S-wave eta'-proton FSI; phenomenological analysis of near-threshold production of pi0, eta, and eta' mesons in proton-proton collisions

We describe a novel technique for comparing total cross sections for the reactions pp --> pp pi(0), pp --> pp eta, and pp --> pp eta' close to threshold. The initial and final state proton-proton interactions are factored out of the total cross section, and the dependence of this reduced cross section on the volume of phase space is discussed. Different models of the proton-proton interaction are compared. We argue that the scattering length of the S-wave eta'-proton interaction is of the order of 0.1 fm.Comment: 10 pages, 5 figure

Energy Dependence of the Near-Threshold Total Cross-Section for the pp --> pp eta' Reaction

Total cross sections for the pp --> pp eta' reaction have been measured in the excess energy range from Q = 1.53 MeV to Q = 23.64 MeV. The experiment has been performed at the internal installation COSY-11 using a stochastically cooled proton beam of the COoler SYnchrotron COSY and a hydrogen cluster target. The determined energy dependence of the total cross section weakens the hypothesis of the S-wave repulsive interaction between the eta' meson and the proton. New data agree well with predictions based on the phase-space distribution modified by the proton-proton final-state-interaction (FSI) only.Comment: 12 pages, 1 table, 4 figure

Pseudoscalar Meson Mixing in Effective Field Theory

We show that for any effective field theory of colorless meson fields, the mixing schemes of particle states and decay constants are not only related but also determined exclusively by the kinetic and mass Lagrangian densities. In the general case, these are bilinear in terms of the intrinsic fields and involve non-diagonal kinetic and mass matrices. By applying three consecutive steps this Lagrangian can be reduced into the standard quadratic form in terms of the physical fields. These steps are : (i) the diagonalization of the kinetic matrix, (ii) rescaling of the fields, and (iii) the diagonalization of the mass matrix. In case, where the dimensions of the non-diagonal kinetic and mass sub-matrices are respectively, $k\times k$ and $n\times n$, this procedure leads to mixing schemes which involve $[k(k-1)/2] + [n(n-1)/2]$ angles and $k$ field rescaling parameters. This observation holds true irrespective with the type of particle interactions presumed. The commonly used mixing schemes, correspond to a proper choice of the kinetic and mass matrices, and are derived as special cases. In particular, $\eta$-$\eta '$ mixing, requires one angle, if and only if, the kinetic term with the intrinsic fields has a quadratic form.Comment: REVTeX, 6 page

Strangeness production in proton-proton and proton-nucleus collisions

In these lectures we discuss the investigation of the strange meson production in proton-proton ($pp$) and in proton-nucleus ($pA$) reactions within an effective Lagrangian model. The kaon production proceeds mainly via the excitations of $N^*$(1650), $N^*$(1710), and $N^*$(1720) resonant intermediate nucleonic states, in the collision of two initial state nucleons. Therefore, the strangeness production is expected to provide information about the resonances lying at higher excitation energies. For beam energies very close to the kaon production threshold the hyperon-proton final state interaction effects are quite important. Thus, these studies provide a check on the models of hyperon-nucleon interactions. The in-medium production of kaons show strong sensitivity to the self energies of the intermediate mesons.Comment: 16 pages, 9 figures, Talk presented in the workshop on Hadron Physics, Puri, India, March 7-17,200

pp→pK+Λpp \to pK^{+}\Lambda reaction in an effective Lagrangian model

We investigate the $pp \to pK^{+}\Lambda$ reaction within an effective Lagrangian model where the contributions to the amplitudes are taken into account within the tree level. The initial interaction between the two nucleons is modeled by the exchange of $\pi$, $\rho$, $\omega$ and $\sigma$ mesons and the $\Lambda K^{+}$ production proceeds via the excitation of the $N^*$(1650), $N^*$(1710), $N^*$(1720) baryonic resonances. The parameters of the model at the nucleon-nucleon-meson vertices are determined by fitting the elastic nucleon-nucleon scattering with an effective interaction based on the exchange of these four mesons, while those at the resonance vertices are calculated from the known decay widths of the resonances as well as the vector meson dominance model. Available experimental data is described well by this approach. The one-pion-exchange diagram dominates the production process at both higher and lower beam energies. The $\rho$ and $\omega$ meson exchanges make negligible contributions. However, the $\sigma$-exchange processes contribute substantially to the total cross sections at lower beam energies. The excitation of the $N^*$(1710) and $N^*$(1650) resonances dominate this reaction at beam momenta above and below 3 GeV/c respectively. The interference among the amplitudes of various resonance excitation processes is significant. For beam energies very close to the $K^{+}$ production threshold the hyperon-proton final state interaction effects are quite important. The data is selective about the model used to describe the low energy scattering of the two final state baryons.Comment: Revised version, to appear in Phys. Rev.

