Entrepreneurship in New York: The Mismatch between Venture Capital and Academic R&D

The Entrepreneurship in New York study is a joint venture of the SUNY Levin Institute, the Research Foundation of SUNY, and SUNY Geneseo. This study shows that New York now commands a larger share of national venture investment than in past studies. Although, within this picture a significant disconnect is revealed. New York’s strong performance in academic R&D in the sciences stands in contrast with the relatively modest amounts of private investment available to move these innovations forward commercially. In 2012, 85% of the venture capital invested in New York State firms was invested in information technology and creative and commerce services, while 15% was invested in the life and physical sciences. By contrast, 89% of academic R&D expenditures in New York State were in the life and physical sciences, with only small amounts invested in IT. Authors Judith Albers, PhD, and Thomas R. Moebus feature important data and analysis that conclude increased investment in the life and physical sciences are needed. They identify specific opportunities for NYC and other investors that emerge as part of START-UP NY and other state initiatives.https://knightscholar.geneseo.edu/geneseo-authors/1002/thumbnail.jp

I. The Use of Polyethers as Phase Transfer Catalysts for the Fluoroalkoxylation of Halogenated Aromatic and Heteroaromatic Systems II. The Grignard Addition and Sodium Cyanoborohydride Reduction of Arylchloropropeniminium Salts

This research addresses two distinct areas of synthetic organic chemistry: the use of phase transfer catalysts for the fluoroalkoxylation of activated haloaromatic and haloheteroaromatic systems, as well as the Grignard addition and sodium cyanoborohydride reduction of aryl chloropropeniminium salts. In Part I of this research, a number of macrocyclic- and linear polytethers were studied as phase transfer catalysts in the nucleophilic aromatic substitution of haloaromitc systems. The most effective catalyst was determined to be poly(ethylene glycol)-8000 and the reaction conditions were optimized for this catalyst. Subsequently isomer reactivity, effects of activating groups, effects of leaving groups, and nucleophiles were studied with respect to the selective fluoroalkoxylation of various halogenated aromatic substrates. In Part II, a series of 3-chloro-3-aryl-prop-2-en-lyliden-dimethyliminium perchlorates were synthesized, isolated, and subsequently their regio-chemistry was studied with reducing agents and with Grignard reagents. The results indicated that reduction and Grignard addition occurred at the imine (C=N) carbon to form the corresponding N, N-dialkyl allylic amines

Die soziale Versorgung im badischen Heerwesen und ihre Politik 1771 bis 1848/53. Soziale Verpflichtung oder staatspolitisches Kalkül?

Versorgung von Militärinvaliden in Bade

Neighbourhood socio-economic status and positive affectivity among older residents in Germany: a cross-sectional analysis with data from the Heinz Nixdorf Recall Study

Background: Physical and social neighbourhood characteristics can vary according to the neighbourhood socio-economic status (SES) and influence residents’ perceptions, behaviours and health outcomes both positively and negatively. Neighbourhood SES has been shown to be predictive of mental health, which is relevant for healthy ageing and prevention of dementia or depression. Positive affectivity (PA) is an established indicator of mental health and might indicate a positive emotional response to neighbourhood characteristics. In this study, we focussed on the association of neighbourhood SES with PA among older residents in Germany and considered social integration and environmental perceptions in this association. Methods: We used questionnaire-based data of the ongoing population-based Heinz Nixdorf Recall Study for our cross-sectional analysis, complemented by secondary data on social welfare rates in the neighbourhood of residents’ address. PA was assessed using the Positive and Negative Affect Schedule (PANAS) in 2016. Linear regression models were performed to estimate the associations and adjusted for socio-demographic variables. Results: Higher social welfare rates were associated with lower PA scores. The strongest negative association from the crude model (b = -1.916, 95%-CI [-2.997, -0.835]) was reduced after controlling for socio-demographic variables (b = -1.429, 95%-CI [-2.511, -0.346]). Social integration factors (b = -1.199, 95%-CI [-2.276, -0.121]) and perceived environmental factors (b = -0.875, 95%-CI [-1.971, 0.221]) additionally diminished the association of social welfare rates with PA in the full model (b = -0.945, 95%-CI [-2.037, 0.147]). Conclusion: Our results suggest that neighbourhoods have an influence on the occurrence and the extent of PA. Public health interventions that address socio-economic disadvantage in the neighbourhood environment could be an effective and far-reaching way to reduce the risk of depression and depressive symptoms due to low PA in older residents

