The epidemiology of dietary supplements consumption in the athletes of Karaj Iran

Background and aims: Nutrition has a determinant role in success of professional athletes and dietary supplements can play an important role for supplying the nutritional needs for them in some situations. Consumption of Dietary Supplements (DS) was significantly increased in recent years. Based on this fact, assessing the amount, purposes and type of the supplements are all as prior as the affective factors on the choice and preparation of that. Therefore, we are going to evaluate the consumption of dietary supplement among athletes of Karaj, a big city near Tehran, capital of Iran. Methods: In this cross-sectional study, we enrolled 195 athletes that were randomly selected from 8 sport clubs of Karaj city between December 2014 and February 2015. A self-administered questionnaire containing 17 questions was used to evaluate the field of sport, history and reasons of consuming the supplements, source of information and providing centers. Validity and reliability of questionnaire determined through panel of experts and Cronbach’s alpha (N=25, α=0.85) respectively. Results: The mean age of the athletes was 24±7 years old. Thirty six percent of participants consumed the supplement during the study and 49 reported the previous use of it. The most important reasons of supplement’s consumption were empowering sport’s ability by 48. Also supplying needs of body by 39 and increasing muscle’s mass by 31 named the second and third reason of supplement use. For 64 of participants coach is the most important source of information and question about DS, and then nutritionists (24) and Internet (23) were after that in order. Sixty one percent of participants considered the coach as the most important source for buying supplements and then 51 of participants mentioned pharmacies as second main source for buying DS. Protein supplements, vitamins, creatine and glutamine were named as the most commonly used DS. Discussions: The results of this study indicate that dietary supplements usage is common among athletes. According to these results, coaches have a significant role in athlete information and supplying the required supplements of athletes. It is necessary to consider the appropriate policy to remove coaches from the supply chain of dietary supplements

Tacrolimus toxicity in organ transplantation: an overview

Tacrolimus is a macrolide lactone antibiotic, and acts as a calcineurin inhibitor. It is widely used to prevent organ transplant rejection. It has been approved as first-line treatment after organ transplantation. Tacrolimus has narrow therapeutic range and wide individual variability in its pharmacokinetics. In organ transplantation, immunosuppression is associated with important risks, in particular, related to infections and cardiovascular diseases, which are the predominant causes of death in those with a functioning graft. This review focuses on toxicity of tacrolimus after transplantation. Tacrolimus toxicity is a major determinant of morbidity and mortality in organ recipients after transplantation. Therefore, reducing toxicities has become a priority. To decrease the incidence of side effects, and expand graft survival, the appropriate initial and maintenance dose of tacrolimus is essential. Clinical conditions that influence tacrolimus pharmacokinetics, such as hemorrhage, systemic inflammation and shock, all result in higher variations of tacrolimus concentrations. In addition, unbound plasma concentration is a major important reasonable parameter for monitoring of receiving optimal tacrolimus dosing in the unstable patient. Therefore, the approach of tacrolimus monitoring is vital and will support to avoid tacrolimus toxicity in the early days after transplantation

Individuals\u27 Absorptive Capacity in Enterprise System Assimilation

The capability of an individual to absorb knowledge about enterprise resource planning (ERP) is a critical element in the development of an organisation’s absorptive capacity (ACAP) during assimilation phase of ERP. Prior research have tended to overlook the roles that individuals play in identify external and internal knowledge, assimilate and exploit ERP knowledge. By defining ACAP at the individual level, we seek to enrich our understanding of how individual learn ERP knowledge and how such efforts facilitate the ERP assimilation within organisations. We develop a theoretical model to investigate the assimilation of enterprise systems in the post-implementation stage. Specifically, this model explains how communication climate and top management participation moderates the impact of Individuals’ ACAP on the assimilation of ERP systems

Remifentanil versus Fentanyl/Midazolam in Painless Reduction of Anterior Shoulder Dislocation; a Randomized Clinical Trial

Introduction: Performance of painful diagnostic and therapeutic procedures is common in emergency department(ED), and procedural sedation and analgesia (PSA) is a fundamental skill for every emergency physician.This studywas aim to compare the efficacy of remifentanil with fentanyl/midazolam in painless reduction of anteriorshoulder dislocation. Methods: In this randomized, double blind, clinical trial the procedural characteristics,patients satisfaction as well as adverse events were compared between fentanyl/midazolamand remifentanilfor PSA of 18–64 years old patients, which were presented to ED following anterior shoulder dislocation.Results: 96 cases were randomly allocated to two groups (86.5% male). There were no significant difference betweengroups regarding baseline characteristics. Remifentanil group had lower duration of procedure (2.5§1.6versus 4.6§1.8 minutes, p Ç 0.001), higher pain reduction (53.7§13.3 versus 33.5§19.6, p Ç 0.001), lower failurerate (1 (2.1%) versus 15 (31.3%), p Ç 0.001), higher satisfaction (p Æ 0.005). Adverse events were seen in 12 (25%)patients in midazolam/fentanyl and 8 (16.7%) cases in remifentanil group (p Æ 0.122). Conclusion: It seemsthat use of remifentanil resulted in lower procedural time, lower failure rate, and lower pain during procedureas well as higher patient satisfaction in comparison with midazolam/fentanyl combination in anterior shoulderdislocation