37 research outputs found

    Percutaneous Absorption Of Betamethasone 17-Benzoate Measured By Radioimmunoassay

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    Percutaneous absorption was studied in patients following topical application of betamethasone 17-benzoate cream and gel with occlusion by means of a sensitive and specific radioimmunoassay method. Concentrations of betamethasone 17-benzoate in plasma were between 0.3 and 5 ng/ml, indicating approximately 0.05 to 0.3% of the steroid applied to the skin was detected in plasma. Plasma betamethasone 17-benzoate levels increased in proportion to the amount of the steroid applied to the skin. High correlation between plasma betamethasone 17-benzoate levels and percent inhibition of plasma cortisol was also observed. Approximately 3 ng/ml levels of betamethasone 17-benzoate in plasma induced 90% inhibition of plasma cortisol. The data suggest that betamethasone 17-benzoate in gel base was more readily absorbed than in cream base

    A study on false alarm cancellation for spectrum usage measurements

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    Abstract Two-layer smart spectrum access (SSA) consists of spectrum sharing based on dynamic spectrum access (DSA: first layer) and spectrum awareness system (SAS: second layer). A main role of SAS is providing useful statistical information in terms of spectrum usage by long term, wide-band and wide-area measurements. In this paper, we focus on signal area (SA) estimation which is a core signal processing in SAS to understand the spectrum usage. Specifically, SA estimation is used as post processing for energy detector outputs. It has been shown that Simple-SA (S-SA) estimation can enhance the spectrum usage measurement performance, but it inherently increases false alarms. For this issue, efficient false alarm cancellation technique, L-shaped false alarm cancellation (L-FC), is proposed in this paper. Numerical evaluations show that the proposed method can achieve proper detection performance while the computational cost is small compared to other methods
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