La organización para la seguridad y la cooperación en Europa y los conflictos territoriales en Europa

[Resumo] A firma do Acta Final da Conferencia sobre a Seguridade e a Cooperación en Europa (Helsinki 1975) abriu o proceso de construción da seguridade e a cooperación en Europa. Desde entón producíronse profundos cambios no escenario europeo xerando tensións e conflitos territoriais. Este traballo de investigación aborda o papel que en devanditos conflitos desempeña a CSCE/OSCE. Para iso, examínanse na primeira parte do mesmo as bases políticas e xurídicas do funcionamento da CSCE/OSCE como instrumento da seguridade europea. E, nunha segunda parte, as principais cuestións políticas e xurídicas derivadas da participación da CSCE/OSCE na solución pacífica dos conflitos territoriais en Europa, examinándose, en particular, as misións sobre o terreo da CSCE/OSCE.[Resumen]La firma del Acta Final de la Conferencia sobre la Seguridad y la Cooperación en Europa (Helsinki 1975) abrió el proceso de construcción de la seguridad y la cooperación en Europa. Desde entonces se han producido profundos cambios en el escenario europeo generando tensiones y conflictos territoriales. Este trabajo de investigación aborda el papel que en dichos conflictos desempeña la CSCE/OSCE. Para ello, se examinan en la primera parte del mismo las bases políticas y jurídicas del funcionamiento de la CSCE/OSCE como instrumento de la seguridad europea. Y, en una segunda parte, las principales cuestiones políticas y jurídicas derivadas de la participación de la CSCE/OSCE en la solución pacífica de los conflictos territoriales en Europa, examinándose, en particular, las misiones sobre el terreno de la CSCE/OSCE.[Abstract] The signing of the Final Act of the Conference on Security and Cooperation in Europe (Helsinki 1975) started the process of building security and cooperation in Europe. Since then there have been profound changes in the European scenario generating tensions and territorial disputes. This research deals with the role CSCE/OSCE has had in these conflicts by examining in the first chapter political and legal foundations for the functioning of the CSCE/OSCE as an instrument of European security. The second chapter discusses the main political and legal issues arising from the participation of the CSCE/OSCE in the peaceful settlement of territorial conflicts in Europe, examining in particular the field missions of the CSCE/OSCE

El derecho de autodeterminación a la luz de los conflictos territoriales en Europa: el caso de Nagorno Karabaj

[Resumen] La historia moderna de Europa nos enseña que el ejercicio del derecho de auto- determinación de los pueblos ha dado pie, en la mayoría de los casos, al comienzo de conflictos territoriales. Entre estas disputas, por su complejidad y particularidad, se dis- tingue el caso de Nagorno Karabaj. Con la finalidad de tener una buena comprensión de esta cuestión, analizaremos el conflicto tanto desde punto de vista histórico y político, como jurídico a la luz del derecho de autodeterminación de los pueblos.[Abstract] The modern history of Europe shows us that the execution of the right of self- determination has led to the beginning of territorial conflicts. Because of its complexi- ty and particularity, the case of Nagorno Karabakh is distinguished among these dis- putes. In order to have a clear understanding of this issue, we will analyze the conflict from historical, political and legal points of view as well as in the light of people’s right to self determination

Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8(+) T-cell proliferation and survival

The authors thank Dr Esteban Celis and Dr Rhea-Beth Markowitz for reviewing the manuscript and for their valuable suggestions and also thank Dr Lei Huang for his suggestions.Peer reviewedPublisher PD

Research of the overall chemical and amino acid composition of meat from young animals of new sheep genotypes

The paper presents the results of the investigation of the overall chemical composition (mass fraction of moisture, fat, protein and ash) and the amino acid composition of mutton from the experimental animals of new genotypes: Sovetsky Merino x Dzhalginsky Merino and Sovetsky Merino x Stavropolsky breed. As a control, meat of purebred Sovetsky Merino was studied. The experimental and control rams were slaughtered at the age of 8 months by the conventional technology. Meat samples for laboratory examination were taken a day after slaughter. The results of the analysis of the overall chemical composition showed that lamb meat of new genotypes had lower moisture content and higher content of fat and protein compared to the control. Analysis of the amino acid composition of meat proteins of genotypes Sovetsky Merino x Dzhalginsky Merino and Sovetsky Merino x Stavropolsky breed revealed lower content of essential amino acids compared to the control. Comparison of amino acid scores showed that the amino acid composition of meat proteins from the experimental animals was limited by valine and lysine, respectively. It was concluded by the results of the investigations of the amino acid composition of proteins that the biological full value of proteins of mutton from new genotypes was 22.9% and 30.3% lower than that of the control

Old-School Chemotherapy in Immunotherapeutic Combination in Cancer, A Low-cost Drug Repurposed

©2016 American Association for Cancer Research.Peer reviewedPostprin

Antigen-Specific Antitumor Responses Induced by OX40 Agonist Are Enhanced by the IDO Inhibitor Indoximod

Published article becomes freely available online after 12 monthsPeer reviewedPostprin

Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy

Copyright ©2017, American Association for Cancer Research.Peer reviewedPostprin

Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition

Financial support: This work was supported by Georgia Cancer Center, Augusta University (S. Khleif). Acknowledgements The authors would like to thank Dr Frank Ward for his advice on experimental design.Peer reviewedPostprin

The history of ethical regulation of biomedical research in the CIS member states

The history of development the ethical and legislative tools for regulation the biomedical research in the states-members of Commonwealth of Independent States (CIS) in the frame of the close collaboration the Forum for Ethics Committees in the Commonwealth of Independent States (FECCIS) and Inter-Parliamentary Assembly CIS (IPA CIS) is demonstrated in this article. The collaboration between FECCIS and IPA CIS stands on the unique experience of IPA CIS in the building of the new, humanistic legislation in the field of health care and on the initiatives of FECCIS to create a single legal space inside and outside of the CIS region. The necessity to promote the dignity, rights, and well-being of human participants in health research was the real reason for creation the Model Law «On the Protection of Human Rights and Dignity in Biomedical Research in the CIS». The process of the law creation, its direction, structure, compliance with international ethical standards and implementation in the local legislation of CIS states are analysed by the main authors of Model Law «On the Protection of Human Rights and Dignity in Biomedical Research in the CIS» and presented in this review

Anti-PD-1 antibody significantly increases therapeutic efficacy of Listeria monocytogenes (Lm)-LLO immunotherapy

This work was supported by the Intramural Research Program of the Center for Cancer Research, NCI, NIH, Georgia Regents University Cancer Center (GRUCC) and Advaxis Inc. RAE is supported by a Fellowship Grant from King Hussein Institute for Biotechnology and Cancer (KHIBC, Jordan).Peer reviewedPublisher PD