Bronchial Asthma and Salivary Surfactant Protein D: Review Article

Background: Chronic bronchial inflammation underlies asthma, which is a complex disease with varied and largely reversible blockage of the respiratory route. Asthma is a major public health issue that affects people of all ages around the world. Many countries are seeing an increase in the prevalence of this disease, particularly among children. Among children, asthma is the most frequent long-term condition, accounting for more than half of all missed school days, emergency room consultations, and hospitalizations. Surfactant Protein D, a pattern-recognition molecule, dampens elevated levels of particular antibodies, alveolar macrophage accumulation, eosinophilia, and subepithelial fibrosis and mucous metaplasia, as well as airway hyper-reactivity in allergic asthma in vivo. Objective: In order to discover the connection between children's bronchial asthma and surfactant protein D. Conclusion: Salivary SP-D is a simple, low-cost, quick, and noninvasive way to collect saliva from children. Salivary SP-D levels may be linked to asthma exacerbation severity and peripheral airway resistance

Targeted Delivery Of Nrf2 Sirna Using Modular Polymeric Micellar Nanodelivery System For Efficient Target Gene Knockdown In Hepatocellular Carcinoma

Tumor selective drug delivery as well as chemotherapy associated multi drug resistance (MDR) pose tremendous hurdles for effective cancer therapy. In this regard, designing multifunctional nanocarriers loaded with drug/gene payloads and engineered with tumor targeting ligands can serve as a modular platform for targeted drug/gene delivery. In this study we undertook the synthesis of a self-assembling block copolymer constructed using poly(styrene-co-maleic anhydride, partial iso-octyl ester) (SMAPIE) and branched polyethylenimine (PEI) as building blocks and evaluated its micelle forming ability, siRNA complexation and siRNA delivery potentials. In addition, we engineered galactosamine decorated nanomicelles using modular “click” chemistry based approaches for evaluating the targeted delivery of Nrf2 siRNA to Hep G2 liver cancer cells overexpressing asialoglycoprotein receptors (ASGPRs). Our results demonstrate that the galactosamine decorated nanocarriers could effectively deliver Nrf2 siRNA into Hep G2 liver cancer cells resulting in efficient target gene knockdown, evincing its potential for targeted liver cancer therapy

Mitigating Crack Propagation in a Highly Maneuverable Flight Vehicle Using Life Extending Control Logic

In this research, life extending control logic is proposed to reduce the cost of treating the aging problem of military aircraft structures and to avoid catastrophic failures and fatal accidents due to undetected cracks in the airframe components. The life extending control logic is based on load tailoring to facilitate a desired stress sequence that prolongs the structural life of the cracked airframe components by exploiting certain nonlinear crack retardation phenomena. The load is tailored to include infrequent injections of a single-cycle overload or a single-cycle overload and underload. These irregular loadings have an anti-intuitive but beneficial effect, which has been experimentally validated, on the extension of the operational structural life of the aircraft. A rigid six-degree-of freedom dynamic model of a highly maneuverable air vehicle coupled with an elastic dynamic wing model is used to generate the stress history at the lower skin of the wing. A three-dimensional equivalent plate finite element model is used to calculate the stress in the cracked skin. The plate is chosen to be of uniform chord-wise and span-wise thickness where the mechanical properties are assigned using an ad-hoc approach to mimic the full scale wing model. An in-extensional 3-node triangular element is used as the gridding finite element while the aerodynamic load is calculated using the vortex-lattice method where each lattice is laid upon two triangular finite elements with common hypotenuse. The aerodynamic loads, along with the base-excitation which is due to the motion of the rigid aircraft model, are the driving forces acting on the wing finite element model. An aerodynamic control surface is modulated based on the proposed life extending control logic within an existing flight control system without requiring major modification. One of the main goals of life extending control logic is to enhance the aircraft\u27s service life, without incurring significant loss of vehicle dynamic performance. The value of the control-surface deflection angle is modulated so that the created overstress is sufficiently below the yield stress of the panel material. The results show that extension in crack length was reduced by 40% to 75% with an absence of damage mitigation logic. Moreover, the desired structural integrity is satisfied without affecting the air vehicle dynamic performance

