Hypertext transfer protocol performance analysis in traditional and software defined networks during Slowloris attack

The extensive use of the internet has resulted in novel technologies and protocol improvisation. Hypertext transfer protocol/1.1 (HTTP/1.1) is widely adapted on the internet. However, HTTP/2 is found to be more efficient over transport control protocol (TCP). The HTTP/2 protocol can withstand the payload overhead when compared to HTTP/1.1 by multiplexing multiple requests. However, both the protocols are highly susceptible to application-level denial of service (DoS) attacks. In this research, a slow-rate DoS attack called Slowloris is detected over Apache2 servers enabled with both versions of HTTP in traditional networks and software defined networks (SDN). Server metrics such as server connection time to the webpage, latency in receiving a response from the server, page load time, response-response gap, and inter-packet arrival time at the server are monitored to analyze attack activity. A Monte Carlo simulation is used to estimate threshold values for server connection time and latency for attack detection. This work is implemented in a lab environment using virtual machines, Ryu controller, zodiac FX OpenFlow switch and Apache2 servers. This study also highlights SDN's security benefits over traditional networks

DAPSONE INDUCED DRESS: A CASE REPORT

Drug reaction with eosinophilia and systemic symptoms. is a very dangerous adverse drug effect causing rashes, eosinophilia, and multiple organ damage. Many drugs are implicated in causing DRESS with most common ones being antimicrobials and antiepileptics. Dapsone used in the treatment of Hansen's disease as a first-line agent is known for causing many side effects ranging from nausea, vomiting, insomnia, anaphylaxis, hypersensitivity reactions, rashes, muscle weakness, abdominal pain, and so on. Hence, we report a rare case of dapsone-induced DRESS in a tertiary care hospital in South India.Â

IDENTIFYING ENTERPRISE RISK BASED ON BUSINESS CONTEXT WITH THREAT INTELLIGENCE

Presented herein are techniques that facilitate prioritizing risk mitigation efforts for business-critical services and transactions through the incorporation of a business context into threat intelligence scoring. Under aspects of the presented techniques, traditional threat intelligence tools may be employed to evaluate the risk that is associated with an enterprise asset; the results of such an evaluation may then be augmented with an enterprise-assigned business value for the asset to derive the asset’s business risk; and such a business risk may be leveraged to prioritize risk mitigation efforts, may be combined with other business risks, etc. The above-described process may be referred to herein as Business Risk Management (BRM)

ASSESSING RISK INTRODUCED THROUGH A CODE CHANGE

Techniques are presented herein that shift the risk assessment focus during a software development process, away from the traditional end-of-process review (when a new feature is delivered, or an application is deployed) to earlier in the process when developers are actively at work. Such an approach allows a developer to assess the risk that a candidate software change is about to introduce prior to the developer committing that change, providing the developer with time (during the early portion of the process) to revisit the software and eliminate the identified risk. Aspects of the presented techniques leverage elements of a continuous integration (CI) and continuous deployment (CD) facility, the results that are available from existing unit and end-to-end tests, and the collection and analysis of OpenTelemetry (OTEL)-based metrics, events, logs, and traces (MELT) data to deliver security insights

Conservation of biological control and bioscavenging: in Rugose Spiralling Whitefly management in coconut

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Synthesis and in vitro evaluation of hydrazinyl phthalazines against malaria parasite, Plasmodium falciparum.

In this report, we describe the synthesis of 1-(Phthalazin-4-yl)-hydrazine using bronsted acidic ionic liquids and demonstrate their ability to inhibit asexual stage development of human malaria parasite, Plasmodium falciparum. Through computational studies, we short-listed chemical scaffolds with potential binding affinity to an essential parasite protein, dihydroorotate dehydrogenase (DHODH). Further, these compounds were synthesized in the lab and tested against P. falciparum. Several compounds from our library showed inhibitory activity at low micro-molar concentrations with minimal cytotoxic effects. These results indicate the potential of hydralazine derivatives as reference scaffolds to develop novel antimalarials

Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)

