High Dimensional Classification with combined Adaptive Sparse PLS and Logistic Regression

Motivation: The high dimensionality of genomic data calls for the development of specific classification methodologies, especially to prevent over-optimistic predictions. This challenge can be tackled by compression and variable selection, which combined constitute a powerful framework for classification, as well as data visualization and interpretation. However, current proposed combinations lead to instable and non convergent methods due to inappropriate computational frameworks. We hereby propose a stable and convergent approach for classification in high dimensional based on sparse Partial Least Squares (sparse PLS). Results: We start by proposing a new solution for the sparse PLS problem that is based on proximal operators for the case of univariate responses. Then we develop an adaptive version of the sparse PLS for classification, which combines iterative optimization of logistic regression and sparse PLS to ensure convergence and stability. Our results are confirmed on synthetic and experimental data. In particular we show how crucial convergence and stability can be when cross-validation is involved for calibration purposes. Using gene expression data we explore the prediction of breast cancer relapse. We also propose a multicategorial version of our method on the prediction of cell-types based on single-cell expression data. Availability: Our approach is implemented in the plsgenomics R-package.Comment: 9 pages, 3 figures, 4 tables + Supplementary Materials 8 pages, 3 figures, 10 table

Identificação de novos inibidores de urease de interesse agrícola.

FertBio 2014

Eficiência no solo e estabilidade térmica de novos inibidores de urease.

FertBio 2014

Schiff bases: A short review of their antimicrobial activities

AbstractSchiff bases are aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This short review compiles examples of the most promising antimalarial, antibacterial, antifungal, and antiviral Schiff bases. An overview of synthetic methodologies used for the preparation of Schiff bases is also described

Efeito de novos inibidores de urease no desenvolvimento de Pennisetum glaucum L.

FertBio 2014

Energy demand and distribution of corn seeds as a function of the speed of two seedrills

This work had the objective of evaluating the distribution uniformity of corn seed in two displacement speeds and two precision seedrills, in an experiment conducted in a Oxisol, with slightly inclined relief in a loamy soil. The experimental design was constituted of four treatments composed of two seeders (S1 - PSE 8/Semeato and S2 - PST 2/Super Tatu) and two velocity of seedrills (V1 = 5.2 and V2 = 8.1 km h-1). The mean value of the traction force in the bar was 9.6 kN for S1 and 8.07 kN for S2, while the slippage was 5.83 and 4.26%, for S1 and S2, respectively. The values obtained for distribution uniformity of seeds of the seeder S1 in the speeds V1 and V2 were 21.6 and 22.0, and for the seeder S2 18.0 and 19.0 cm respectively, which did not differ statistically; however for the two displacement speeds a tendency of increase of the spacing among plants with the speed increase was verified.Objetivou-se, através deste trabalho, avaliar a uniformidade de distribuição de sementes de milho em duas velocidades de deslocamento de duas semeadoras-adubadoras de precisão, em experimento conduzido em um Latossolo Vermelho distroférrico, de relevo levemente inclinado e textura muito argilosa. O delineamento experimental constituiu-se de quatro tratamentos compostos de duas semeadoras (S1-PSE 8/Semeato, S2-PST 2/Super Tatu) e duas velocidades de deslocamento (V1 = 5,2 e V2 = 8,4 km h-1). O valor médio da força de tração na barra foi de 9,6 kN para S1 e 8,07 kN para S2, enquanto a patinagem foi de 5,83 e 4,26%, para S1 e S2, respectivamente. Os valores obtidos para o espaçamento entre sementes da semeadora S1 nas velocidades V1 e V2, foram 21,6 e 22,0 e, para a semeadora S2, 18,0 e 19,0 cm respectivamente, os quais não diferiram estatisticamente entre si; verificou-se, entretanto, para as duas velocidades de deslocamento, tendência de aumento dos espaçamentos entre plantas, com o aumento da velocidade.42442

Programa de melhoramento genético de pupunha na Embrapa, IAC e INPA.

Estado da arte; Recursos genéticos; Estratégias de melhoramento; Desenvolvimento experimental.bitstream/item/30975/1/Doc205.pd

Study of the hydrogen escape rate at Mars during Martian years 28 and 29 from comparisons between SPICAM/Mars Express observations and GCM-LMD simulations

EPSC-DPS Joint Meeting 2019, held 15-20 September 2019 in Geneva, Switzerland, id. EPSC-DPS2019-499-2.- © Author(s) 2019. CC Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/deed.esWe simulate the 3D Martian hydrogen corona during the Martian years 28 and 29 at different solar longitudes using a set of models of atomic hydrogen density from the surface to the exosphere. These simulations are compared to Mars Express / SPICAM observations and show a strong underestimate of the brightness by our models near southern summer that could be due to an underestimate of the amount of water vapor delivered to the upper atmosphere at this season