Транскраниальная магнитная стимуляция с электроэнцефалографией: методология, экспериментальные и клинические возможности

Combined use of transcranial magnetic stimulation and electroencephalography (TMS-EEG) is a highly informative cutting edge technology which is relevant for fundamental, clinical and  translational research. Unique capabilities of TMS-EEG approach  allow to assess the functional state and connectivity of brain regions  thus opening new prospects for the evaluation of the TMS effects in  non-motor cortical areas. TMS-EEG responses have diagnostic and  prognostic potential for many neurological and mental illnesses.  Simultaneous co-registration of TMS with EEG remains a technically  sophisticated procedure and requires specialized equipment in  conjunction with application of complex data analysis techniques.  This review describes the details of TMS-EEG technique, principles of the experiment design, the shape and the reproducibility of TMS- evoked responses and applications of this promising approach both  in research and in clinics. Комбинированное использование транскраниальной магнитной стимуляции и электроэнцефалографии (ТМС-ЭЭГ) является современным высокоинформативным  экспериментальным подходом, который находит применение как в фундаментальных, так и  в клинических и трансляционных исследованиях. Уникальные возможности ТМС-ЭЭГ  позволяют оценивать функциональное состояние и связность областей мозга, а также  открывают новые перспективы оценки эффектов ТМС недвигательных областей коры.  Маркеры ТМС-ЭЭГ обладают диагностическим и прогностическим потенциалом в отношении  многих неврологических и психических болезней. Регистрация ЭЭГ одновременно с ТМС  остается технически сложной процедурой и требует наличия как специального  оборудования, так и примения сложных методов анализа данных. В настоящем обзоре  описаны технические особенности ТМС-ЭЭГ, принцип построения дизайна исследований, вид и  стабильность ТМС вызванного ответа на ЭЭГ, а также область применения метода ТМС-ЭЭГ

Ultrasound investigation in estimation of vascular invasion and morphological verification of pancreatic tumors

The aim of publication. To present potential of ultrasound investigation (US) in diagnostics of pancreatic tumors (PT).Summary. Morphological verification of PT and estimation of stage of their progression are the basic factors of treatment planning. Traditionally «the gold standard» in detection of tumor and estimation of vascular invasion is computer tomography. In world practice US at PT is used only at the stage of primary diagnostics, as a rule, application at specifying diagnostics stage is limited because the method is operator-dependent and storage of study data is complex. However US can be carried out in various planes and positions of the patient’s body, that in some cases helps to receive additional information. Though morphological verification is the leading factor in assessment of prognosis and treatment approach at oncologic diseases, its necessity and ways of tissue sampling at PT is discussed up to now.Conclusion. Potential of US in morphological verification and assessment of vascular invasion of PT is demonstrated by the clinical case example, that has allowed to carry out radical surgical treatment to the patient

Непрерывный лазер на кристалле пентабората, соактивированного ионами эрбия и иттербия

We report, for the first time to our knowledge, a diode-pumped continuous-wave microchip Er,Yb:YMgB5O10 laser. The purpose of this work was to study the growth technique, spectroscopic properties and continuous-wave laser performance of Er3+,Yb3+:YMgB5O10 novel crystal. Absorption and luminescence spectra as well as kinetics of luminescence decay were studied. Ytterbium-erbium energy transfer efficiency was determined. The output characteristics (output power, slope efficiency, laser wavelength) of Er3+,Yb3+:YMgB5O10 laser were determined.Two intensive absorption bands with peaks centered at 937 nm and 976 nm were observed in the absorption spectra at the wavelength near 1 μm. The maximum value of absorption cross-section was determined to be 1.5·10–20 cm2 at 976 nm for polarization E//Ng . A number of narrow lines were observed in the absorption spectra in the 1425–1575 nm spectral range (transition 4I15/2 → 4I13/2 of erbium ions). The lifetime of the upper laser level 4I13/2 of Er3+ ions was determined to be 390 ± 20 μs. The ytterbium-erbium energy transfer efficiency for YMgB5O10 crystal with 2 at.% of Er3+ and 11 at.% for Yb3+ was close to 84 %. The maximal continuous-wave output power of 0.2 W with slope efficiency of 8 % regarding to absorbed pump power was realized at the wavelength of 1570 nm. With the improvement of cavity parameters the output laser performance of the Er,Yb:YMgB5O10 crystal can be further enhanced.Taking into account high thermal conductivity of ≈ 6.2 W·m–1·K–1, the Er,Yb:YMgB5O10 crystal can be considered as a good gain medium for 1.5 μm lasers for applications in laser rangefinder and LIDAR systems.Впервые сообщается о непрерывном лазере на кристалле Er,Yb:YMgB5O10 с диодной накачкой. Изучены условия синтеза кристаллов, спектры поглощения и люминесценции, кинетики затухания люминесценции. Определена эффективность переноса энергии от ионов иттербия к ионам эрбия. Определены выходные характеристики (выходная мощность, дифференциальный КПД, длина волны генерации) лазера на основе кристалла Er3+,Yb3+:YMgB5O10.В спектрах поглощения в области 1 мкм наблюдаются две интенсивные полосы поглощения с пиками на длинах волн 937 нм и 976 нм. Максимальное поперечное сечение поглощения достигает 1.5·10–20 cм2 на длине волны 976 нм для поляризации E//Ng. В спектре поглощения в спектральной области 1425–1575 нм наблюдается набор узких полос поглощения. Измеренное время жизни верхнего уровня 4I13/2  ионов Er3+ составило 390 ± 20 мкс. Эффективность переноса энергии от ионов иттербия к ионам эрбия для кристалла Er(2 ат.%),Yb(11 ат.%):YMgB5O10 достигала 84 %. Максимальная выходная мощность лазерной генерации на длине волны 1570 нм составила 0,2 Вт при дифференциальном КПД 8 %.Благодаря высокой теплопроводности (≈ 6.2 Вт·м–1·K–1) кристалла Er,Yb:YMgB5O10 , он может быть с успехом использован в качестве активной среды для лазеров дальномерных систем и ЛИДАРов

