New Blended Learning Strategy Based on Flipped-Learning for Vocational Work-Linked Training

In a changing Moroccan educational landscape, Addressing teaching development needs is becoming a major issue in vocational work-linked Training. In this context, this paper present a new blended learning strategy based on the flipped classroom, using a social learning platform as support. Through this strategy, we increased the time dedicated to regulation by the implementation of a self-regulation and a co-regulation online in first time, and other regulation in classroom. The result showed that this strategy guides and increases the time of initial training, and improve the efficiency, performance of student teachers while supporting teaching needs and self-learning skills. Keywords: Blended learning, flipped learning, vocational work-linked Trainin

Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: Mechanistic implications

<p>Abstract</p> <p>Background</p> <p>Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. The functional enzyme is a homo-tetramer with four active sites located at dimeric interfaces.</p> <p>Results</p> <p>The catalytic mechanism was investigated through a ternary complex formed between the enzyme, uric acid, and cyanide that stabilizes an intermediate state of the reaction. When uric acid is replaced by a competitive inhibitor, no complex with cyanide is formed.</p> <p>Conclusion</p> <p>The X-ray structure of this compulsory ternary complex led to a number of mechanistic evidences that support a sequential mechanism in which the two reagents, dioxygen and a water molecule, process through a common site located 3.3 Å above the mean plane of the ligand. This site is built by the side chains of Asn 254, and Thr 57, two conserved residues belonging to two different subunits of the homo-tetramer. The absence of a ternary complex between the enzyme, a competitive inhibitor, and cyanide suggests that cyanide inhibits the hydroxylation step of the reaction, after the initial formation of a hydroperoxyde type intermediate.</p

Ultrafiltration of Moroccan Valencia orange juice: juice quality, optimization by custom designs and membrane fouling

The growing demand for healthy foods has forced researchers to develop processes capable of concentrating or clarifying fruit juices while producing high quality products and the most promising techniques are membrane techniques. However, the obstacle of these techniques is the fouling problem. The objective of this study is to clarify Moroccan Valencia orange juice by ultrafiltration (UF) using two plate membranes characterized by different membrane materials (polyether sulfone (PES) and polysulfone (PS) with a molecular weight cutoff (MWCO) of 30 and 20 k Da respectively. The performance of these membranes was studied in terms of selectivity and productivity in respect to parameters describing juice quality. In the first part of this work, the response surface method (RSM) based on custom designs (CD) was used to model and optimize the UF process. The independent variables of the RSM method are transmembrane pressure (TMP) and feed flow rate (FF), while permeate flux is considered as a response. Secondly, Hermia model and resistance model were applied to describe and to identify the fouling mechanism. According to the results, the two membranes kept the original composition while the total suspended solids (SS) and the pectin content were completely removed. Both factors (TMP) and (FF) influence significantly the permeate flux. A TMP of 1,99-2 bar and FF of 229,99-330 L/h for PES and PS respectively were obtained. ANOVA of the regression model showed that both models are highly significant with R2 &gt; 0,95. However, the PES membrane exhibits a permeate flux which is greater than the PS membrane. The rejection rates of the monitored parameters were lower than those obtained by the PS membrane. The concentration polarization is the main cause of the flux drop and it appears that, for both membranes, the fouling is due to surface fouling mechanisms which is a cake formation

Pleistocene and Holocene peopling of Jerada province, eastern Morocco: introducing a research project

The Aïn Beni Mathar – Guefaït (ABM-GFT) region in Eastern Morocco is the object of an archaeological, palaeontological, geological and geochronological research project, led by an international team since 2006. The research in this former fluvio-lacustrine basin, roughly 2000 km2, has revealed a significant number of Pleistocene and Holocene sites. Here we introduce the research project, that we conduct in the region, the main issues it aims to address, and the results already obtained

Le peuplement humain pendant le Pléistocène et l’Holocène dans la province de Jerada, Maroc oriental : introduction d’un projet de recherche

