A first case of fixed drug eruption due to Tamsulosin

Background: Fixed Drug Eruption (FDE) is a drug reaction involving the skin and less commonly the mucosal membranes. Tamsulosin is an alpha-1 adrenergic receptor blocker used to treat benign prostatic hyperplasia. Dizziness and headache are among its most common side effects (Singapore Med J, 2018;59:336). Although cutaneous drug eruption has been reported with other alpha-1 adrenergic receptor blockers. Aims: Drug rash due to Tamsulosin is relatively uncommon (Singapore Med J, 2018;59:336). In this case we report an incidence of fixed drug eruption due to Tamsulosin. Patients: A 54 year old male, with benign prostatic hyperplasia was referred to our office for evaluation of certain eruptions, having developed his hyper-pigmented patches after 2 weeks of using oral 0.4 mg Tamsulosin per day. Based on the clinical course and the skin biopsy we diagnosed the condition as Tamsulosin associated fixed drug eruption. The most important therapeutic measure was discontinuing Tamsulosin medication. Following this, his eruptions improved remarkably in a few days without complications. Results: According to previous findings, there has been no case report on fixed drug eruption caused by Tamsulosin. Conclusion: Our case is a relatively mild form of fixed drug eruption. Therefore it should be kept in mind that a severe cutaneous drug eruption might occur after Tamsulosin administration. © 2019 Wiley Periodicals, Inc

Evaluation of Metal Pollution in Groundwater in the Industrialized Environs in and Around Dindigul, Tamilnadu, India

Synoptic hydrogeochemical assessments of physico-chemical and metal concentrations were analyzed to understand the driving forces behind heavy and trace metal pollution dynamics in groundwater systems of the heavily industrialized Dindigul district of Tamilnadu (India). Seasonality in solute dynamics is mainly due to regional differences in recharging capacity of groundwater systems and associated hydrogeochemical processes. Rapid changes in land use coupled with industrialization result in contamination of groundwater with heavy and trace metals like Be, Cr, Mn, Zn, Mo, Ni, Co, As, Cu, Cd, Pb, and Fe. The Pearson correlation and the Principal Component Analysis demonstrate that the complex suite of multidimensional metal pollution sources is influencing the groundwater quality in this region. In addition, pollution indices like heavy metal pollution index (HPI), heavy metal evaluation index (HEI), and contamination factor (Cd) were used to characterize the groundwater quality with reference to the water quality standards. All results demonstrate that the Dindigul groundwater quality is severely polluted by a large suite of metals like Be, Cr, Mn, Zn, Mo, Ni, Co, As, Cu, Cd, Pb, and Fe. Hence stringent management policies are highly required to control the industrial pollution and to improve the regional groundwater quality for sustainable development of the regional environment