and found that the PADI inhibitor strongly affects the expression of several cell cycle genes implicated in tumor progression, including p21, GADD45alpha, and Ki67. CONCLUSION: Together, these results suggest that PADI2 may function as an important new biomarker for HER2/ERBB2+ tumors and that Cl-amidine represents a new candidate for breast cancer therapy
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