Epidemiological studies have shown an inverse correlation between the incidence of lymphatic filariasis (LF) and the incidence of allergies and autoimmunity. However, the interrelationship between LF and type-2 diabetes is not known and hence, a cross sectional study to assess the baseline prevalence and the correlates of sero-positivity of LF among diabetic subjects was carried out (n = 1416) as part of the CURES study. There was a significant decrease in the prevalence of LF among diabetic subjects (both newly diagnosed [5.7%] and those under treatment [4.3%]) compared to pre-diabetic subjects [9.1%] (p = 0.0095) and non-diabetic subjects [10.4%] (p = 0.0463). A significant decrease in filarial antigen load (p = 0.04) was also seen among diabetic subjects. Serum cytokine levels of the pro-inflammatory cytokines—IL-6 and GM-CSF—were significantly lower in diabetic subjects who were LF positive, compared to those who were LF negative. There were, however, no significant differences in the levels of anti-inflammatory cytokines—IL-10, IL-13 and TGF-β—between the two groups. Although a direct causal link has yet to be shown, there appears to be a striking inverse relationship between the prevalence of LF and diabetes, which is reflected by a diminished pro-inflammatory cytokine response in Asian Indians with diabetes and concomitant LF

Environmental Disaster Education at University: An Overview in New Normal of COVID-19

Pandemic Coronavirus Disease (COVID-19) is a non-natural disaster that occurs globally. Disaster mitigation efforts need to be made when entering a new normal life after the physical distancing policy is relaxed. The purpose of this study was to describe the knowledge and participation of students in disaster mitigation activities during the new normal period. The research method used descriptive, data collection techniques through Google Form with a sample of 54 students. The results showed that learning of disaster mitigation education is not maximally taught at the university level with a percentage of 57.4% for students, who did not receive disaster mitigation education. However, as many as 51.9% of students had attended training in disaster education. Disaster mitigation education was important to do when a new normal period. That is because students are one component that has a role to convey various information about the disaster, especially COVID-19. This study concludes that knowledge and student participation in disaster education still needs to be improved. The suggestion from this research was necessary to develop innovative learning tools for disaster mitigation education in the new normal era of COVID-19

Novel Interactome of \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e Myosin Type II Identified by a Modified Integrated Membrane Yeast Two-Hybrid (iMYTH) Screen

Nonmuscle myosin type II (Myo1p) is required for cytokinesis in the budding yeast Saccharomyces cerevisiae. Loss of Myo1p activity has been associated with growth abnormalities and enhanced sensitivity to osmotic stress, making it an appealing antifungal therapeutic target. The Myo1p tail-only domain was previously reported to have functional activity equivalent to the full-length Myo1p whereas the head-only domain did not. Since Myo1p tail-only constructs are biologically active, the tail domain must have additional functions beyond its previously described role in myosin dimerization or trimerization. The identification of new Myo1p-interacting proteins may shed light on the other functions of the Myo1p tail domain. To identify novel Myo1p-interacting proteins, and determine if Myo1p can serve as a scaffold to recruit proteins to the bud neck during cytokinesis, we used the integrated split-ubiquitin membrane yeast two-hybrid (iMYTH) system. Myo1p was iMYTH-tagged at its C-terminus, and screened against both cDNA and genomic prey libraries to identify interacting proteins. Control experiments showed that the Myo1p-bait construct was appropriately expressed, and that the protein colocalized to the yeast bud neck. Thirty novel Myo1p-interacting proteins were identified by iMYTH. Eight proteins were confirmed by coprecipitation (Ape2, Bzz1, Fba1, Pdi1, Rpl5, Tah11, and Trx2) or mass spectrometry (AP-MS) (Abp1). The novel Myo1p-interacting proteins identified come from a range of different processes, including cellular organization and protein synthesis. Actin assembly/disassembly factors such as the SH3 domain protein Bzz1 and the actin-binding protein Abp1 represent likely Myo1p interactions during cytokinesis

Green Synthesis of Silver Nanoparticles using Litsea glutinosa L. Leaves and Stem Extracts and their Antibacterial Efficacy

The present study explores the green approach for the preparation of silver nanoparticles (AgNPs) through the reduction of silver nitrate by the cell-free stem and leaf aqueous extracts of Litsea glutinosa (L.glutinosa) and its potential antibacterial activity. The analytical instruments include scanning electron microscopy, Fourier transforms infrared spectroscopy, UV-visible spectroscopy, and X-ray diffraction spectroscopy confirmed the synthesis of smaller, uniformly spherical AgNPs (10-40 nm). The average crystalline size of prepared AgNPs produced by L. glutinosa leaf extract was found to be 19 mm. From UV-visible spectral analysis, the maximum absorbance peak appeared at 444 nm for leaf extract AgNPs different from stem extract AgNPs (422 nm), which are found to be specific for AgNPs. The L.glutinosa stem extract-assisted AgNPs have shown significant antibacterial activity against Bacillus subtilis (Gram-positive) and Escherichia coli (Gram-negative) in comparison to Gentamycin. Hence, the AgNPs obtained by green synthesis can be therapeutically explored against bacterial infections