New Bern Buoys its Downtown through Riverwalk Project

The annual conference of the North Carolina Chapter of the American Planning Association (NCAPA) will be held in New Bern this year. This article describes some of the city’s ongoing greening efforts that conference attendees can experience during their visit

The Effect Of Education On Oral Health Students’ Attitudes In Australia And New Zealand

Objective: The aim of this study was to evaluate the oral health attitudes and behavior of students in the oral health curriculum in Australia and New Zealand. Materials and Methods: The Hiroshima University ‑ Dental Behavioral Inventory was administered to students in the first (year 1) and final years (year 3) of the oral health curriculum at Charles Sturt University in Australia and the University of Otago in New Zealand. A total of fifty‑two year 1 students and forty‑five year 3 students completed English version of the questionnaire in 2013. The responses were statistically analyzed by Fisher’s exact tests and exact logistic regression models. Results: The responses of students in years 1 and 3 differed significantly for “I worry about the color of my teeth” at Charles Sturt University and at the University Otago, for “I think my teeth are getting worse despite my daily brushing,” “I put off going to the dentist until I have a toothache,” and “I don’t feel I’ve brushed well unless I brush with strong strokes.” The estimated odds ratios from the exact logistic regression models showed that year 1 students were more likely to agree with above‑mentioned four questions. Conclusions: Oral Health students who had been educated in a 3‑year oral health curriculum in Australia and New Zealand had more positive attitudes and behaviors related oral health than did students at the beginning of their curriculum

Cascade time-scales for energy and helicity in homogeneous isotropic turbulence

We extend the Kolmogorov phenomenology for the scaling of energy spectra in high-Reynolds number turbulence, to explicitly include the effect of helicity. There exists a time-scale $\tau_H$ for helicity transfer in homogeneous, isotropic turbulence with helicity. We arrive at this timescale using the phenomenological arguments used by Kraichnan to derive the timescale $\tau_E$ for energy transfer (J. Fluid Mech. {\bf 47}, 525--535 (1971)). We show that in general $\tau_H$ may not be neglected compared to $\tau_E$, even for rather low relative helicity. We then deduce an inertial range joint cascade of energy and helicity in which the dynamics are dominated by $\tau_E$ in the low wavenumbers with both energy and helicity spectra scaling as $k^{-5/3}$; and by $\tau_H$ at larger wavenumbers with spectra scaling as $k^{-4/3}$. We demonstrate how, within this phenomenology, the commonly observed ``bottleneck'' in the energy spectrum might be explained. We derive a wavenumber $k_h$ which is less than the Kolmogorov dissipation wavenumber, at which both energy and helicity cascades terminate due to dissipation effects. Data from direct numerical simulations are used to check our predictions.Comment: 14 pages, 5 figures, accepted to Physical Review

Job satisfaction and career prospects of Oral Health Therapists in Aotearoa/New Zealand: A research update and call for further research in light of the COVID-19 pandemic

Peer Reviewe

Urban Greening in North Carolina: Case Studies from New Bern, Mecklenburg County, and Raleigh

Carolina Planning regularly solicits articles on recent projects from members of the North Carolina chapter of the American Planning Association (NCAPA). This year’s submissions focused on water resource management – an important element of urban greening efforts. From a riverwalk in New Bern – the host city for the 2010 NCAPA Conference – to a stream restoration project in Mecklenburg County and an educational wetlands park in Raleigh, these projects provide valuable insight into the local planning process

Decision-making and referral processes for patients with motor neurone disease: a qualitative study of GP experiences and evaluation of a new decision-support tool

Background The diagnosis of motor neurone disease (MND) is known to be challenging and there may be delay in patients receiving a correct diagnosis. This study investigated the referral process for patients who had been diagnosed with MND, and whether a newly-developed tool (The Red Flags checklist) might help General Practitioners (GPs) in making referral decisions. Methods We carried out interviews with GPs who had recently referred a patient diagnosed with MND, and interviews/surveys with GPs who had not recently referred a patient with suspected MND. We collected data before the Red Flags checklist was introduced; and again one year later. We analysed the data to identify key recurring themes. Results Forty two GPs took part in the study. The presence of fasciculation was the clinical feature that most commonly led to consideration of a potential MND diagnosis. GPs perceived that their role was to make onward referrals rather than attempting to make a diagnosis, and delays in correct diagnosis tended to occur at the specialist level. A quarter of participants had some awareness of the newly-developed tool; most considered it useful, if incorporated into existing systems. Conclusions While fasciculation is the most common symptom associated with MND, other bulbar, limb or respiratory features, together with progression should be considered. There is a need for further research into how decision-support tools should be designed and provided, in order to best assist GPs with referral decisions. There is also a need for further work at the level of secondary care, in order that referrals made are re-directed appropriately

HSV-1 Remodels Host Telomeres to Facilitate Viral Replication

SummaryTelomeres protect the ends of cellular chromosomes. We show here that infection with herpes simplex virus 1 (HSV-1) results in chromosomal structural aberrations at telomeres and the accumulation of telomere dysfunction-induced DNA damage foci (TIFs). At the molecular level, HSV-1 induces transcription of telomere repeat-containing RNA (TERRA), followed by the proteolytic degradation of the telomere protein TPP1 and loss of the telomere repeat DNA signal. The HSV-1-encoded E3 ubiquitin ligase ICP0 is required for TERRA transcription and facilitates TPP1 degradation. Small hairpin RNA (shRNA) depletion of TPP1 increases viral replication, indicating that TPP1 inhibits viral replication. Viral replication protein ICP8 forms foci that coincide with telomeric proteins, and ICP8-null virus failed to degrade telomere DNA signal. These findings suggest that HSV-1 reorganizes telomeres to form ICP8-associated prereplication foci and to promote viral genomic replication

A Review of the Global Literature on Dental Therapists: In the Context of the Movement to Add Dental Therapists to the Oral Health Workforce in the United States (Executive Summary)

This executive summary documents evidence that dental therapists can effectively expand access to dental care, especially for children, and is technically competent, safe and effective

Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens

Neuroblastoma (NB) is the most deadly extra-cranial solid tumour in children necessitating an urgent need for effective and less toxic treatments. One reason for the lack of efficacious treatments may be the inability of existing drugs to target the tumour-initiating or cancer stem cell population responsible for sustaining tumour growth, metastases and relapse. Here, we describe a strategy to identify compounds that selectively target patient-derived cancer stem cell-like tumour-initiating cells (TICs) while sparing normal paediatric stem cells (skin-derived precursors, SKPs) and characterize two therapeutic candidates. DECA-14 and rapamycin were identified as NB TIC-selective agents. Both compounds induced TIC death at nanomolar concentrations in vitro, significantly reduced NB xenograft tumour weight in vivo, and dramatically decreased self-renewal or tumour-initiation capacity in treated tumours. These results demonstrate that differential drug sensitivities between TICs and normal paediatric stem cells can be exploited to identify novel, patient-specific and potentially less toxic therapies