Formulation and Evaluation of Modified release Bilayer Tablet of Paracetamol and Diclofenac sodium

The main objective of this research work is to develop a stable formulation of a NASAID drugs an immediate release layer of Paracetamol and sustain release layer of Diclofenac sodium are combine to the bilayer and evaluate their pre-compression and post-compression parameters A bilayer tablet comprises first layer formulated for instant release of the paracetamol from a dissolving tablet and a second layer formulated for sustain release Diclofenac sodium from a bilayer tablet The formulation was initiated with preparing granules of both the drug individually by wet granulation method and then then they were compressed to prepare bilayer tablet. The compressed bilayer tablets were evaluated for weight variation, thickness, hardness, friability, in-vitro drug release using USP dissolution apparatus and interaction study by DSC. The optimized Formulation table of formulations F5 formulation was found to be acceptable because it release drug up to 82.11 % of drug release for bilayer Tablet and this batch passed all the evaluation parameters

Efficacy of Quasi Agro Binding Fibre on the Hybrid Composite Used in Advance Application

The choice for natural fibre obtained from agricultural products is on the rise due to its solution to eco-friendly, environmental and improved mechanical properties concerns. Its abundant availability, low cost, emission reduction and adaptability to base material for composite make it a prime material for selection. This review explores diverse perspectives to the future trend of agro fibre in terms of the thermo-mechanical properties as it applies to advanced application in building structures. It is important to investigate the ecofriendliness of the products of composites from fibres in agricultural wastes so as to achieve a green and sustainable environment. This will come to fore by the combined efforts of both researchers and feedback from building stakeholders

Analysis of NACA 4415 Blade Profile for Horizontal Axis Wind Turbine Using Various Aerodynamic Characteristics

Volume 7 Issue 7 (July 201

Targeting human telomeric G-quadruplex DNA with curcumin and its synthesized analogues under molecular crowding conditions

The formation of telomeric G-quadruplexes has been shown to inhibit telomerase activity. Indeed, a number of small molecules capable of p-stacking with G-tetrads have shown the ability to inhibit telomerase activity through the stabilization of G-quadruplexes. Curcumin displays a wide spectrum of medicinal properties ranging from anti-bacterial, anti-viral, anti-protozoal, anti-fungal and anti-inflammatory to anti-cancer activity. We have investigated the interactions of curcumin and its structural analogues with the human telomeric sequence AG(3)(T(2)AG(3))(3) under molecular crowding conditions. Experimental studies indicated the existence of a AG(3)(T(2)AG(3))(3)/curcumin complex with binding affinity of 0.72 x 10(6) M-1 under molecular crowding conditions. The results from UV-visible absorption spectroscopy, a fluorescent TO displacement assay, circular dichroism and molecular docking studies, imply that curcumin and their analogues interact with G-quadruplex DNA via groove binding. While other analogs of curcumin studied here bind to G-quadruplexes in a qualitatively similar manner their affinities are relatively lower in comparison to curcumin. The Knoevenagel condensate, a methoxy-benzylidene derivative of curcumin, also exhibited significant binding to G-quadruplex DNA, although with two times decreased affinity. Our study establishes the potential of curcumin as a promising natural product for G-quadruplex specific ligands

Antioxidant activity and electrochemical elucidation of the enigmatic redox behavior of curcumin and its structurally modified analogues

Here, we report studies on the antioxidant activity and redox behavior of curcumin and its structurally modified synthetic analogues. We have synthesized a number of analogues of curcumin which abrogate its keto-enol tautomerism or substitute the methylene group at the centre of its heptadione moiety implicated in the hydride transfer and studied their redox property. From cyclic voltammetric studies, it is demonstrated that H-atom transfer from CH2 group at the center of the heptadione link also plays an important role in the antioxidant properties of curcumin along with that of its phenolic -OH group. In addition, we also show that the conversion of 1, 3-dicarbonyl moiety of curcumin to an isosteric heterocycle as in pyrazole curcumin, which decreases its rotational freedom, leads to an improvement of its redox properties as well as its antioxidant activity. (C) 2014 Elsevier Ltd. All rights reserved

PREVALENCE OF CARDIO-VASCULAR DISEASE (CVD) RISK FACTORS AMONG AUTO-RICKSHAW DRIVERS

Research question: What is the prevalence of some cardio-vascular disease (CVD) risk factors among auto-rickshaw drivers (ARDs) working in Nagpur city of India? Methods: This cross-sectional study was conducted from June 2007 to December 2008 at the auto-rickshaw stand of Nagpur railway station. Out of total 6000 auto-rickshaw drivers (ARDs) of Nagpur city, 296 were studied. Results: Mean age of ARDs was 41.70±9.05 years. Their mean length of occupation was 17 years and average daily working was 11½ hours. 40.20% subjects had habit of tobacco chewing; while 35.14% were smokers and 34.12% were alcohol consumers. Only 16.89% subjects were engaged in regular physical exercise. 27.36% subjects had ‘moderate’ or ‘severe’ self reported stress. Mean weight of these auto-rickshaw drivers was 58.59±9.25 kg; while their mean body mass index (BMI) was 21.95±3.48 kg/m2. 14.86% subjects were overweight and another 3.38% had obesity. 37.16% subjects had pre-hypertension; while 104 (35.14%) subjects had hypertension. 4.73% of the ARDs also had a family history of hypertension. Conclusions: As the prevalence of various CVD risk factors is high; there is an urgent need of regular health check-ups and appropriate preventive and promotive interventions among these auto-rickshaw drivers