Comment on "Giant Nernst Effect due to Fluctuating Cooper Pairs in Superconductors" by M.N. Serbyn, M.A. Skvortsov, A.A. Varlamov, and V. Galitski

In a recent Letter, Serbyn et al. [A] investigated thermomagnetic effects above the superconducting transition and generalized previous works for arbitrary magnetic fields and temperatures. While the results of [A] have been confirmed in [B], we have strong objections: (i) According to our results [C], the linear response calculation does not require any correction from the magnetization currents; (ii) The result of [A,B] is giant, because unlike the normal Fermi liquid, it is of zero order in the particle-hole asymmetry. Changing the interaction constant in the Cooper channel leads to ridiculously large results even for nonsuperconducting metals; (iii)Derived in [A] the Einstein-type relation for thermomagnetic coefficient contradicts to text-book results. [A] M.N. Serbyn, M.A. Skvortsov, A.A. Varlamov, V. Galitski, Phys. Rev. Lett. 102, 067001 (2009). [B] K. Michaeli and A.M. Finkel'stein, EPL 86, 27007 (2009). [C] A. Sergeev et al., Phys. Rev. B 77, 064501 (2008)

Adjuvant vs. salvage radiation therapy in men with high-risk features after radical prostatectomy: Survey of North American genitourinary expert radiation oncologists

INTRODUCTION: The management of patients with high-risk features after radical prostatectomy (RP) is controversial. Level 1 evidence demonstrates that adjuvant radiation therapy (RT) improves survival compared to no treatment; however, it may overtreat up to 30% of patients, as randomized clinical trials (RCTs) using salvage RT on observation arms failed to reveal a survival advantage of adjuvant RT. We, therefore, sought to determine the current view of adjuvant vs. salvage RT among North American genitourinary (GU) radiation oncology experts. METHODS: A survey was distributed to 88 practicing North American GU physicians serving on decision-making committees of cooperative group research organizations. Questions pertained to opinions regarding adjuvant vs. salvage RT for this patient population. Treatment recommendations were correlated with practice patterns using Fisher's exact test. RESULTS: Forty-two of 88 radiation oncologists completed the survey; 23 (54.8%) recommended adjuvant RT and 19 (45.2%) recommended salvage RT. Recommendation of active surveillance for Gleason 3+4 disease was a significant predictor of salvage RT recommendation (p=0.034), and monthly patient volume approached significance for recommendation of adjuvant over salvage RT; those seeing <15 patients/month trended towards recommending adjuvant over salvage RT (p=0.062). No other demographic factors approached significance. CONCLUSIONS: There is dramatic polarization among North American GU experts regarding optimal management of patients with high-risk features after RP. Ongoing RCTs will determine whether adjuvant RT improves survival over salvage RT. Until then, the almost 50/50 division seen from this analysis should encourage practicing clinicians to discuss the ambiguity with their patients

Disproportionation and electronic phase separation in parent manganite LaMnO_3

Nominally pure undoped parent manganite LaMnO_3 exhibits a puzzling behavior inconsistent with a simple picture of an A-type antiferromagnetic insulator (A-AFI) with a cooperative Jahn-Teller ordering. We do assign its anomalous properties to charge transfer instabilities and competition between insulating A-AFI phase and metallic-like dynamically disproportionated phase formally separated by a first-order phase transition at T_{disp}=T_{JT}\approx 750 K. The unconventional high-temperature phase is addressed to be a specific electron-hole Bose liquid (EHBL) rather than a simple "chemically" disproportionated R(Mn^{2+}Mn^{4+})O_3 phase. New phase does nucleate as a result of the charge transfer (CT) instability and evolves from the self-trapped CT excitons, or specific EH-dimers, which seem to be a precursor of both insulating and metallic-like ferromagnetic phases observed in manganites. We arrive at highly frustrated system of triplet (e_g^2)^3A_{2g} bosons moving in a lattice formed by hole Mn^{4+} centers. Starting with different experimental data we have reproduced a typical temperature dependence of the volume fraction of high-temperature mixed-valent EHBL phase. We argue that a slight nonisovalent substitution, photo-irradiation, external pressure or magnetic field gives rise to an electronic phase separation with a nucleation or an overgrowth of EH-droplets. Such a scenario provides a comprehensive explanation of numerous puzzling properties observed in parent and nonisovalently doped manganite LaMnO_3 including an intriguing manifestation of superconducting fluctuations.Comment: 20 pages, 8 figure

Is moderate hypofractionation accepted as a new standard of care in north america for prostate cancer patients treated with external beam radiotherapy? Survey of genitourinary expert radiation oncologists

INTRODUCTION: Several recent randomized clinical trials have evaluated hypofractionated regimens against conventionally fractionated EBRT and shown similar effectiveness with conflicting toxicity results. The current view regarding hypofractionation compared to conventional EBRT among North American genitourinary experts for management of prostate cancer has not been investigated. MATERIALS AND METHODS: A survey was distributed to 88 practicing North American GU physicians serving on decision - making committees of cooperative group research organizations. Questions pertained to opinions regarding the default EBRT dose and fractionation for a hypothetical example of a favorable intermediate - risk prostate cancer (Gleason 3 + 4). Treatment recommendations were correlated with practice patterns using Fisher's exact test. RESULTS: Forty - two respondents (48%) completed the survey. We excluded from analysis two respondents who selected radical hypofractionation with 5 - 12 fractions as a preferred treatment modality. Among the 40 analyzed respondents, 23 (57.5%) recommend conventional fractionation and 17 (42.5%) recommended moderate hypofractionation. No demographic factors were found to be associated with preference for a fractionation regimen. Support for brachytherapy as a first choice treatment modality for low - risk prostate cancer was borderline significantly associated with support for moderate hypofractionated EBRT treatment modality (p = 0.089). CONCLUSIONS: There is an almost equal split among North American GU expert radiation oncologists regarding the appropriateness to consider moderately hypofractionated EBRT as a new standard of care in management of patients with prostate cancer. Physicians who embrace brachytherapy may be more inclined to support moderate hypofractionated regimen for EBRT. It is unclear whether reports with longer followups will impact this balance, or whether national care and reimbursement policies will drive the clinical decisions. In the day and age of patient - centered care delivery, patients should receive an objective recommendation based on available clinical evidence. The stark division among GU experts may influence the design of future clinical trials utilizing EBRT for patients with prostate cancer