Effects of Age and Season on Serum Testosterone Level in Male Buffaloes

The aim of the present study was to detect the changes occurring in serum testosterone profile in male buffaloes. Thirty blood samples from apparently healthy slaughtered male buffaloes were taken and divided into three age groups, 1.5–1.8, 2 –2.5 and 3–4 years. Scrotal circumference and testicular measurements were conducted and the seminal glands were obtained immediately after slaughter. The fructose content was determined in tissue of seminal gland using spectrophotometer. Our investigations were extended to determine the effect of the seasons on serum testosterone levels (Indoor study). There were significant differences between scrotal circumference, testicular and seminal glands measurements with the age of the animals. There were no significant differences neither between average fructose content of seminal glands (mg/ gland) nor fructose concentration per 1 g. tissue with age, were detected. In addition, it is noticed that the serum testosterone level was higher in the first group (1. 5–1.8 years), then a decline in testosterone levels was recorded from 2.0–2.5 to 3–4 years of age with no significant difference between the different groups. A higher mean testosterone concentration (1.72 ng/ ml) was recorded in autumn, while the lowest average concentration (0.77 ng / ml) was recorded in winter. However, there was no significant difference in testosterone levels between different seasons of the year. Hence, we could suppose that the Egyptian water buffalo bull has no typical breeding season

Assessing Soft Skills for Software Requirements Engineering Processes

Software requirement engineering (SRE) is the process of establishing, documenting, and maintaining software requirements. The goal of this research is to investigate the importance of soft skills in SRE. The data collection was performed through an online questionnaire. Descriptive statistics, principal components analysis (PCA), and stepwise regression techniques were used to analyze the data. A comprehensive review determined the 31 soft skills associated with SRE. There were 122 software development experts in Gaza who participated in the survey. The PCA analysis extracted six factors, named problem-solving, learning willingness, commitment, pressure resilience, critical thinking, and interpersonal skills. The analysis discovered that the level of SRE practice in Gaza is 73.71%. Furthermore, it was determined that 89.2% of respondents have critical thinking skills, and 85% have problem-solving and commitment skills. The result shows that all soft skills factors have strong links to SRE. However, only four soft skills (problem-solving, willingness to learn, pressure tolerance, and critical thinking) were found to have an impact on SRE. Considering these findings, we recommend focusing on the development of soft skills, especially problem-solving and willingness to learn skills, for the team analyzing software system requirements

Effects of novel muscarinic M3 receptor ligand C1213 in pulmonary arterial hypertension models.

Pulmonary hypertension (PH) is a complex disease comprising a pathologic remodeling and thickening of the pulmonary vessels causing an after load on the right heart ventricle that can result in ventricular failure. Triggered by oxidative stress, episodes of hypoxia, and other undetermined causes, PH is associated with poor outcomes and a high rate of morbidity. In the neonate, this disease has a similar etiology but is further complicated by the transition to breathing after birth, which requires a reduction in vascular resistance. Persistent pulmonary hypertension of the newborn (PPHN) is one form of PH that is frequently unresponsive to current therapies including inhaled nitric oxide (due to lack of proper absorption and diffusion), and other therapeutics targeting signaling mediators in vascular endothelium and smooth muscle. The need for novel agents, which target distinct pathways in pulmonary hypertension, remains. Herein, we investigated the therapeutic effects of novel muscarinic receptor ligand C1213 in models of PH We demonstrated that via M3 muscarinic receptors, C1213 induced activating- eNOS phosphorylation (serine-1177), which is known to lead to nitric oxide (NO) production in endothelial cells. Using signaling pathway inhibitors, we discovered that AKT and calcium signaling contributed to eNOS phosphorylation induced by C1213. As expected for an eNOS-stimulating agent, in ex vivo and in vivo models, C1213 triggered pulmonary vasodilation and induced both pulmonary artery and systemic blood pressure reductions demonstrating its potential value in PH and PPHN In brief, this proof-of-concept study provides evidence that an M3 muscarinic receptor functionally selective ligand stimulates downstream pathways leading to antihypertensive effects using in vitro, ex vivo, and in vivo models of PH