Scrotal cavernous hemangioma presented with pruritus in a teenager: A case report

Key Clinical Message Ulcerated scrotal cavernous hemangioma is uncommon and rarely presents with pruritus. The surgeon should perform a complete scrotal examination, choose the best treatment option, and the diagnosis should be confirmed histopathologically. Abstract Ulcerated scrotal hemangiomas are a rare disease that can pose a diagnostic challenge, particularly if there is simultaneous hemorrhage. We report the case of a 12‐year‐old child with an unusual presentation of scrotal cavernous hemangioma characterized by itching and bleeding. The mass was surgically removed, and the diagnosis was confirmed histopathologically

Evaluating the Effect of Staple Line Reinforcement on Reducing the Complications of Laparoscopic Sleeve Gastrectomy: A Randomized Clinical Trial

Laparoscopic sleeve gastrectomy (LSG) is the most common bariatric surgery technique. In this technique, bleeding and staple line the leakage is considered as the most important complications. The current study aimed at evaluating the effect of reinforced the taple line on the level of bleeding and leakage after the surgery. Overall, 199 patients meeting the eligible criteria with morbid obesity (BMI>40 kg/m2) were enrolled in the study after signing the written informed consent. Patients were randomly allocated to intervention group (with reinforced staple line) and control group (Standard treatment) using simple randomization technique. Out of 199 cases, 120 (60%) were female, and 80 (40%) male; their mean BMI was 44.79± kg/m2, ranging from 40 to 58 kg/m2. Staple site bleeding was observed; therefore, no significant relationship was observed between the groups regarding bleeding decrease. Staple line leakage was observed in 2 cases of the control (without reinforcement) group and none of the cases in the intervention (with reinforcement) group. According to the results of the current study, no statistically significant relationship was observed between the groups regarding the level of leakage (P=0.249). Also, there was no significant relationship between age, gender, and BMI of cases, and the level of bleeding and leakage from the staple site. The average duration of surgery was 52.03 and 69.64 minutes for the control and intervention groups, respectively, which indicated prolonged surgery in the intervention group (P<0.001). The current study results indicated no significant relationship between the groups regarding the level of bleeding and leakage from the staple site

Effect of flaxseed supplementation on markers of inflammation and endothelial function: A systematic review and meta-analysis

Objectives: The rationale for the current study was to evaluate the efficacy of flaxseed supplementation on important adhesion molecules and inflammatory cytokines in adults. Methods: We conducted searches of published literature in PubMed, Scopus, Web of Science, and Google Scholar databases from inception until May 2019. All randomized controlled trials (RCTs) which investigated the effects of flaxseed supplementation on the circulating concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), vascular cell adhesion protein 1 (VCAM-1), E-selectin, and intercellular adhesion molecule 1 (ICAM-1) were included in our analysis. Results were summarized using weighted mean differences (WMDs) by random-effects model. Results: Forty eligible RCTs, including 2520 participants were identified. The results of the meta‐analysis revealed flaxseed supplementation reduced the concentrations of CRP (WMD = −0.387 mg/L; 95% CI: −0.653, −0.121, p = 0.004), IL-6 (WMD = −0.154 pg/Ml; 95% CI: −0.299, −0.010, p = 0.036), and VCAM-1 (WMD = –22.809 ng/ml; 95% CI: −41.498, −4.120, p = 0.017) but had no significant effect on TNF-α (WMD = -0.077 pg/mL; 95% CI: −0.317, 0.163, p = 0.530), ICAM-1 (WMD = −8.610 ng/ml; 95% CI: −21.936, 4.716, p = 0.205), and E-selectin (WMD = −1.427 ng/ml; 95% CI: −4.074, 1.22, p = 0.291). Conclusions: These findings showed that flaxseed supplementation may improve some circulating concentrations of specific adhesion molecules and inflammatory cytokines. However, well-designed trials are needed to confirm the range of non-significant and/or equivocal findings