The Impact of Traditional Medicine-Based Lifestyle and Diet on Infertility Treatment in Women Undergoing Assisted Reproduction: A Randomized Controlled Trial

The problem of infertility is growing rapidly in the world. Traditional medicine with thousands of years of history has claimed that it can treat some kinds of infertility using nutritional and lifestyle modifications and interventions. The purpose of this study was to evaluate the effect of a traditional medicine-oriented diet and lifestyle on infertility treatment. Based on a clinical trial study, 180 infertile women who were 20-40 years old and candidates for in vitro fertilization (IVF) were randomly assigned to 2 groups: An intervention group and a control group. The intervention group used diet and lifestyle recommendations based on Iranian traditional medicine for at least 3 months. The number of ova, mature ovum number, embryo number, embryo quality, and fertilization rate were significantly higher in the intervention group than in the control group (for all items; p < 0.05). Overall pregnancy rate was significantly higher in the intervention group (35.2 vs. 12.4; odds ratio OR, 3.8; 95% CI, 1.8-8.3). The intervention group had a higher rate of getting spontaneous pregnancy than the control group (20.9 vs. 2.2%; OR, 11.5; 95% CI, 2.6-50.9). Chemical pregnancy was significantly higher in the intervention group (64 vs. 27.5%; OR, 4.7; 95% CI, 1.9-11.6). Diet and lifestyle modifications based on traditional medicine can contribute greatly to the infertility treatment. Thus, many infertility cases can be treated without the need to use advanced methods. In case of using assisted reproductive techniques, traditional medicine can enhance the efficiency of these methods

Energy expenditure related biomarkers following bariatric surgery: a prospective six-month cohort study

Abstract Background Mitochondria dysfunction is one of the major causes of insulin resistance, and other countless complications of obesity. PGC-1α, and UCP-2 play key roles in energy expenditure regulation in the mitochondrial thermogenesis. However, the effects of bariatric surgery on the level of PGC-1α and UCP-2 and their relationships are unclear. Objective This study aimed to investigate the effect of bariatric surgery on key pathways in energy, and to assess the potential predictive role of body composition and metabolic parameters in this regard. Settings Hazrat-e Rasool General Hospital, Center of Excellence of International Federation for Surgery of Obesity. Methods This prospective cohort study was carried out on 45 patients with morbid obesity who underwent Roux-en-Y gastric bypass surgery. The patients have evaluated three-time points at baseline, three, and six months after the surgery. Body composition components, the levels of PGC-1α, UCP-2, and metabolic parameters were measured three times during this study. Results Significant changes in TWL%, EBMIL%, and metabolic lab tests were observed at three- and six months post-surgery (P < 0.001). The PGC-1α and UCP-2 had a significant increase three and then six-month post-operation compared with the baseline (P < 0.001). Moreover, multivariate linear regression analysis identified that the changing trend of PGC-1α was associated with insulin, uric Acid, HOMA-IR, fat mass and trunk fat mass. UCP-2 was associated with TSH, AST, fat mass and FFM. Conclusions Bariatric surgery has been shown to have a positive effect on UCP-2 and PGC-1α levels, as well as body composition and metabolic parameters. As a result, it is believed that bariatric surgery could improve thermogenesis and energy expenditure by enhancing mitochondrial biogenesis and function. However, further studies are needed to fully understand the precise mechanisms and possible causal relationship

