PLACEBO-CONTROLLED STUDY ON COMPARISON OF TWO HERBAL HYPOLIPIDEMIC AGENTS

Introduction: Hyperlipidemia, either primary or secondary causes atherogenetic abnormalities leading to coronary artery disease, cardiac arrest and arrhythmias. Herbal therapy for prevention or cure of Hyperlipidemia is replacing allopathic medicine due to their bioequivalence and good compliance features. This study was conducted to compare hypolipidemic effects of Garlic and Nigella sativa. Place of Study: Study was conducted at Jinnah Hospital Lahore from July 2013 to December 2013. Seventy five hyperlipidemic patients were enrolled after getting written consent which was approved by Ethics committee of the hospital. Grouping: They were divided in three equal groups comprising 25 patients in each group. Group-A was treated by Nigella Sativa, Group-B was advised to take Garlic 10 grams twice daily for two months. Group-C was on placebo. Results: After two months therapy it was observed by statistical analysis that Nigella sativa decreased total cholesterol 12.4 mg/dl, triglycerides 16.7 mg/dl, and LDL cholesterol 27.3 mg/dl. HDL rise was 5.2 mg/dl. Garlic decreased total cholesterol 17.9 mg/dl, triglycerides 19.9 mg/dl and LDL cholesterol 14.8 mg/dl. HDL cholesterol rise was 8.0 mg/dl. Conclusion: It was concluded from this study that there is little difference between hypolipidemic effects of two important and famous herbal medicines ie, Nigella sativa and Garlic

COMPARATIVE CHARACTERIZATION OF ANTIOXIDANT PROFILE OF VITAMIN-E AND RED DATES IN PLACEBO AND TESTED GROUPS OF HYPERLIPIDEMIC PATIENTS

Objective: Antioxidants are nutrients that help minimize free-radical damage to the body. Free radicals are highly reactive compounds that are created in the body during normal metabolic functions or introduced from the environment, such as by exposure to pollution and other toxins. Inherently unstable, free radicals contain "extra" energy which they try to reduce by reacting with certain chemicals in the body, which interferes with the cells' ability to function normally. Current study compared antioxidant characteristics of vitamin-E and red Dates. It was placebo-controlled conducted study conducted at general hospital Methods: Lahore Pakistan from January 2018 to March 2018. LDL-cholesterol was calculated as total cholesterol- HDL-cholesterol-VLDL-cholesterol; VLDL-cholesterol was measured directly after ultracentrifugation. After one month therapy their post treatment lipid profile was determined and analyzed statistically by using SPSS version 2.2.01 2013. Paired ‘t’ test was applied for mean values with SD of the parameters before and after treatment. Results: Results showed highly significant change in LDL-cholesterol of group-II patients but HDL-cholesterol was increased 6.6 mg/dl, still it was significant change with p-value of <0.01. In group-III LDL-cholesterol was decreased 10.9 mg/dl which is significant change with p-value <0.01. HDL-cholesterol in this group was increased 4.2 mg/dl which is non significant with p-value of >0.05. Conclusion: Study concluded that red dates have antioxidant potential by lowering LDL-cholesterol in human plasma. But this effect is not comparable with hypolipidemic effects of Vitamin E as it also increases good cholesterol i.e. HDL-cholesterol.                      Peer Review History: Received 14 June 2019;   Revised 5 July; Accepted 9 July, Available online 15 July 2019 Academic Editor: Rola Jadallah, Arab American University, Palestine, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, [email protected] Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, [email protected]  Similar Articles: PHYTOCHEMICAL SCREENING AND IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY POTENTIAL EVALUATIONS OF METHANOLIC EXTRACTS OF COCOS NUCIFERA (L.) LEAVES ANTIHYPERGLYCEMIC AND ANTI-OXIDANT POTENTIAL OF ETHANOL EXTRACT OF VITEX THYRSIFLORA LEAVES ON DIABETIC RATS PHYTOCHEMICAL SCREENING AND IN VITRO ANTIOXIDANT AND ANTI-DIABETIC POTENTIALS OF PERSEA AMERICANA MILL. (LAURACEAE) FRUIT EXTRACT ANTI-HYPERGLYCEMIC AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF GONGRONEMA LATIFOLIUM ANTI-INFLAMMATORY AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF BAPHIA NITIDA ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY OF PSIDIUM GUAJAVA. (GUAVA) MEDICINAL PLANT LEAVES USED IN FOLK MEDICINE FOR TREATMENT OF WOUNDS AND BURNS IN HUFASH DISTRICT AL MAHWEET GOVERNORATE–YEME

