Damped free motion of rocking specimens in non-linear time history response analysis

In dynamic soil-structure interaction (SSI), the structure such as a building, the sway of the foundation and the rocking on ground, during an earthquake, are usually analyzed without coupled system. In this paper, assuming a restoring force - displacement characteristics for rocking, while the structure and the sway on the assumption are rigid body, non - linear time history response analysis of rocking in the damped free motion of are carried out, with the comparison of the experimental values

Non-cross-linking gold nanoparticle aggregation as a detection method for single-base substitutions

Aggregation of DNA-modified gold nanoparticles in a non-cross-linking configuration has extraordinary selectivity against terminal mismatch of the surface-bound duplex. In this paper, we demonstrate the utility of this selectivity for detection of single-base substitutions. The samples were prepared through standard protocols: DNA extraction, PCR amplification and single-base primer extension. Oligonucleotide-modified nanoparticles correctly responded to the unpurified products from the primer extension: aggregation for the full match and dispersion for all the mismatches. Applicability of this method to genomic DNA was tested with five human tumor cell lines, and verified by conventional technologies: mass spectrometry and direct sequencing. Unlike the existing methods for single-base substitution analysis, this method does not need specialized equipments, and opens up a new possibility of point-of-care diagnosis for single-nucleotide polymorphisms

Predominant periods of multi-degree-of-freedomsystem analysis and dynamic soil-structure interaction for building structures

Coupled problems of the multi-degree-of-freedom-system (MDOF) or SoilStructure Interaction (SSI) are usually translated to a series of the single-degree-of-freedom (SDOF) equations. In this paper, the predominant periods of MDOF analysis are analyzed without SDOF and the dynamic amplification factors for a sample data of a model building are shown. The analysis method is the assumption that, as well as SDOF analysis, the MDOF analysis is applied to the predominant periods by inelastic analysis. That can give the dynamic amplification factors of the MDOF. At the results, it is cleared that the predominant period of the MDOF is close to be the period by the eigenvalues and in the short period or in the high level modes, the dynamic amplification factors are high which should not be neglected. Moreover, soil-structure interaction with SDOF are also analyzed by elastic analysis for the model building. Some effects to the building structure model by the rocking on the ground are discussed in the sway-rocking models