368 research outputs found
Statistical mechanics of warm and cold unfolding in proteins
We present a statistical mechanics treatment of the stability of globular
proteins which takes explicitly into account the coupling between the protein
and water degrees of freedom. This allows us to describe both the cold and the
warm unfolding, thus qualitatively reproducing the known thermodynamics of
proteins.Comment: 5 pages, REVTex, 4 Postscript figure
A Model for the Thermodynamics of Globular Proteins
Comments: 6 pages RevTeX, 6 Postscript figures. We review a statistical
mechanics treatment of the stability of globular proteins based on a simple
model Hamiltonian taking into account protein self interactions and
protein-water interactions. The model contains both hot and cold folding
transitions. In addition it predicts a critical point at a given temperature
and chemical potential of the surrounding water. The universality class of this
critical point is new
Dynamic stabilization of a microwave-driven Josephson tunnel junction against a period-doubling bifurcation
Pathways in Two-State Protein Folding
The thermodynamics of proteins indicate that folding/unfolding takes place
either through stable intermediates or through a two-state process without
intermediates. The rather short folding times of the two-state process indicate
that folding is guided. We reconcile these two seemingly contradictory
observations quantitatively in a schematic model of protein folding. We propose
a new dynamical transition temperature which is lower than the thermodynamic
one, in qualitative agreement with in vivo measurement of protein stability
using E.coli. Finally we demonstrate that our framework is easily generalized
to encompass cold unfolding, and make predictions that relate the sharpness of
the cold and hot unfolding transitions.Comment: 4 pages RevTeX, 5 Postscript figur
Identification of high transverse momentum top quarks in pp collisions at root s=8 TeV with the ATLAS detector
Initial treatment and survival in a national unselected Danish cohort of 4163 patients with pancreatic cancer
Initial treatment and survival in a national unselected Danish cohort of 4163 patients with pancreatic cancer
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