Biomarker Report from the Phase II Lamotrigine Trial in Secondary Progressive MS - Neurofilament as a Surrogate of Disease Progression

This work was supported by National MS Society (USA) under the Promise 2010 initiative and the MS Society of Great Britain and Northern Ireland as part of exploratory analysis for the UK MS Clinical Trial Network. VL is supported by Italian Minister of Health grant for young researcher 2008

Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a debilitating adverse effect of cancer treatment. Current understanding of the mechanisms underpinning CIPN is limited and there are no effective treatment strategies. In this study, we treated male C57BL/6J mice with 4 cycles of either Paclitaxel (PTX) or Oxaliplatin (OXA) over a week and tested pain hypersensitivity and changes in peripheral immune responses and neuroinflammation on days 7 and 13 post 1st injection. We found that both PTX and OXA caused significant mechanical allodynia. In the periphery, PTX and OXA significantly increased circulating CD4+ and CD8+ T-cell populations. OXA caused a significant increase in the percentage of interleukin-4+ lymphocytes in the spleen and significant down-regulation of regulatory T (T-reg) cells in the inguinal lymph nodes. However, conditional depletion of T-reg cells in OXA-treated transgenic DEREG mice had no additional effect on pain sensitivity. Furthermore, there was no leukocyte infiltration into the nervous system of OXA- or PTX-treated mice. In the peripheral nervous system, PTX induced expression of the neuronal injury marker activating transcription factor-3 in IB4+ and NF200+ sensory neurons as well as an increase in the chemokines CCL2 and CCL3 in the lumbar dorsal root ganglion. In the central nervous system, PTX induced significant astrocyte activation in the spinal cord dorsal horn, and both PTX and OXA caused reduction of P2ry12+ homeostatic microglia, with no measurable changes in IBA-1+ microglia/macrophages in the dorsal and ventral horns. We also found that PTX induced up-regulation of several inflammatory cytokines and chemokines (TNF-α, IFN-γ, CCL11, CCL4, CCL3, IL-12p70 and GM-CSF) in the spinal cord. Overall, these findings suggest that PTX and OXA cause distinct pathological changes in the periphery and nervous system, which may contribute to chemotherapy-induced neuropathic pain

Chitayat-Hall and Schaaf-Yang syndromes: a common aetiology: expanding the phenotype of MAGEL2-related disorders

Chitayat-Hall syndrome, initially described in 1990, is a rare condition characterised by distal arthrogryposis, intellectual disability, dysmorphic features and hypopituitarism, in particular growth hormone deficiency. The genetic aetiology has not been identified.Background Chitayat-Hall syndrome, initially described in 1990, is a rare condition characterised by distal arthrogryposis, intellectual disability, dysmorphic features and hypopituitarism, in particular growth hormone deficiency. The genetic aetiology has not been identified. Methods and results We identified three unrelated families with a total of six affected patients with the clinical manifestations of Chitayat-Hall syndrome. Through whole exome or whole genome sequencing, pathogenic variants in the MAGEL2 gene were identified in all affected patients. All disease-causing sequence variants detected are predicted to result in a truncated protein, including one complex variant that comprised a deletion and inversion. Conclusions Chitayat-Hall syndrome is caused by pathogenic variants in MAGEL2 and shares a common aetiology with the recently described Schaaf-Yang syndrome. The phenotype of MAGEL2-related disorders is expanded to include growth hormone deficiency as an important and treatable complicationhe McLaughlin Centre, University of Toronto, Toronto, Canada, and Fondation Jeanne et Jean- Louis Lévesque (JLM). The Centre for Genetic Medicine, The Hospital for Sick Children, Toronto, Canada. FDL has a fellowship funded by FCT - Fundação para a Ciência e a Tecnologia (SFRH/BD/84650/2010)info:eu-repo/semantics/publishedVersio

Evolutionary explanations in medical and health profession courses: are you answering your students' "why" questions?

BACKGROUND: Medical and pre-professional health students ask questions about human health that can be answered in two ways, by giving proximate and evolutionary explanations. Proximate explanations, most common in textbooks and classes, describe the immediate scientifically known biological mechanisms of anatomical characteristics or physiological processes. These explanations are necessary but insufficient. They can be complemented with evolutionary explanations that describe the evolutionary processes and principles that have resulted in human biology we study today. The main goal of the science of Darwinian Medicine is to investigate human disease, disorders, and medical complications from an evolutionary perspective. DISCUSSION: This paper contrasts the differences between these two types of explanations by describing principles of natural selection that underlie medical questions. Thus, why is human birth complicated? Why does sickle cell anemia exist? Why do we show symptoms like fever, diarrhea, and coughing when we have infection? Why do we suffer from ubiquitous age-related diseases like arteriosclerosis, Alzheimer's and others? Why are chronic diseases like type II diabetes and obesity so prevalent in modern society? Why hasn't natural selection eliminated the genes that cause common genetic diseases like hemochromatosis, cystic fibrosis, Tay sachs, PKU and others? SUMMARY: In giving students evolutionary explanations professors should underscore principles of natural selection, since these can be generalized for the analysis of many medical questions. From a research perspective, natural selection seems central to leading hypotheses of obesity and type II diabetes and might very well explain the occurrence of certain common genetic diseases like cystic fibrosis, hemochromatosis, Tay sachs, Fragile X syndrome, G6PD and others because of their compensating advantages. Furthermore, armed with evolutionary explanations, health care professionals can bring practical benefits to patients by treating their symptoms of infection more specifically and judiciously. They might also help curtail the evolutionary arms race between pathogens and antibiotic defenses