Adding highly generic subsets of ω2\omega_2

Starting from the $\rm{GCH},$ we build a cardinal and $\rm{GCH}$ preserving generic extension of the universe, in which there exists a set $A \subseteq \omega_2$ of size $\aleph_2$ so that every countably infinite subset of $A$ or $\omega_2 \setminus A$ is Cohen generic over the ground model

Renal biochemical and histopathological alterations of diabetic rats under treatment with hydro alcoholic Morus nigra extrac.

Introduction: Morus nigra fruit is known to have antioxidant effects and used to control the blood sugar level in traditional medicine. Objectives: This study was conducted to investigate the biochemical and histopathological changes in the serum and kidneys of diabetic rats treated with hydroalcoholic M. nigra extract. Materials and Methods: In this study, 60 male Wistar rats were divided into five groups of 12 each. After induction of diabetes with alloxan, the diabetic rats were treated with hydroalcoholic extract of M. nigra at different concentrations. Then, the animals were anesthetized and the serum levels of glucose, creatinine, and urea as well as kidney tissue catalase level measured. The kidney tissue was also histopathologically examined. Results: Milder glomerular damage was seen in the group treated with 800 mg/kg of the M. nigra extract compared with diabetic and positive controls, and no difference in the expansion of mesenchymal tissue into renal glomerular vessels observed between the group treated with 800 mg/kg of M. nigra extract and diabetic and positive controls. Furthermore, creatinine levels were significantly higher and urea levels significantly lower in the group treated with 800 mg/kg of M. nigra extract than healthy and positive control groups (P<0.05). Conclusion: Administration of M. nigra extract at 800 mg/kg can prevent kidney tissue damage in diabetic rats and this fruit seems to be beneficial to patients with diabetes

Cytotoxicity effect of pineapple extract on breast cancer cells (4T1)

Aqueous extract of pineapple (Bromelain) is used in medicine. Bromelain has anticancer effect on leukemia, lymphoma, sarcoma and melanoma. The purpose of this study was to evaluate the anticancer effect of bromelain on mouse breast cancer (4T1) cells under in-vitro conditions. Methods: Mouse breast cancer (4T1) cells were incubated with different concentrations of the bromelain for 2, 24, 48 and 72 hours. The growth-inhibitory was investigated via 3 (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium-bromide (MTT) assay. Kruskal-Wallis and Dunn’s tests were used to evaluate the statistical significance of the difference between the experimental and control groups. Findings: Bromelain significantly inhibited proliferation of 4T1 cells in a concentration-dependent manner. In all concentrations, cell viability decreased with respect to the control incubated cells in the absence of extract (P < 0.05). Bromelain exerted highest antiproliferative effects on 4T1 cells for concentrations of 100, 200, 300, 400 and 600 µg/ml (P < 0.05) for 24, 48 and 72 hours, while cell viability increased for times shorter than 2 hours. The half maximal inhibitory concentration (IC50) value of 142.6 g/ml was obtained from treating 4T1 cells. Conclusion: Results showed that bromelain has cytotoxic effects on the growth and proliferation of 4T1 cells for 24, 48 and 72 hours of incubation. This study is ongoing to assess the extract mechanism of action

Dilated Cardiomyopathy Several Months after Hemolytic Uremic Syndrome

This is a report of a 44-month-old baby girl diagnosed as a case of atypical hemolytic uremic syndrome (aHUS) presenting with hematuria, periorbital edema, anemia, thrombocytopenia, and hypertension lacking any history of previous bloody diarrhea. She was treated with plasma infusion followed by plasmapheresis and peritoneal dialysis. After two months, she was discharged in remission undergoing periodic plasmapheresis. Four months later, she was visited for fatigue, tachypnea, and palpitation. Cardiac evaluation revealed dilated cardiomyopathy with an ejection fraction of 15-20%.  She was hospitalized and treated with inotropes and diuretics; one week later, she was discharged in a favorable condition. After six months follow-up, she showed an acceptable renal and cardiac state. It seems that cardiomyopathy can occur as a late and rare complication of HUS. We recommend cardiac evaluation for all patients with HUS at its presentation and in later follow-ups.  Keywords: Cardiomyopathy; Hemolytic Uremic Syndrome; Child

The Effect of Raising Electricity Price on Welfare of the Household Sector in RuralAreas of Guilan Province,Iran

Present study investigates the effect of soaring residential electricity price on the welfare of rural individuals in Guilan Province by Almost Ideal Demand System (AIDS) in which the elasticity’s and welfare variations were calculated by Compensation Variations (CV) and Equivalent Variations (EV) for the time period of 1991-2012. It was shown that the absolute value of income and price elasticity of electricity was less than one unit. Low price elasticity of the demand shows the slight impact of price variations on the demand for electricity in the studied period, on the one hand, and the lack of an appropriate substitute for electricity in residential sector, on the other hand. The calculation of welfare variations and its comparison with the share of electricity in the paid subsidy shows that with 50% and 100% increase in residential electricity price, the cash paid to the households is less that the amount acquired. Accordingly, it can be argued that the direct effect of residential electricity price modification (increase) has not been compensated. In fact, the welfare loss of the households, due to more expensive electricity, is more than the acquired welfare. Yet, in a gradual increase scenario, the calculated CV is less than the payments to the families, and hence it is the only price policy that does not impose a loss on families and improves their welfare

Methodological Analysis in Iranian Sociological Research

This research, evaluating social knowledge identity in terms of methodology in Iran, showed that the knowledge suffers from dislocation and complexity. From one hand, the knowledge followed by the social scholars has fallen far from its production, reproduction and fixation roots in developed countries, and the scholars do not observe the processes of the knowledge formation and just regard the consequences or results of the social knowledge. On the other hand, the knowledge is not concerned with conducting social setting and infrastructure in Iran; because this effort needs elites’ support and public interest at the same time and the condition has not fulfilled yet. Data of the research were gathered relied on logical bases of qualitative research, interpretive approach and abductive strategy, and by conducting directed qualitative content analysis through multiple purposive sampling, and rhetorical reading of the performed interviews and also of the 55 works conducted by six participants of the research

Effect of phenobarbital on nitric oxide level in term newborn infants with perinatal asphyxia

Perinatal asphyxia (PA) is very significant in perinatal medicine due to the involvement of the central nervous system. This study was conducted to investigate the biochemical, clinical, and paraclinical changes associated with phenobarbital administration in neonates with PA. Methods: In this prospective, case-control study, 30 neonates with PA in two groups of 15 each (case and control) were investigated. The case group received 20 mg/kg intravenous phenobarbital within six hours of birth, and the control group did not receive phenobarbital. Serum concentrations of nitric oxide (NO) were measured at enrollment and one week after birth in the two groups. Clinical, electroencephalography, and magnetic resonance imaging findings of the two groups were compared. Results: At enrollment, the two groups did not differ in clinical severity, seizure incidence, or NO concentration. After one week, NO concentration was significantly lower in the case group (p < 0.050), but there was no significant difference in other variables between the two groups. Conclusions: Early administration of phenobarbital in term neonates with PA could protect them against encephalopathy