Er,Yb:ReGa3(BO3)4 (Re = Y, Gd) laser crystals

Phase relationships in the ErxYbyY1-x-yGa3(BO3)4-Bi2O3-B2O3-(Y,Er,Yb)2O3–Ga2O3 and ErxYbyGd1-x-yGa3(BO3)4-Bi2O3-B2O3-(Gd,Er,Yb)2O3 – Ga2O3 (x = 0.02, y = 0.11 at.%) system were studied in the temperature range from 1000 to 900 оС. Multicomponent melt Bi2O3-Ga2O3-B2O3-(Y,Gd)2O3 were used as reasonable fluxes for high-temperature solution growth of ErxYbyR1-x-yGa3(BO3)4 (R = Y, Gd) spontaneous crystals. The segregation coefficients of Yb and Er impurities in the obtained crystals are determined. The unit cell parameters for the grown crystals were studied, also showing the micromorphology characteristics of the crystals. The luminescence kinetics were investigated, and the lifetimes of the 4I13/2 energy level of Er3+ ions for Er,Yb:ReGa3(BO3)4 crystals were determined

Two‑Dimensional Copper Coordination Polymer Assembled with Fumarate and 5,5’‑Dimethyl‑2,2’‑bipyridine: Synthesis, Crystal Structure and Magnetic Properties

[[Cu(fum)(dmb)]·H2O]n, exhibiting weak antiferromagnetic interactions, displays a two-dimensional array comprised of rhombic dinuclear units, where the carboxylate moieties of fumarate bridging ligand displays monodentate and oxo-bridging coordination modes connecting two Cu centers.[[Cu(fum)(dmb)]·H2O]n (1) (fum = fumarate; dmb = 5,5’-dimethyl-2,2’-bipyridine) was obtained by a self-assembly solution reaction, at ambient conditions, and characterized by elemental analysis, IR spectroscopy and X-ray single crystal diffraction. Crystallographic studies show that 1 crystallizes in a triclinic system with a P-1 space group, with a = 8.2308(2) Å, b = 9.7563(2) Å, c = 10.3990(2) Å; α = 80.3444(4)°, β = 77.9517(4)°, γ = 82.0440(5)°; V = 800.45(3) Å3. The Cu(II) centers are five-coordinated with a distorted square pyramidal configuration. The formation of a two-dimensional (2D) array in 1 can be explained by the presence of two different coordination modes in the fumarate ligand: μ-η1:η0 and μ2-η2:η0, both in a bridging monodentate manner, the latter generating distinctive rhombic-dinuclear units. The thermal stability of 1 has also been analyzed. Magnetic measurements revealed that this polymer exhibits weak antiferromagnetic ordering.Universidad Autonoma del Estado de México Universidad Nacional Autónoma de Méxic

Crystal growth and spectroscopic characterization of Yb:YMgB5O10

A transparent Yb:YMgB5O10 single crystal with dimensions up to 25×23×25 mm was grown. Absorption cross-section spectra were produced. The luminescence spectra of the Yb: YMgB5O10 crystal were measured in the spectral range of 950–1100 nm. The luminescence kinetics of the 2F5/2 energy level were investigated and the lifetime was determined

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

ПРОБЛЕМЫ ФОРМИРОВАНИЯ МУЗЫКАЛЬНОЙ КОМПЕТЕНТНОСТИ БУДУЩИХ КУЛЬТУРОЛОГОВ

The article focuses on the competency approach in education. The authors define the problems associated with training students in cultural studies. Particular attention is paid to the peculiarities of the formation of musical competence of the future specialist.Статья посвящена вопросу компетентностного подхода в образовании. Автором определяются проблемы, связанные с профессиональной подготовкой студентов-культурологов. Особое внимание уделяется особенностям процесса формирования музыкальной компетентности будущего специалиста