10 research outputs found
Antithrombotic/anticoagulant and anticancer activities of selected medicinal plants from South Africa
Get PDFNine plants available in the Eastern Cape Province of South Africa were tested for antithrombotic and/or anticoagulant activity. Organic (methanol) and aqueous (distilled water) extractions were performed onthe various plant parts. The thrombin assay and clotting time assays (thrombin-induced and CaCl2-induced) were utilised. Several extracts displayed activity, but in most cases this was due to the presence of tannins. Only the aqueous extracts displayed activity after tannin removal. The Sutherlandia frutescens leaf extract displayed antithrombotic activity, with an IC50 value of 2.17 mg/ml. Gloriosa superba and Zantedeschia aethiopica leaf extracts displayed anticoagulant properties by inhibiting thrombin-induced clotting, with IC50 values of 2.97 and 3.05 mg/ml, respectively. The Leonotisleonurus root extract was found to decrease the CaCl2-induced clotting time by 50% at 8.88 mg/ml. A decrease in this value accompanied by a decrease in fibrin formation was preferable for the CaCl2-induced assay, since decreased fibrin formation may have a role in the prevention of cancer metastasis. As tannins were found to contribute minimally to the anticoagulant effect of L. leonurus, the cytotoxicity potential of the extracts of this species against five cell lines was determined. Only the organic extract yielded significant cytotoxity
Commercial Law 2A: ACL 211E & LCM 211
No full textCommercial Law 2A : ACL 211E & LCM 211, July/August Supplementary Paper 201
Nanoformulation of Leonotis leonurus to improve its bioavailability as a potential antidiabetic drug
No full textEffects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL/6 mice
No full textFunctional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare
No full textEnhanced biosynthesis of bioactive abietane diterpenes by overexpressing AtDXS or AtDXR genes in Salvia sclarea hairy roots
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Chemistry and biochemistry of Terpenoids from Curcumaand related species
No full textSeveral curcuminoids have been identified from rhizome of the common spice Curcuma longa (Zingaberaceae) and related plant species. Curcuminoids are known to display several pharmacological properties summed up in numerous papers and reviews. In addition to curcuminoids, more than 250 mono-, sesqui- di-, and triterpenoids have been identified from curcuma species. These lipophilic compounds have better absorption than curcuminoids and also exhibit a wide spectrum of pharmacological properties. Little attention has been paid to these lipophilic compounds, which may be as physiologically active, if not more, as curcuminoids. This review focuses on Curcuma terpenoids and their physiological properties
