Contextuality and Information Systems: how the interplay between paradigms can help

Through this paper, we theorize on the meanings and roles of context in the study of information systems. The literatures of information systems and information science both explicitly conceptualize information systems (and there are multiple overlapping definitions). These literatures also grapple with the situated and generalizable natures of an information system. Given these shared interests and common concerns, this paper is used as a vehicle to explore the roles of context and suggests how multi-paradigmatic research ??? another shared feature of both information science and information systems scholarship ??? provides a means to carry forward more fruitful studies of information systems. We discuss the processes of reconstructed logic and logic-in-use in terms of studying information systems. We argue that what goes on in the practice of researchers, or the logic-in-practice, is typified by what we are calling the contextuality problem. In response, we envision a reconstructed logic, which is an idealization of academic practices regarding context. The logic-in-use of the field is then further explained based on two different views on context. The paper concludes by proposing a model for improving the logic-in-use for the study of information systems

Social Networking Technologies and Informal Knowledge Sharing in Organizations

This presentation investigates the role of corporate social networking technologies in knowledge sharing. Through this research we will investigate the take-up and uses of social networktechnologies (SNTs) by knowledge workers in formal social organizations. Our premise is thatthe uses of SNTs, and the personal networks of informal ties that this use both enables andencourages, are mutually constitutive. We focus on the mutual constitution of social networksand SNTs because organizations are increasingly finding information sharing initiativesimperative to their knowledge management activities, and social networking is the most well understoodmeans to do this. In doing this research we pursue three contributions: (1) Conceptual insight and empiricalsupport for the material nature and value of digitally-enabled social connections. (2) Advancecurrent conceptual understanding of SNT’s organizational value. And, in doing this we buildfrom and synthesize current and relevant research from several intellectual communities such associal computing, information systems, social network analysis, and organizational studies. (3)Articulate organizationally-relevant design and governance principles regarding SNT uses

Digital assemblages, information infrastructures, and mobile knowledge work

We theorize mobile knowledge workers’ uses of digital and material resources in support of their working practices. We do so to advance current conceptualizations of both “information infrastructures” and “digital assemblages” as elements of contemporary knowledge work. We focus on mobile knowledge workers as they are (increasingly) self-employed (e.g., as freelancers, entrepreneurs, temporary workers, and contractors), competing for work, and collaborating with others: one likely future of work that we can study empirically. To pursue their work, mobile knowledge workers draw together collections of commodity digital technologies or digital assemblages (e.g., laptops, phones, public WiFi, cloud storage, and apps), relying on a reservoir of knowledge about new and emergent means to navigate this professional terrain. We find that digital assemblages are created and repurposed by workers in their infrastructuring practices and in response to mobility demands and technological environments. In their constitution, they are generative to both collaborative and organizational goals. Building from this, we theorize that digital assemblages, as individuated forms of information infrastructure, sustain stability and internal cohesion even as they allow for openness and generativity

Agency, Sociomateriality and Configuration Work

Social informatics research offers insights into the relationship between information technologies and social contexts. However, the material roles of information technologies, and their interplay with the agentic work of social actors, have not been addressed. Drawing on a field study of 37 mobile knowledge workers, we examine the dual material roles (enabling and constraining) played by information technologies in their work practices. We also investigate how these workers exert agency by fashioning multiple information technologies into a functioning digital assemblage. Although information technologies provide consequential affordances that enable mobilization of work across spaces and times, they simultaneously present design-driven, local, organizational, and temporal technological constraints that require mobile knowledge workers to engage in “configuration work” to make information technologies function effectively. Building on a sociomaterial perspective, we further discuss the interplay of information technologies and work practices enacted by mobile knowledge workers, in which both human and technological agency are materialized

Understanding Quantified-Selfers' Interplay between Intrinsic and Extrinsic Motivation in the Use of Activity-Tracking Devices

Interest in consumer tracking devices that measure movement to help consumers track and understand their daily activities has rapidly increased in recent years. Although a few studies have focused on the use of fitness tracking devices, we know little about how users’ existing motivation is complemented by motivation externally created from the device or how interplay between this external motivation and preexisting internal motivation of users affects use of the device over an extended period of time. We conducted semi-structured interviews with 15 Fitbit users in an academic institution to understand the multidimensional nature of motivation that shapes the long-term use of technology and its effects, and we found that Quantified-Selfers may have distinct motivation to use tracking devices. In the next step, we plan to conduct a comprehensive analysis of the Quantified Self online forum in order to explore Quantified-Selfers’ intrinsic and extrinsic motivations for using the device and tracking their activity data.ye

Personal Artifact Ecologies in the Context of Mobile Knowledge Workers

Recent work suggests that technological devices and their use cannot be understood in isolation, and must be viewed as part of an artifact ecology. With the proliferation of information and communication technologies (ICTs), studying artifact ecologies is essential in order to design new technologies with effective affordances. This paper extends the discourse on artifact ecologies by examining how such ecologies are constructed in the context of mobile knowledge work, as sociotechnical arrangements that consist of technological, contextual, and interpretive layers. Findings highlight the diversity of ICTs that are adopted to support mobile work practices, and effects of individual preferences and contextual factors (norms of collaboration, spatial mobility, and organizational constraints)

