Synthesis and process optimization of electrospun PEEK-sulfonated nanofibers by response surface methodology

In this study electrospun nanofibers of partially sulfonated polyether ether ketone have been produced as a preliminary step for a possible development of composite proton exchange membranes for fuel cells. Response surface methodology has been employed for the modelling and optimization of the electrospinning process, using a Box-Behnken design. The investigation, based on a second order polynomial model, has been focused on the analysis of the effect of both process (voltage, tip-to-collector distance, flow rate) and material (sulfonation degree) variables on the mean fiber diameter. The final model has been verified by a series of statistical tests on the residuals and validated by a comparison procedure of samples at different sulfonation degrees, realized according to optimized conditions, for the production of homogeneous thin nanofibers

Mixed reality for cross-cultural integration. Using positive technology to share experiences and promote communication

The opinion article highlights some innovative resources to deal with the challenges of migrations, relying in the field of positive technologies and, more specifically, in the concept of mixed reality. In the contemporary society, migrations are a common phenomenon that rises cultural and psycho-social issues, as well as political and economic challenges. People move from their place of origin for educational or professional purposes or because they are forced to leave due to political, economic and social conditions, and also natural disasters which produce population flows. Whatever the push and pull factors are, when people move permanently or temporarily they tend to maintain close ties with their place of origin (with people, places, culture, practices etc.), while trying to develop attachment with the place of residence. Immigrants construct their identities in the context of a negotiation between old and new homes’ contexts. However, such a process is not free from issues and relevant consequences on immigrants’ well-being. Some psychosocial issues can be identified regarding identity re-negotiation while moving to a different place, and cultural integration: immigrants could experience feeling of isolation, estrangement and alienation, related to the difficulty to create strong social ties in the new place; the “acculturation stress” associated to adaptation to new culture, language and practices. Positive technologies offer innovative resources to deal with these challenges, by considering the human health and well-being as the main objective for technological advancement. In a broad sense, Positive technology may be used to structure, augment or replace user experience with digital content; also, positive devices may be used to promote positive emotions (hedonic technology), to support the user in the achievement of engaging and self-actualizing experiences (eudaimonic technology), and to enhance connectedness among individuals, groups and societies (social-interpersonal technologies). In such perspective, the mixed reality technology provides resources for intervention in that it is based on the addition of digital elements in the physical environment, instead of its substitution with an immersive experience which, in this case, may act as a palliative care for sadness but does not help to integrate oneself in a new, “real” physical environment and social context. Specifically, mixed reality based Positive technologies can help in maintaining the relation with the home country, and also in fostering the inclusion in and attachment to the receiving society, by providing users with sources of identification that stretch beyond the national and local contexts of their old and new homes. Addressing the social connectedness, the mixed reality can provide the medium to share the meanings that people attach to places, people and cultures, and creating belonging in the receiving society. Indeed, people can better approach the receiving society by understanding the cultural meanings connected with places, history and activities. The concept expressed in the opinion article is still in its infancy. However, it provides an innovative idea for positive technology (at the social-interpersonal level), which may guide the development of future devices and applications for enhancing health and well-being in the growing population looking for a new life in places distant from home

Electrically Conductive Membranes Obtained by Simultaneous Electrospinning and Electrospraying Processes

Electrically conductive polyurethane nanostructured membranes have been prepared combining the electrospinning of polymer nanofibers (NFs) with the electrospraying of pristine multiwall carbon nanotubes (MWCNTs) in simultaneous processes. In order to have a better understanding of the distribution of MWCNTs on the surface of the membranes, the optimization of the electrospraying process has been carried out and the distribution of MWCNTs has been evaluated using image texture analysis techniques. Large membranes with a volume resistivity typical of electrostatic discharge materials with a MWCNTs concentration less than 0.3% wt (0.01 mg/cm2) have been obtained and characterized with morphological (SEM and TEM) and spectroscopic (UV-Vis, Raman) techniques

Adiponectin Signaling Pathways in Liver Diseases

In the liver, adiponectin regulates both glucose and lipid metabolism and exerts an insulin-sensitizing effect. The binding of adiponectin with its specific receptors induces the activation of a proper signaling cascade that becomes altered in liver pathologies. This review describes the different signaling pathways in healthy and diseased hepatocytes, also highlighting the beneficial role of adiponectin in autophagy activation and hepatic regeneration

Hyperglycemia and angiotensin II cooperate to enhance collagen I deposition by cardiac fibroblasts through a ROS-STAT3-dependent mechanism

AbstractCardiac fibroblasts significantly contribute to diabetes-induced structural and functional changes in the myocardium. The objective of the present study was to determine the effects of high glucose (alone or supplemented with angiotensin II) in the activation of the JAK2/STAT3 pathway and its involvement in collagen I production by cardiac fibroblasts. We observed that the diabetic environment 1) enhanced tyrosine phosphorylation of JAK2 and STAT3; 2) induced nuclear localization of tyrosine phosphorylated STAT3 through a reactive oxygen species-mediated mechanism, with angiotensin II stimulation further enhancing STAT3 nuclear accumulation; and 3) stimulated collagen I production. The effects were inhibited by depletion of reactive oxygen species or silencing of STAT3 in high glucose alone or supplemented with exogenous angiotensin II. Combined, our data demonstrate that increased collagen I deposition in the setting of high glucose occurred through a reactive oxygen species- and STAT3-dependent mechanism. Our results reveal a novel role for STAT3 as a key signaling molecule of collagen I production in cardiac fibroblasts exposed to a diabetic environment