Effect of progressive prone plank exercise program on diastasis of rectus abdominis muscle in postpartum women: A randomized controlled trial

Diastasis of Rectus Abdominis (DRA) muscle is a concerning health issue that commonly affects female within pregnancy and postpartum time, persistent lower back pain and pelvic instability are common consequences to DRA. Thus, this study was conducted to examine the effect of progressive prone plank exercises on narrowing the inter-Rectus distance (IRD) in postpartum women diagnosed with (DRA). A prospective, randomized, single-blind, controlled trial was conducted at the Faculty of Physical Therapy Clinic of Beni-Suef University. Fifty postpartum women presented with (DRA) of at least 2 finger widths assigned into 2 equal groups (A&B). A Toshiba Xario100, 8–12 MHz ultrasonography was used to accurately measure IRD before and after 8 weeks of the exercise program. Group (A), received progressive prone plank exercise program and advice relevant to DRA as well as wore abdominal binder, while group (B) continued their ordinary lifestyle after receiving advice and wearing abdominal binder as group (A).The study results revealed a statistical significant decrease within each group and between groups in IRD (p < .05) above and below the umbilicus both at rest and during Rectus Abdominis (RA) contraction, with a significantly narrower IRD in favoured of participants of group (A) (p < .05). To sum it up, progressive prone plank exercise program is very effective in decreasing IRD in postpartum women presented with DRA

Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds

An efficient synthesis of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide (3) has been achieved and described. The obtained hydrazide (3) was used in building of some interesting heterocycles such as, triazole, oxadiazole, pyrazole, phthalazine, and indol-2-one rings at position 3. The structures of the obtained compounds were confirmed by IR, 1H NMR, 13C NMR, MS spectral and elemental analysis

Successful Conservative Management of Scrotal Edema Resulting from Uncomplicated Peritoneal Fluid Leak

Introduction: Peritoneal fluid leaks are frequent in continuous ambulatory peritoneal dialysis (CAPD) patients and may manifest as subcutaneous or genital edema or as apparent ultrafiltration (UF) failure. Genital swelling in CAPD patients is often due to dialysate leak through a small clinically-undetectable inguinal hernia, and may require herniorrhaphy. If imaging studies exclude an associated hernia or patent processus vaginalis, a conservative approach may be adopted. Case report: An 80 year-old bed-ridden male developed gross bilateral scrotal swelling (without cough impulse) and apparent UF failure shortly after initiation of CAPD. Computed tomography peritoneography (CTP) showed bilateral scrotal fluid collections without a hernia or patent processus vaginalis. An attempt to maintain the patient on CAPD by reducing the dialysate volume, scrotal elevation and adopting a supine position was not successful; CAPD was substituted with temporary hemodialysis (HD) for four weeks. Scrotal swelling reversed after one week of CAPD cessation and did not recur when supine PD with intermittent dry periods was reinstituted a few weeks later. Satisfactory UF could also be easily attained. This was compatible with caudal fluid migration through peritoneal defects being the underlying cause. The patient had been successfully maintained on CAPD for the last 18 months. Conclusion: Fluid dissection through soft tissues can result in gross genital edema and apparent ultrafiltration failure in CAPD patients. Supine PD, scrotal elevation with intermittent dry periods may be a practical alternative management in the absence of automated dialysis facilities. The severity of dialysate leak does not preclude a satisfactory response to this conservative management. Keywords: peritoneal dialysis, dialysate leak, genital edema, ultrafiltration failur

A case of molecularly profiled extraneural medulloblastoma metastases in a child

Background: Extraneural metastases are relatively rare manifestations of medulloblastoma. Case presentation: We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options. Conclusion: To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child

An above-knee compression garment does not improve passive knee joint position sense in healthy adults.

We determined the effects of wearing an above-knee compression garment (CG) on knee joint position sense. Healthy young adults (n = 24, age = 27.46 ± 4.65 years) performed a passive knee position-matching task on an isokinetic dynamometer with each leg separately. We determined the magnitude of compression by measuring anatomical thigh cross sectional area (CSA) in standing using magnetic resonance imaging. Wearing the CG compressed CSA by 2% (t = 2.91, p = 0.010, Cohen's d = 0.68). Repeated measures ANOVA (rANOVA) with three repetition factors (condition: CG, no CG; leg: right dominant, left non-dominant; and target angles: 30°, 45°, 60°) revealed an effect of angles (p < 0.001), where the matching of knee joint position was more accurate at 60° compared to 30° and 45° (p < 0.001). However, CG did not reduce passive joint position sense errors. In fact, joint position error was less without CG (p = 0.014). In conclusion, while CG does compress the thigh it does not afford the purported benefits for proprioception as measured by a target-matching task in the present study

The influence of vancomycin on renal functions, the predictors and associated factors for nephrotoxicity.

BackgroundVancomycin has been widely used in the last six decades to treat methicillin-resistant S. aureus (MRSA) and other resistant gram-positive infections. The risk of vancomycin toxicity increases with the utilization of higher doses while treating the resistant form of bacterial infections. Nephrotoxicity is one of the major complications reported to be a hinderance in the prognosis of vancomycin therapy.ObjectivesThis hospital-based study aimed to highlight the influence of vancomycin on renal function with special emphasis on identifying the predictors and augmenting factors for nephrotoxicity.MethodologyA cross-sectional, unicentric, hospital-based study was conducted at King Fahad Specialist Hospital (KFSH) in Qassim region in Saudi Arabia (KSA). It included 319 hospitalized patients who received vancomycin at intermittent doses (15 to 30 mg/kg IV per day) based on the diseased state. Data regarding vancomycin dose, frequency, duration and data of renal function tests and type of admission were analysed to evaluate their influence on the renal function using parameters such as blood urea, serum creatinine levels and creatinine clearance. One-way ANOVA and Spearman correlation test were used in the analysis of data.ResultsBoth male and female patients treated with vancomycin had significantly (pConclusionData suggested that vancomycin treatment reduced the renal function in patients and indicated its association with several predictors and confounding factors. The findings of the study might assist in identifying the patients under risk from the vancomycin-induced nephrotoxicity and in designing the preventive strategies to reduce such complications

Correlation summary between the variables and renal functions after treatment with vancomycin.

Correlation summary between the variables and renal functions after treatment with vancomycin.</p

Effect of vancomycin on the renal functions according to dose, frequency and duration of treatment.

Effect of vancomycin on the renal functions according to dose, frequency and duration of treatment.</p

Synthesis and spectral characterization of some heterocyclic nitrogen compounds

Quinazolines and pyrimidines are most important class of compounds and have received much attention from both synthetic and medicinal chemists, because of the diverse range of their pharmacological properties. Owing to their versatile chemotherapeutic importance, a number of quinazolin-2,4-dione derivatives were synthesized using appropriate synthetic routes and characterized by IR, 1H NMR, MS, and elemental analysis

Effect of vancomycin on renal function in different types of patients’ admission and site of infections.

Effect of vancomycin on renal function in different types of patients’ admission and site of infections.</p