The MAGIC Telescope and the Observation of Gamma Ray Bursts

The MAGIC Telescope, now taking data with an energy threshold well below 100 GeV, will soon be able to take full advantage of the fast slewing capability of its altazimuthal mount. Exploiting the link with the GCN network, the MAGIC Telescope could be one of the first ground-based experiments able to see the prompt emission of Gamma Ray Bursts in the few tens of GeV region.Comment: 4 pages, 1 figure (-> 3 subfigures), class file (cimento.cls) included. To appear in: "Gamma-Ray Bursts in the Afterglow Era: 4rd Workshop", Rome 200

GRB 050713A: High Energy Observations of the GRB Prompt and Afterglow Emission

Swift discovered GRB 050713A and slewed promptly to begin observing with its narrow field instruments 72.6 seconds after the burst onset, while the prompt gamma-ray emission was still detectable in the BAT. Simultaneous emission from two flares is detected in the BAT and XRT. This burst marks just the second time that the BAT and XRT have simultaneously detected emission from a burst and the first time that both instruments have produced a well sampled, simultaneous dataset covering multiple X-ray flares. The temporal rise and decay parameters of the flares are consistent with the internal shock mechanism. In addition to the Swift coverage of GRB 050713A, we report on the Konus-Wind (K-W) detection of the prompt emission in the energy range 18-1150 keV, an upper limiting GeV measurement of the prompt emission made by the MAGIC imaging atmospheric Cherenkov telescope and XMM-Newton observations of the afterglow. Simultaneous observation between Swift XRT and XMM-Newton produce consistent results, showing a break in the lightcurve at T+~15ks. Together, these four observatories provide unusually broad spectral coverage of the prompt emission and detailed X-ray follow-up of the afterglow for two weeks after the burst trigger. Simultaneous spectral fits of K-W with BAT and BAT with XRT data indicate that an absorbed broken powerlaw is often a better fit to GRB flares than a simple absorbed powerlaw. These spectral results together with the rapid temporal rise and decay of the flares suggest that flares are produced in internal shocks due to late time central engine activity.Comment: 22 pages, 6 tables, 10 figures; Submitted to the Astrophysical Journa

Structural comparison of the free and DNA-bound forms of the purine repressor DNA-binding domain

AbstractBackground: The purine repressor (PurR) regulates genes that encode enzymes for purine biosynthesis. PurR has a two domain structure with an N-terminal DNA-binding domain (DBD) and a C-terminal corepressor-binding domain (CBD). The three-dimensional structure of a ternary complex of PurR bound to both corepressor and a specific DNA sequence has recently been determined by X-ray crystallography.Results We have determined the solution structure of the PurR DBD by NMR. It contains three helices, with the first and second helices forming a helix-turn-helix motif. The tertiary structure of the three helices is very similar to that of the corresponding region in the ternary complex. The structure of the hinge helical region, however, which makes specific base contacts in the minor groove of DNA, is disordered in the DNA-free form.Conclusion The stable formation of PurR hinge helices requires PurR dimerization, which brings the hinge regions proximal to each other. The dimerization of the hinge helices is likely to be controled by the CBD dimerization interface, but is induced by specific-DNA binding

Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism

Background. The effect of cinacalcet on the structural pattern of hyperplastic parathyroid glands was evaluated, using high-resolution colour Doppler (CD) sonography, in haemodialysis patients with severe, inadequately controlled, secondary hyperparathyroidism (sHPT)

Review of recent experimental progresses in Foundations of Quantum Mechanics and Quantum Information obtained in Parametric Down Conversion Experiments at IENGF

We review some recent experimental progresses concerning Foundations of Quantum Mechanics and Quantum Information obtained in Quantum Optics Laboratory "Carlo Novero" at IENGF. More in details, after a short presentation of our polarization entangled photons source (based on precise superposition of two Type I PDC emission) and of the results obtained with it, we describe an innovative double slit experiment where two degenerate photons produced by PDC are sent each to a specific slit. Beyond representing an interesting example of relation between visibility of interference and "welcher weg" knowledge, this configuration has been suggested for testing de Broglie-Bohm theory against Standard Quantum Mechanics. Our results perfectly fit SQM results, but disagree with dBB predictions. Then, we discuss a recent experiment addressed to clarify the issue of which wave-particle observables are really to be considered when discussing wave particle duality. This experiments realises the Agarwal et al. theoretical proposal, overcoming limitations of a former experiment. Finally, we hint to the realization of a high-intensity high-spectral-selected PDC source to be used for quantum information studies

STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone

Calcium signaling plays a central role in bone development and homeostasis. Store operated calcium entry (SOCE) is an important calcium influx pathway mediated by calcium release activated calcium (CRAC) channels in the plasma membrane. Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum calcium sensing protein important for SOCE. We generated a mouse model expressing the STIM1 R304W mutation, causing Stormorken syndrome in humans. Stim1R304W/R304W mice showed perinatal lethality, and the only three animals that survived into adulthood presented with reduced growth, low body weight, and thoracic kyphosis. Radiographs revealed a reduced number of ribs in the Stim1R304W/R304W mice. Microcomputed tomography data revealed decreased cortical bone thickness and increased trabecular bone volume fraction in Stim1R304W/R304W mice, which had thinner and more compact bone compared to wild type mice. The Stim1R304W/+ mice showed an intermediate phenotype. Histological analyses showed that the Stim1R304W/R304W mice had abnormal bone architecture, with markedly increased number of trabeculae and reduced bone marrow cavity. Homozygous mice showed STIM1 positive osteocytes and osteoblasts. These findings highlight the critical role of the gain-of-function (GoF) STIM1 R304W protein in skeletal development and homeostasis in mice. Furthermore, the novel feature of bilateral subgingival hair growth on the lower incisors in the Stim1R304W/R304W mice and 25 % of the heterozygous mice indicate that the GoF STIM1 R304W protein also induces an abnormal epithelial cell fate