FLAXSEEDS AND AJWAIN FOR PRIMARY HYPERLIPIDEMIA

Research work was single blind placebo-controlled, conducted at General Hospital, Lahore, Pakistan conducted from NOVEMBER 2015 to JANUARY 2016. 75 diagnosed primary  hyperlipidemic patients were selected with age range from 20 to 60 years. Diabetes mellitus, cigarette smoking/alcohol addictive patients, peptic ulcer disease, hypothyroidism, kidney dysfunction, any heart disease and liver disease. All patients were divided in three groups, ie;  25 in each group. All participant’s baseline lipid profile data were taken and filed in specifically designed Performa, at start of taking medicine. Twenty five patients of group-I were advised to take 10 grams of Flaxseeds in three divided doses after meal. Twenty five patients of group-II were advised to take Ajwain seeds 10 grams in three divided doses after each meal for two months. Twenty five patients of group-III were provided placebo capsules, (containing grinded rice), taking one capsule after each meal. All participants were advised to take these medicines for eight weeks. Followup period: All participants were called fortnightly for their query and  follow up. Their LDL-cholesterol, and HDL-cholesterol was determined at the hospital laboratory. In two months therapy by Flaxseeds decreased LDL-cholesterol 6.2 % and increased HDL-cholesterol 7.7 %. Ajwain reduced LDL-cholesterol 8.9 % and HDL-cholesterol increased 13.1 %. All changes are biostatistically significant with p-value of <0.01. Conclusion: It was concluded from the research that both Flaxseeds and Ajwain are effective in Primary Hyperlipidemia, if used for two months with specific concentrations

Plants and therapeutics: Interaction

Medicinal herbs are getting popularity due to their good compliance on the basis of their ethnic utilization and lesser side effects. Plasma lipids in body include, cholesterol, triglycerides, very low density lipoprotein-cholesterol, low density lipoprotein-cholesterol, and high density lipoprotein-cholesterol. High levels of LDL-cholesterol and lower levels of HDL-cholesterol may cause oxidation in plasma leading to formation of atherogenic plaques which are main etiological factors for development of Coronary Artery Diseases (CAD). Many hypolipidemic herbs are being used to prevent CAD. We have used AJWAIN, Alsi separately and in combination to observe their hypolipidemic potential. Study was conducted at Jinnah Hospital Lahore-Pakistan from March 2015 to July 2015. One hundred hyperlipidemic patients were selected from lipid research clinic of Jinnah Hospital, Lahore-Pakistan, and approved written consent was taken from all patients. They were divided in four equal groups comprising 25 patients in each group. Group-I was treated by AJWAIN for three months, Group-II was treated by ALSI, Group-III was treated by AJWAIN plus Alsi for the period of three months. After three months therapy it was observed that AJWAIN reduced LDL-cholesterol 23.77mg/dl and increased HDL-cholesterol 3.3mg/dl. ALSI reduced LDL-cholesterol 7.5mg/dl and increased HDL-cholesterol 5.3mg/dl. Whereas combination of both agents decreased LDL-cholesterol 16.1mg/dl and increased HDL-cholesterol 6.6mg/dl in three months therapy. It was concluded from this research work that ALSI and AJWAIN given separately or in combination, have good enough potential to reduce LDL-cholesterol but are less potent effect on HDL-cholesterol in hyperlipidemic patients.&nbsp;</p