関東構造盆地中・西部における第四紀地質

本研究は関東地方中央部で沈降し，周縁部で隆起したという関東構造盆地内に厚く堆積した第三紀末鮮新世から第四紀にかけての地質層序と地形発達史を総合的に解明した研究である。研究地域には鮮新世後期から更新世後期の地層が分布している。それらの下位層は主として海成層，上部層は陸成層から成る。下位層は矢颪層，飯能層，仏子層に新たに区分し，これらが多摩丘陵に分布する大矢部層，平山層，善光寺層にそれぞれ追跡され，年代的に対比されることを可能とした。また，これらの海成層の分布が現在の丘陵地より西側まで分布していることから，陸水と海水の境界は関東山地前縁の山稜部にあったと言える。このことは，国際的年代対比の可能なスケールとして，多摩丘陵の層序と房総地域の対比を可能としたことになる。地質年代的には多摩火山灰層下限の年代が黒雲母密集帯のフィッシヨン・トラック年代測定から55±7万年より古く，房総半島笠森層上部に対比される。八王子黒雲母軽石層は38±7万年と測定され，武蔵野火山灰層と下末吉火山灰層境界部の年代は東京火山灰層（4.9±0.5万年）の存在が無くても，年代は推定できる。　気候変化に起因して，海水面が上昇すると広大な海成層が堆積し，海水面が低下すると海成層は陸化し，海岸段丘が形成されることに着目し，関東構造盆地内に分布する層厚を異にした段丘礫層の解明を行った。即ち，更新世末期の下末吉海進と呼ばれる高海面期に形成された広大な海生貝化石を産出する浅海域が海水面低下に伴って陸化し，海岸段丘が形成される。さらに，関東構造盆地では海水面低下と共に延長河川が発達し，世界的に共通した気候変化に連動した地形的オシレイションが礫岩の供給地との距離的関連で，段丘形成が複雑な様式を示している。例えば，丘陵地の段丘堆積物は下末吉海進以前の高海面期に，また台地の段丘堆積物は高海面期以降の海面低下に連動して形成された。さらに，下末吉海進期の高海面期に堆積した多摩川流域の堆積物は，その後の海退に伴う河川などの浸食により，浸食し切れないか，薄いかで，上流部の青梅市から瑞穂町で厚く堆積していることが明示される。また火山灰層の分類，層序的位置付がこれら段丘面の広域的な対比と編年が可能であり，木曽御岳火山第1軽石層が下末吉火山灰層申部に追跡され，鹿児島姶良カルデラからの姶良火山灰層が立川火山灰層に狭在しているなど，広域的な火山灰による年代の設定を行った。 The Quaternary System of Kanto Region is composed of marine and terrestrial deposits and the Kanto Volcanic Ash. The marine deposits have been mainly studied in Chiba Prefecture. The terrestrial deposits and airborne volcanic ash have been studied in the whole Kanto Region. ...Thesis (Ph. D. in Science)--University of Tsukuba, (B), no. 1505, 1999.3.25Titlepage,Contents -- Figures,Tables,Plates -- Abstract -- 1. Introduction -- 2. Outlines of the geomorphology and geology -- 3. Stratigraphy in the Kanto Tectonic Basin -- 4. Division of Volcanic Ashes -- 5. Division of terraces -- 6. Transition of the Environment -- 7. Deformation of Topography -- 8. Conclusion -- Acknowledgements -- References -- Figures -- Tables -- Plate

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers.

Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic dysregulation outside the promoter region may be more closely associated with transcriptional changes. Here we examine DNA methylation, chromatin marks, and transcriptional alterations to define the relationship between transcriptional modulation and spatial changes in chromatin structure. Using human papillomavirus-related oropharyngeal carcinoma as a model, we show aberrant enrichment of repressive H3K9me3 at the transcriptional start site (TSS) with methylation-associated, tumor-specific gene silencing. Further analysis identifies a hypermethylated subtype which shows a functional convergence on MYC targets and association with CREBBP/EP300 mutation. The tumor-specific shift to transcriptional repression associated with DNA methylation at TSSs was confirmed in multiple tumor types. Our data may show a common underlying epigenetic dysregulation in cancer associated with broad enrichment of repressive chromatin marks and aberrant DNA hypermethylation at TSSs in combination with MYC network activation

Degeneration of amyloid-ß fibrils caused by exposure to low-temperature atmospheric-pressure plasma in aqueous solution

Low-temperature atmospheric-pressure plasma was applied to degenerate amyloid-ß (Aß) fibrils, which are a major component of neuritic plaque associated with Alzheimer\u27s disease (AD). We showed that an Aß fibril exposed to a low-frequency (LF) plasma jet in aqueous solution retained its morphology, molecular weight, and cytotoxicity, but, intriguingly, decreased in protease resistance and ß-sheet content. These results suggested that an LF plasma jet could be utilized for the treatment of AD to eliminate neuritic plaque by accelerating the proteolysis of Aß fibrils

Hypertension resistant to antihypertensive agents commonly occurs with the progression of diabetic nephropathy in Japanese patients with type 2 diabetes mellitus: a prospective observational study

BACKGROUND: We investigated 1) the frequency of hypertension in patients with type 2 diabetes graded by the new classification of chronic kidney disease (CKD) reported by the Kidney Disease: Improving Global Outcomes (KDIGO) and 2) the number of antihypertensive agents needed to achieve treatment goals using a prospective observational study. METHODS: A population of 2018 patients with type 2 diabetes mellitus was recruited for the study. The CKD stage was classified according to the eGFR and the urinary albumin excretion levels. RESULTS: Hypertension was found in 1420 (70%) of the patients, and the proportion of subjects showing a blood pressure < 130/80 mmHg was 31% at the baseline. Although the mean blood pressure was approximately 130/75 mmHg, the rate of patients with a blood pressure of < 130/80 mmHg became limited to 41-50% during the observation period. The number of antihypertensive agents required for treatment was significantly higher at the endpoint (2.0 ± 1.3) than at the baseline (1.6 ± 1.2). Furthermore, it increased with the progression of the CKD stage at both the baseline and the endpoint of the observation. However, the frequency of subjects who did not achieve the blood pressure target was found to increase in the group demonstrating the later stage of CKD. CONCLUSIONS: Hypertension resistant to antihypertensive agents was common in the patients with type 2 diabetes mellitus and increased with the progression of CKD. Although powerful combination therapy using antihypertensive agents is considered necessary for the strict control of blood pressure, this became difficult in individuals who were in advanced stages as graded based on the eGFR and the urinary albumin excretion levels

Clinical disorders affecting mesopic vision

Vision in the mesopic range is affected by a number of inherited and acquired clinical disorders. We review these conditions and summarize the historical background, describing the clinical characteristics alongside the genetic basis and molecular biological mechanisms giving rise to rod and cone dysfunction relevant to twilight vision. The current diagnostic gold standards for each disease are discussed and curative and symptomatic treatment strategies are summarized

A List of Papers and Data Book by ACOS 600 Users Published in Fiscal Year 1979

1980-03-24departmental bulletin pape

DISTRIBUTION OF ATMOSPHERIC SOURCES AROUND JAPAN FOR A FEW DAYS IN SUMMER 1969

1971-03-30departmental bulletin pape