15 research outputs found
Raised Serum Markers of T Cell Activation and Exhaustion in Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency
Get PDFPurpose About 20–30% of patients with common variable immunodefciency (CVID) develop granulomatous-lymphocytic
interstitial lung disease (GLILD) as one of several non-infectious complications to their immunodefciency. The purpose
of this study was to identify biomarkers that could distinguish GLILD from other non-infectious complications in CVID.
Methods We analyzed serum biomarkers related to infammation, pulmonary epithelium injury, fbrogenesis, and extracellular matrix (ECM) remodeling, and compared three subgroups of CVID: GLILD patients (n=16), patients with other
non-infectious complications (n=37), and patients with infections only (n=20).
Results We found that GLILD patients had higher levels of sCD25, sTIM-3, IFN-Îł, and TNF, refecting T cell activation
and exhaustion, compared to both CVID patients with other infammatory complications and CVID with infections only.
GLILD patients also had higher levels of SP-D and CC16, proteins related to pulmonary epithelium injury, as well as the
ECM remodeling marker MMP-7, than patients with other non-infectious complications.
Conclusion GLILD patients have elevated serum markers of T cell activation and exhaustion, pulmonary epithelium injury,
and ECM remodeling, pointing to potentially important pathways in GLILD pathogenesis, novel targets for therapy, and
promising biomarkers for clinical evaluation of these patients
Erstatning, afgifter og andre ikke-pønale retfølger som alternativer til bødestraf
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Om strafudmĂĄlingen ved betingede domme med udsat straffuldbyrdelse
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