24 research outputs found
Diagnosis and Pharmacotherapy of Stable Chronic Obstructive Pulmonary Disease : The Finnish Guidelines
Peer reviewe
Emphysema quantification using chest CT: influence of radiation dose reduction and reconstruction technique
Effect of procalcitonin-guided therapy on antibiotic usage in the management of patients with chronic obstructive pulmonary disease with acute exacerbation
Differences in routes of guiding catheters for left coronary artery according to access sites assessed by the combined angiography-computed tomography system
Emphysema quantification using low-dose computed tomography with deep learning–based kernel conversion comparison
CT Air Trapping Is Independently Associated with Lung Function Reduction over Time
<p>Purpose: We aimed to study the association between lung function decline and quantitative computed tomography (CT) air trapping.</p><p>Materials and Methods: Current and former heavy smokers in a lung cancer screening trial underwent volumetric low-dose CT in inspiration and expiration. Spirometry was obtained at baseline and after 3 years. The expiratory to inspiratory ratio of mean lung density (E/I-ratio(MLD)) was used to quantify air trapping. CT emphysema was defined as voxels in inspiratory CT below -950 Hounsfield Unit. Linear mixed modeling was used to determine the association between CT air trapping and lung function.</p><p>Results: We included 985 subjects with a mean age of 61.3 years. Independent of CT emphysema, CT air trapping was significantly associated with a reduction in forced expiratory volume in one second (FEV1) and the ratio of FEV1 over the forced vital capacity (FEV1/FVC); FEV1 declines with 33 mL per percent increase in CT air trapping, while FEV1/FVC declines 0.58% per percent increase (both p</p><p>Conclusion: In a lung cancer screening cohort, quantitatively assessed air trapping on low-dose CT is independently associated with reduced lung function and accelerated decline of FEV1/FVC.</p>