کمبود اخلاط، حلقه‌ای مفقوده در تشخیص افتراقی بیماری‌ها

The human body is made of four humors and moderation in the quality and quantity of them can lead to health. If value of one or all humors is high can cause humors dominance and specific diseases related to humor and if some humor less than the amount required may cause diseases and even death. Deficiency of a humor can cause false signs and symptoms of increase the opposite humor so Deficiency of a humor is one of the most important differential diagnosis of humor dominance and if this disorder is not detected and to be treated as a conquering humor not only Improvement does not follow, but may also have undesirable side effects. This subject In Iranian traditional medicine has not been discussed in separate chapters and practitioners have referred to as distributed. This article reviewed the most important books on traditional medicine and expressed practitioner‘s belief about this subject.بدن انسان از اخلاط اربعه به وجود آمده است و صحت بدن با اعتدال اخلاط در کیفیت و کمیت محقق می‌شود. اگر یک یا همه اخلاط در کمیت زیاد باشند موجب امتلا و بیماری‌های خاص خلط مربوط می‌گردند و چنانچه بعضی از اخلاط از آنچه که مورد نیاز است کمتر باشند موجب بیماری و چه بسا مرگ می‌شوند. کمبود یک خلط می‌تواند به‌صورت کاذب موجب بروز علایم افزایش خلط مقابل گردد و در صورتی که این اختلال تشخیص داده نشده و به‌عنوان غلبه خلط تحت درمان قرار گیرد نه تنها بهبودی حاصل نمی‌گردد بلکه ممکن است عوارض نامطلوبی را نیز به‌دنبال داشته باشد. در کتاب‌های طب سنتی ایران کمبود اخلاط در فصل مستقلی مورد بحث واقع نشده است و حکما به صورت پراکنده به این مطلب اشاره کرده‌اند. به همین سبب با جستجو در متون اصلی طب سنتی دیدگاه حکما بررسی و تبیین گردید

عوامل و داروهای مؤثر بر اشتها و ارتباط آن با اخلاط از دیدگاه طب سنتی ایران

Appetite disorder and energy imbalance cause weight change and several complications such as obesity or malnutrition. Despite extensive researches on appetite and modifier factors, treatments of appetite disorders are still associated with many problems. This study aims at determining and investigating the relationship between four humors (Akhlat Arbaee) and appetite, causes and drugs affecting appetite referring to the books written by Avicenna, Razes and other Iranian Traditional Medicine Authoritative. This study showed that each natural humors has a specific effect on appetite and any change in the quantity and quality of humors can changes appetite. In addition, every variation in the temperament of organs, such as brain, heart and particularly stomach and liver has a great impact on the change of appetite and by repairing it we can control appetite disorders. There are also many other underlying diseases which can cause changes in appetite. Examining different drugs revealed that many simple substances which exist in drugs (advie mofrade) have a kind of effect on the appetite and can be used in order to control the appetite. According to Iranian traditional medicine viewpoints regarding the issue of appetite and the drugs prescribed to control it, by researching and studying in this field of study, approaches might be revealed to treat appetite disorders.اختلال اشتها و عدم تعادل انرژی سبب تغییر وزن و عوارض متعددی مانند چاقی یا سوء تغذیه می‌گردد. علي‌رغم تحقیقات گسترده در مورد اشتها و عوامل تغییردهنده آن هنوز هم در بسیاری از موارد، درمان اختلالات اشتها با مشکلات زیادی همراه است. در این مقاله براساس کتاب «قانون بوعلی سینا»، «الحاوی رازی» و سایر کتاب‌های معتبر طب سنتی ایران اشتها و اختلالات آن، رابطه اشتها با اخلاط اربعه و عوامل و داروهای مؤثر بر اشتها بررسی و تبیین شده است. این مطالعه نشان داد که هر یک از اخلاط طبیعی تأثیر خاصی بر اشتها دارند و هر تغییری در کمیت و کیفیت اخلاط می‌تواند موجب تغییر در اشتها گردد. علاوه بر این، تغییر مزاج اعضایی مثل مغز، قلب و به ویژه معده و کبد نقش عمده‌ای در تغییر اشتها دارد که با اصلاح مزاج آن­ها می‌توان به میزان زیادی اختلالات اشتها را کنترل کرد. بیماری‌های زمینه‌ای زیادی نیز می‌توانند موجب تغییر اشتها گردند. در بررسی داروها مشخص شد که مفردات فراوانی بر اشتها اثر دارند و می‌توانند در کنترل آن به‌کار گرفته شوند. با توجه به دیدگاه طب سنتی ایران در مورد اشتها و داروهای مؤثر بر آن، پس از مطالعه و واکاوی بیشتر شاید بتوان راه‌کار جدیدی در درمان اختلالات اشتها ارائه داد