Acoustic Quality and Health in Urban Environments – The SALVE Project

Background sounds of urban regions have been a concern of architecture and construction engineering for years. In the context of health research however, sound has been restricted to the health risk factor noise, thus reduced to sound decibel levels. Accordingly, noise mitigation measures aim exclusively at the reduction of noise level below a certain threshold. Soundscapes on the other hand, comprise all acoustic events of the natural, physical and human environment, which are determined by sound level, frequency, time and space. Soundscape Ecology which includes the study of spatio-temporal heterogeneity of sounds in different landscapes, provides a suitable methodical approach to analyse the relationships between soundscapes, the built environment and human health. This paper presents SALVE (Acoustic Quality and Health in Urban Environments), a two year interdisciplinary pilot project that started in October 2018 and involves the disciplines of public health and spatial planning. The project aims at the identification of criteria for health-promoting soundscapes in cities. By making year long direct and automated auditory measurements of a robust landuse sample in the city of Bochum, located in the highly urbanized Ruhr Area of Germany, one of the largest multi-seasonal urban soundscape datasets will be generated. These data will be merged with health data from the longitudinal, population-based Heinz Nixdorf Recall (HNR) study. Spatio-statistical models will be further developed to analyse health effects of different types of soundscapes in urban neighborhoods. The project serves as a starting point for an innovative and comprehensive approach to understanding the effects of sound quality on urban public health beyond noise protection. Additionally, knowledge will be gained for the development of solution based health-promoting strategies in spatial planning

Adding epoetin alfa to intense dose-dense adjuvant chemotherapy for breast cancer : randomized clinical trial

BACKGROUND: The AGO-ETC trial compared 5-year relapse-free survival of intense dose-dense (IDD) sequential chemotherapy with epirubicin (E), paclitaxel (T), and cyclophosphamide (C) (IDD-ETC) every 2 weeks vs conventional scheduled epirubicin/cyclophosphamide followed by paclitaxel (EC→T) (every 3 weeks) as adjuvant treatment in high-risk breast cancer patients. The objective of this study was to evaluate the safety and efficacy of epoetin alfa in a second randomization of the intense dose-dense arm. METHODS: One thousand two hundred eighty-four patients were enrolled; 658 patients were randomly assigned to the IDD-ETC treatment group. Within the IDD-ETC group, 324 patients were further randomly assigned to the epoetin alfa group, and 319 were randomly assigned to the non-erythropoiesis-stimulating agent (ESA) control group. Primary efficacy endpoints included change in hemoglobin level from baseline to Cycle 9 and the percentage of subjects requiring red blood cell transfusion. Relapse-free survival, overall survival, and intramammary relapse were secondary endpoints estimated with Kaplan-Meier and Cox regression methods. Except for the primary hypothesis, all statistical tests were two-sided. RESULTS: Epoetin alfa avoided the decrease in hemoglobin level (no decrease in the epoetin alfa group vs -2.20g/dL change for the control group; P < .001) and statistically significantly reduced the percentage of subjects requiring red blood cell transfusion (12.8% vs 28.1%; P < .0001). The incidence of thrombotic events was 7% in the epoetin alfa arm vs 3% in the control arm. After a median follow-up of 62 months, epoetin alfa treatment did not affect overall survival, relapse-free survival, or intramammary relapse. CONCLUSIONS: Epoetin alfa resulted in improved hemoglobin levels and decreased transfusions without an impact on relapse-free or overall survival. However, epoetin alfa had an adverse effect, resulting in increased thrombosis

Indigenous practices of are production.

O artigo apresenta fragmentos do percurso de uma pesquisa sobre pr?ticas ind?genas de cuidado entre os yawanaw?s da amaz?nia acreana, na qual se p?de problematizar alguns conceitos chaves, como: ?saberes tradicionais?, ?medicina ind?gena? e ?pr?ticas integrativas?. Utilizou-se a metodologia da pesquisa qualitativa participativa, com entrevistas densas n?o estruturadas e di?rio de campo. Conclui-se que as pr?ticas ind?genas de produ??o de cuidado participam de uma vis?o de mundo intuitiva, relacional e integral. E que a ideia de incluir essas pr?ticas de cuidado no rol das pr?ticas integrativas, ao mesmo tempo que as valoriza, traz o risco de transform?-las em algo mais utilitarista, funcionalista e objetivo do que de fato s?o.The article presents some fragments of the journey of a care practices? research among the yawanaw?s of amazon acreana, which we could think about some key concepts, like: ?traditional knowledge?, ?indigenous medicine? and ?integrative practices?. Qualitative research methodology was used, with dense unstructured interviews and field diary. It follows that care production?s indigenous practices take part in a intuitive, relational, and integral world?s vision. And this ideia of includes this care practices in integrative practices list, at the same time that valorizate it, brings the risk of turn it into something more utilitarian, functionalist and objective than it is in fact