The 1983 direct strike lightning data, part 1

Data waveforms are presented which were obtained during the 1983 direct strike lightning tests utilizing the NASA F106-B aircraft specially instrumented for lightning electromagnetic measurements. The aircraft was operated in the vicinity of the NASA Langley Research Center, Hampton, Virginia, in a thunderstorm environment to elicit strikes. Electromagnetic field data and conduction currents on the aircraft were recorded for attached lightning. Part 1 contains 435 pages of lightning strike data in chart form

An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival.

BackgroundIn 2016, the World Health Organization reclassified the definition of glioblastoma (GBM), dividing these tumors into isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant GBM, where the vast majority of GBMs are IDH-wild-type. Nomograms are useful tools for individualized estimation of survival. This study aimed to develop and independently validate a nomogram for IDH-wild-type patients with newly diagnosed GBM.MethodsData were obtained from newly diagnosed GBM patients from the Ohio Brain Tumor Study (OBTS) and the University of California San Francisco (UCSF) for diagnosis years 2007-2017 with the following variables: age at diagnosis, sex, extent of resection, concurrent radiation/temozolomide (TMZ) status, Karnofsky Performance Status (KPS), O6-methylguanine-DNA methyltransferase (MGMT) methylation status, and IDH mutation status. Survival was assessed using Cox proportional hazards regression, random survival forests, and recursive partitioning analysis, with adjustment for known prognostic factors. The models were developed using the OBTS data and independently validated using the UCSF data. Models were internally validated using 10-fold cross-validation and externally validated by plotting calibration curves.ResultsA final nomogram was validated for IDH-wild-type newly diagnosed GBM. Factors that increased the probability of survival included younger age at diagnosis, female sex, having gross total resection, having concurrent radiation/TMZ, having a high KPS, and having MGMT methylation.ConclusionsA nomogram that calculates individualized survival probabilities for IDH-wild-type patients with newly diagnosed GBM could be useful to physicians for counseling patients regarding treatment decisions and optimizing therapeutic approaches. Free software for implementing this nomogram is provided: https://gcioffi.shinyapps.io/Nomogram_For_IDH_Wildtype_GBM_H_Gittleman/

Tudor Conciliar Theorists

This thesis analyzes a variety of sources such as printed books, diplomatic correspondence, letters, and notes, from which a description of Tudor ideas in relation to proposals to hold a general council can be derived. This Tudor Conciliar Theory has a definite beginning. Henry VIII developed a flexible foreign policy to deal with continental suggestions to hold a general council of the church. The position which he took was that the English nation was not opposed to such a gathering, but on every occasion, matters of detail were used to block English participation. While these procedural details kept Henry from participating, a second wall of defense was raised: Henrician propagandists insisted that the princes of Christendom, not the pope, should be instrumental in calling a council into session. The authority to call a council into being implied, of course, the power to control its proceedings, which was a crucial point in Henry\u27s campaign to vindicate his decision to divorce Catherine of Aragon. Thomas Cranmer, archbishop of Canterbury, was in agreement with these Henrician ideas. He, in turn, planted the essence of Henrician conciliar thought into article twenty-two of the 42 Articles of Edward VI. Under the reign of Elizabeth, this article became number twenty-one of the Thirty-Nine Articles of Religion, the basis of the Anglican settlement. Later apologists, defending Elizabeth\u27s refusal to participate in the concluding sessions of the council of Trent used arguments similar to those advanced by her father\u27s propagandists. Such men as John Bale, John Jewel, Thomas Cartwright, John Foxe, William Whitaker, and John Whitgift followed the system of ideas that was developed in the 1530\u27s. English translations of European writers, (which provide sure evidence of someone in England having read them) disclose no indebtedness to any continental school of thought. Some of the best protestant arguments against the proposals to hold a general council, by Calvin and Luther, were never translated. Thus, aside from the influence of fourteenth and fifteenth century conciliar writers, there was a distinctive English conciliar theory, apart from continental thought. The aim of this English conciliar theory was to allow the princes of Christendom a measure of power over the general council. It enlarged the arena wherein the king held dominion over the church and diminished the territory over which the general council had jurisdiction. Petty objections to procedural details revealed a hostility to the general council itself, revealed the aversion of these Englishmen to the idea of allowing this foreign institution to limit the power of the king

Dephasing due to Intermode Coupling in Superconducting Stripline Resonators

The nonlinearity exhibited by the kinetic inductance of a superconducting stripline couples stripline resonator modes together in a manner suitable for quantum non-demolition measurement of the number of photons in a given resonator mode. Quantum non-demolition measurement is accomplished by coherently driving another resonator mode, referred to as the detector mode, and measuring its response. We show that the sensitivity of such a detection scheme is directly related to the dephasing rate induced by such an intermode coupling. We show that high sensitivity is expected when the detector mode is driven into the nonlinear regime and operated close to a point where critical slowing down occurs

Budd-Chiari syndrome recurring in a transplanted liver

A patient with Budd-Chiari syndrome who underwent orthotopic liver transplantation and developed recurrent disease is described. The immediate postoperative period was complicated by multiple thrombotic episodes, followed by a period of apparent remission associated with the initiation of coumadin and persantine therapy. After discontinuation of such antithrombotic therapy in order to biopsy the liver, the patient experienced another series of clinically overt vascular thromboses and ultimately died of sepsis 15 mo posttransplantation after a prolonged and complicated terminal hospital course. At autopsy, recurrent Budd-Chiari syndrome as well as thromboses in numerous other organs was demonstrated. © 1983

The 1983 direct strike lightning data, part 2

Data waveforms are presented which were obtained during the 1983 direct strike lightning tests utilizing the NASA F106-B aircraft specially instrumented for lightning electromagnetic measurements. The aircraft was operated in the vicinity of the NASA Langley Research Center, Hampton, Virginia, in a thunderstorm environment to elicit strikes. Electromagnetic field data and conduction currents on the aircraft were recorded for attached lightning. Part 2 contains 443 pages of lightning strike data in chart form

Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax.

Anopheles darlingi Root is the most important malaria vector in the Amazonia region of South America. However, continuous propagation of An. darlingi in the laboratory has been elusive, limiting entomological, genetic/genomic, and vector-pathogen interaction studies of this mosquito species. Here, we report the establishment of an An. darlingi colony derived from wild-caught mosquitoes obtained in the northeastern Peruvian Amazon region of Iquitos in the Loreto Department. We show that the numbers of eggs, larvae, pupae, and adults continue to rise at least to the F6 generation. Comparison of feeding Plasmodium vivax ex vivo of F4 and F5 to F1 generation mosquitoes showed the comparable presence of oocysts and sporozoites, with numbers that corresponded to blood-stage asexual parasitemia and gametocytemia, confirming P. vivax vectorial capacity in the colonized mosquitoes. These results provide new avenues for research on An. darlingi biology and study of An. darlingi-Plasmodium interactions