10 research outputs found
Employment Trends in Textiles and Apparel, 1973-2005
[Excerpt] The article “examines employment trends in the textile and apparel industries, reviewing the likely causes of both the recent historical and projected declines, their varied effects across occupations groups, and the response American producers have developed to adapt to the rapidly changing economic realities”
A complex speciation-richness relationship in a simple neutral model
Speciation is the "elephant in the room" of community ecology. As the
ultimate source of biodiversity, its integration in ecology's theoretical
corpus is necessary to understand community assembly. Yet, speciation is often
completely ignored or stripped of its spatial dimension. Recent approaches
based on network theory have allowed ecologists to effectively model complex
landscapes. In this study, we use this framework to model allopatric and
parapatric speciation in networks of communities and focus on the relationship
between speciation, richness, and the spatial structure of communities. We find
a strong opposition between speciation and local richness, with speciation
being more common in isolated communities and local richness being higher in
more connected communities. Unlike previous models, we also find a transition
to a positive relationship between speciation and local richness when dispersal
is low and the number of communities is small. Also, we use several measures of
centrality to characterize the effect of network structure on diversity. The
degree, the simplest measure of centrality, is found to be the best predictor
of local richness and speciation, although it loses some of its predictive
power as connectivity grows. Our framework shows how a simple neutral model can
be combined with network theory to reveal complex relationships between
speciation, richness, and the spatial organization of populations.Comment: 9 pages, 5 figures, 1 table, 50 reference
Nat Genet
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems.Comment in : Genetic differential calculus. [Nat Genet. 2015]
Comment in : Scaling up phenotyping studies. [Nat Biotechnol. 2015
Employment Trends in Textiles and Apparel, 1973-2005
[Excerpt] The article “examines employment trends in the textile and apparel industries, reviewing the likely causes of both the recent historical and projected declines, their varied effects across occupations groups, and the response American producers have developed to adapt to the rapidly changing economic realities”.emp8tx97.pdf: 596 downloads, before Oct. 1, 2020
Island species lists and island properties
First sheet is an island-species matrix of species presences (0 or 1). Second sheet includes spatial data for each island. Taxonomic nomenclature follows Haines (2011). See associated publication for details on data collection methods and supplemental appendix for additional metadata
Negotiating Difference: Constructing Selves and Others in a Transnational Apparel Manufacturing Firm
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the characterization of relationships between genes and phenotypes. The EUMODIC consortium developed and validated robust methodologies for the broad-based phenotyping of knockouts through a pipeline comprising 20 disease-oriented platforms. We developed new statistical methods for pipeline design and data analysis aimed at detecting reproducible phenotypes with high power. We acquired phenotype data from 449 mutant alleles, representing 320 unique genes, of which half had no previous functional annotation. We captured data from over 27,000 mice, finding that 83% of the mutant lines are phenodeviant, with 65% demonstrating pleiotropy. Surprisingly, we found significant differences in phenotype annotation according to zygosity. New phenotypes were uncovered for many genes with previously unknown function, providing a powerful basis for hypothesis generation and further investigation in diverse systems