Mobility of Knowledge Work and Affordances of Digital Technologies

Information communication technologies (ICTs) enable mobile knowledge workers to conduct information practices.These practices ensure access, keep social cohesion, maintain acuity, uphold work rhythm, and enact work-life balance.Mobile knowledge workers mobilize their work practices across space, time, social situations, and contexts.Mobile knowledge workers employ personalized assemblages of ICTs to best achieve mobilization across different boundaries. The focus of this work arises from two needs within information science literature: (1) to understand more, from an empirically driven perspective, about the increasingly visible yet understudied mobile work population, and (2) to address more clearly, from a theoretical standpoint, the ways in which information and communication technologies (ICTs) mediate the work practices of these mobile workers. Drawing on the affordance perspective, this research goes beyond simplistic conceptualizations of technological effects to explore the roles of multiple ICTs in enabling mobile knowledge work. In this paper, the use of ICTs in mobilizing information practices and the ways in which ICTs generate affordances along different mobility dimensions (spatial, temporal, contextual, and social) are examined. The empirical base of this research is a field of study of 33 mobile knowledge workers (MKWs); broadly, it focuses on the ways they employ ICTs to accomplish work in dynamic and unpredictable work conditions

The Association of Fat-Mass-and Obesity-Associated Gene Polymorphism (rs9939609) With Colorectal Cancer: A Case-Control Study

Background and Aim: The association between the rs9939609 polymorphism of fat mass and obesity-associated gene (FTO) and risk of colorectal cancer is controversial. This study aims to evaluate the relationship between FTO rs9939609 polymorphism and colorectal cancer (CRC) in Iranian people. Methods: A case-control study was conducted on 125 patients with CRC and 250 healthy subjects in Tehran, Iran. Demographic data and blood samples were collected from all participants. Genotyping of rs9939609 polymorphism was performed by the tetra-primer amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) method. Results: The occurrence of AA genotype of FTO rs9939609 polymorphism in the colorectal cancer patients was significantly higher compared to that of healthy subjects (16.4 vs. 2.9%, respectively, P=0.02). The association between the frequency of risk allele of the FTO polymorphism and CRC (B=1.67, P=0.042) remained significant after adjustment for age. Further adjustment for gender (model 2) and marital status (model 3) did not change this result (B=1.67, P= 0.042 and B=1.67, P=0.043, respectively). The results remained significant after additional adjustment for ethnicity (B=1.57, P= 0.047). Conclusion: We found a positive association between the A allele of the rs9939609 polymorphism and CRC. Future studies are required to identify the underlying mechanisms

Signal transduction pathway mutations in gastrointestinal (GI) cancers : a systematic review and meta-analysis

The present study was conducted to evaluate the prevalence of the signaling pathways mutation rate in the Gastrointestinal (GI) tract cancers in a systematic review and meta-analysis study. The study was performed based on the PRISMA criteria. Random models by confidence interval (CI: 95%) were used to calculate the pooled estimate of prevalence via Metaprop command. The pooled prevalence indices of signal transduction pathway mutations in gastric cancer, liver cancer, colorectal cancer, and pancreatic cancer were 5% (95% CI: 3–8%), 12% (95% CI: 8–18%), 17% (95% CI: 14–20%), and 20% (95% CI: 5–41%), respectively. Also, the mutation rates for Wnt pathway and MAPK pathway were calculated to be 23% (95% CI, 14–33%) and 20% (95% CI, 17–24%), respectively. Moreover, the most popular genes were APC (in Wnt pathway), KRAS (in MAPK pathway) and PIK3CA (in PI3K pathway) in the colorectal cancer, pancreatic cancer, and gastric cancer while they were beta-catenin and CTNNB1 in liver cancer. The most altered pathway was Wnt pathway followed by the MAPK pathway. In addition, pancreatic cancer was found to be higher under the pressure of mutation compared with others based on pooled prevalence analysis. Finally, APC mutations in colorectal cancer, KRAS in gastric cancer, and pancreatic cancer were mostly associated gene alterations

The association between fat mass and obesity‐associated ( FTO ) genotype and serum vitamin D level in breast cancer patients

Abstract: The preventive effect of vitamin D against breast cancer can be influenced by gene polymorphisms. This study aimed to investigate the association between serum level of 25(OH) vitamin D and FTO genotype in breast cancer patients. A cross‐sectional study was carried out on 180 newly diagnosed patients with breast cancer in Tehran, Iran. The blood samples were collected from the participants in order to assess the FTO gene rs9939609 polymorphism by the tetra‐primer amplification refractory mutation system (Tetra‐ARMS) PCR method. The serum level of 25(OH) vitamin D was measured using the direct competitive enzyme‐linked immunosorbent assay (ELISA) method. The association between vitamin D and the FTO genotype in patients with breast cancer was assessed after adjustment for cofounders. The frequency of TT, AT and AA genotypes in the breast cancer patients were 43% (n = 77), 49% (n = 89) and 8% (n = 14), respectively. All patients with higher than 40 ng/dl of serum 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele (p = 0.019). No linear association was found between the number of FTO risk allele and the level of serum vitamin D. All patients with high serum level of 25(OH) vitamin D had one or two copies of FTO rs9939609 risk allele. FTO gene polymorphisms may counteract the beneficial effects of vitamin D in breast cancer prevention. Further studies can help to better understand the genetic factors predisposing to breast cancer and their effect on the association between vitamin D and breast cancer