Supply Chain Management and Organizational Performance: The Moderating Effect of Supply Chain Complexity

This study investigates the relationship between various factors in supply chain management (customer relationship, level of information, sharing postponement, sharing quality of information, and strategic supplier partnership) and their impact on organizational performance. This research relies on primary data collected through the use of questionnaires. The research will concentrate on Jordans tourist industry. Only 261 were approved and examined using SmartPLS.The results of the study indicate that sharing postponement, sharing quality of information, and strategic supplier partnership have a strong positive impact on organizational performance. However, the relationship between customer relationship and organizational performance is not statistically significant. The relationship between level of information and organizational performance is statistically significant. These findings suggest that organizations can improve their performance by implementing strategies to manage and optimize these factors in their supply chain. This study also evidenced that Supply Chain Complexity as moderator helps increase organiizational performance by interacting with Strategic Supplier Partnership, Level of Information, Sharing Quality of Information, Sharing Postponement. However, it should be noted that there is some inconsistency in the results compared to previous studies, and the relationship between these factors and organizational performance is still not fully understood. This highlights the need for further research in this area to gain a better understanding of how these factors impact organizational performance

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Green Energy Products and The Relationship of The Customer's Consideration for The Environment and Perceived Risk Involved with The Mediating Position of Customer Purchasing Intentions

The goal of this study is to examine green energy goods and the relationship of the consumer concern for the atmosphere and perceived danger associated with the mediating role of the customer buying intentions; the point of view of international tourists in Jordan. The sampling technique was accompanied by a cross-sectional, quantitative, and explanatory design, whereby 340 individuals were chosen using a random population method reflecting the tourists of the Jordan for a two-week span beginning on 11/11/2020. By circulation of a paper questionnaire and with the aid of some tourist guides, the person sample was achieved. Moreover, through two stages, the structural model was being analyzed. In the first stage (direct effect) the effect (PK-appropriate CPI) was not important, so H1 was not sponsored. However, the result was important with regard to (PK ΔPR), and hypothesis 2a was supported. (PK ΔEC) were not significant, so hypothesis 2a was not supported. Furthermore, the direct impact of product danger and environmental problems on purchasing intentions were explored, resulting in negative/positive and important findings (PR over CPI, P 0.05), so H3awere was endorsed, however, H3b was not supported

INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex

International audienceAbstract Oral-facial-digital (OFD) syndromes are a heterogeneous group of congenital disorders characterized by malformations of the face and oral cavity, and digit anomalies. Mutations within 12 cilia-related genes have been identified that cause several types of OFD, suggesting that OFDs constitute a subgroup of developmental ciliopathies. Through homozygosity mapping and exome sequencing of two families with variable OFD type 2, we identified distinct germline variants in INTS13 , a subunit of the Integrator complex. This multiprotein complex associates with RNA Polymerase II and cleaves nascent RNA to modulate gene expression. We determined that INTS13 utilizes its C-terminus to bind the Integrator cleavage module, which is disrupted by the identified germline variants p.S652L and p.K668Nfs*9. Depletion of INTS13 disrupts ciliogenesis in human cultured cells and causes dysregulation of a broad collection of ciliary genes. Accordingly, its knockdown in Xenopus embryos leads to motile cilia anomalies. Altogether, we show that mutations in INTS13 cause an autosomal recessive ciliopathy, which reveals key interactions between components of the Integrator complex