[EN] The Aïn Beni Mathar – Guefaït (ABM-GFT) region in Eastern Morocco is the object of an archaeological, palaeontological, geological and geochronological research project, led by an international team since 2006. The research in this former fluvio-lacustrine basin, roughly 2000 km2, has revealed a significant number of Pleistocene and Holocene sites. Here we introduce the research project, that we conduct in the region, the main issues it aims to address, and the results already obtained.[FR] Depuis 2006, la région de Aïn Beni Mathar – Guefaït (ABM-GFT) au Maroc Oriental, fait l’objet d’un projet de recherche en archéologie, paléontologie, géologie et géochronologie, mené par une équipe internationale. Ces recherches ont permis la découverte d’un nombre significatif de gisements d’âge Pléistocène et Holocène, dans un ancien bassin fluvio-lacustre, qui s’étend sur une surface de 2000 km2. Notre objectif ici est de présenter le projet de recherche, que nous entamons dans la région, la problématique qu’il traite et les premiers résultats déjà obtenus.Funding for this research was provided by: Palarq Foundation, Spanish Ministry of Culture and Sport (Ref: 42-T002018N0000042853 & 170-T002019N0000038589), Direction of Cultural Heritage (Ministry of Culture and Communication, Morocco), Faculty of Sciences (Mohamed 1r University of Oujda, Morocco), INSAP (Institut National des Sciences de l’Archéologie et du Patrimoine), Spanish Ministry of Science, Innovation and Universities (Ref: CGL2016-80975-P, CGL2016-80000-P, PGC2018-095489-B-I00 and PGC2018-093925-B-C31) and Research Groups Support of the Catalonia Government (2017 SGR 836 and 2017 SGR 859). R.S-R, M.G.CH., J.I.M., A.C., F.R., A.R.-H., E.A., I.E., F.B., J.A., HA.B., P.S., P.P., D.L., I.R. y E.M. research is funded by CERCA Programme/ Generalitat de Catalunya. J.I.M. and A.R.-H research is funded by the Spanish Minitry of Science and Innovation under the “María de Maeztu” Program for Unities of Excellence (CEX2019-000945-M). M.S. has been granted by the Research Program UAM Tomás y Valiente 2019. C.T. is funded by the Ramón y Cajal Program. M.F. and M.E.A. received a fellowship under the Erasmus Mundus Scholarship of the European Education and Culture Executive Agency in the Master in Quaternary and Prehistory at URV. The research of M.D. is funded by the Australian Research Council (ARC) Future Fellowship Grant FT150100215 and the Ramón y Cajal Program (RYC2018-025221-I). P.P. has been granted a post-doctoral post under the Spanish Ministry of Science and Innovation “Juan de la Cierva-Incorporación” Program (Ref. IJC2020-044108-I). E.M-R. is beneficiary of a PTA Ref. PTA201714619-I. G.G.-A. has been granted a “Ford - Apadrina la Ciencia” contract. C.D.-C has been granted a Fundación Atapuerca fellowship. A.C.A. was funded by Junta de Castilla y León (project BU235P18) and the European Regional Development Fund (ERDF). The Institut Catalá de Paleoecologia Humana i Evolució Social (IPHES-CERCA) has received financial support from the Spanish Ministry of Science and Innovation through the ‘María de Maeztu’ program for Units of Excellence (CEX2019-000945-M).Peer reviewe

Homogenization of linearized elasticity systems with traction condition in perforated domains

In this paper, we study the asymptotic behavior of the linearized elasticity system with nonhomogeneous traction condition in perforated domains. To do that, we use the $H_e^0$-convergence introduced by M. El Hajji in [4] which generalizes - in the case of the linearized elasticity system - the notion of $H^0$-convergence introduced by M. Briane, A. Damlamian and P. Donato in [1]. We give then some examples to illustrate this result

Mathematical modelling and analysis for a three-tiered microbial food web in a chemostat

In this article, we present a mathematical six-dimensional dynamical system involving a three-tiered microbial food web without maintenance. We give a qualitative analysis of the model, and an analysis of the local stability of equilibrium points. Under general assumptions of monotonicity, we prove the uniqueness and the local stability of the positive equilibrium point corresponding to the persistence of the three bacteria. Possibilities of periodic orbits are not excluded and asymptotic coexistence is satisfied