Anticancer Potential of Furanocoumarins: Mechanistic and Therapeutic Aspects

Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins' defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents

Quantification of three macrolide antibiotics in pharmaceutical lots by HPLC: Development, validation and application to a simultaneous separation

A new validated high performance liquid chromatographic (HPLC) method with rapid analysis time and high efficiency, for the analysis of erythromycin, azithromycin and spiramycin, under isocratic conditions with ODB RP18 as a stationary phase is described. Using an eluent composed of acetonitrile –2-methyl-2-propanol –hydrogenphosphate buffer, pH 6.5, with 1.5% triethylamine (33:7: up to 100, v/v/v), delivered at a flow-rate of 1.0 mL min-1. Ultra Violet (UV) detection is performed at 210 nm. The selectivity is satisfactory enough and no problematic interfering peaks are observed. The procedure is quantitatively characterized and repeatability, linearity, detection and quantification limits are very satisfactory. The method is applied successfully for the assay of the studied drugs in pharmaceutical dosage forms as tablets and powder for oral suspension. Recovery experiments revealed recovery of 97.13–100.28%

Zonation of groundwater quality for agricultural purposes using GIS technology in Khouzestan - Avan plain

Aim. Appreciation of hydrochemical and zonation status helps us to describe various strategies for water abstraction which has application for various purposes including agriculture. GIS can play a significant role in the analysis of suitable sites by considering the water quality requirements of agriculture and identifying and mapping locations within a region that meet these necessities. The purpose of this article is to use GIS technology for qualitative zonation of Avan groundwater resources for agricultural purposes. Methods. Mapping groundwater quality zoning based on physico chemical data in 18 wells were Avan plain import data environments with GIS, layers and Na, SAR, Ec and comparative RSC interpolation was prepared, according to the prepared layers Boolean logic layers to create zoning and finally the overlapping layers creation by a final map quality in terms of agricultural zoning, respectively. Results and conclusion. Based on early plain zoning maps, approximately half of the Plains (southern part of West and North) in the category of inappropriate agricultural placed. These maps can show the locations which are suitable for agriculture and decision makers can manage the region by considering the quality of water in selected areas by updating the information

Effect of Application of Biofertilizers and Phosphorus Fertilizers on Qualitative and Quantitative Traits of Spring Wheat (Triticum aestivum L.)

In order to study the effects of biofertilizer and phosphate fertilizer on yield and yield components of spring wheat a factorial experiment based on randomized completed blocks design with replications was conducted at the Mohsenabad, Mehran Research station in Ilam, Iran during 2009-2010. Experimental factors consisted of phosphorus chemical fertilizers at four levels(0, 90, 135 and 180 kg ha-1) and bio-fertilizer at four levels (non-inoculation, inoculating with Azotobacter chroococcum, Pseudomonas Putida and Azotobacter plus Pseudomonas). Results of analysis variance showed that using chemical fertilizer significantly effected grain yield, harvest index, biological yield, plant height and protein content. The highest grain and biological yields were produced by applying180 kg ha-1, while its effects on other traits were not significantly different from that of 135 kg ha-1. Biological fertilizers, on the other hand increased grain yield, harvest index, biological yield, plant height and protein content as compared to non inoculation treatment. The highest grain yield, harvest index, biological yield, plant height and protein content obtained from application of Azotobacter plus Pseudomonas. Grain yield, harvest index, biological, plant height were affected by interaction effects of chemical fertilizer and biological fertilizers. The highest and lowest grain yield belonged to the application of 180 kg ha-1 of chemical fertilizer and Azotobacter plus Pseudomonas and non- chemical fertilizer and non-inoculation, respectively, but the difference between 135 and 180 kg.ha-1 was not statistically different. Thus, it is cheaper to recommend use of 135 kg ha-1 of chemical fertilizer and Azotobacter plus Pseudomonas to get acceptable grain and biological yields

Anticancer potential of furanocoumarins: Mechanistic and therapeutic aspects

Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins’ defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents

Anticancer potential of furanocoumarins: Mechanistic and therapeutic aspects

Cancer is one of the most extreme medical conditions in both developing and developed countries around the world, causing millions of deaths each year. Chemotherapy and/or radiotherapy are key for treatment approaches, but both have numerous adverse health effects. Furthermore, the resistance of cancerous cells to anticancer medication leads to treatment failure. The rising burden of cancer overall requires novel efficacious treatment modalities. Natural medications offer feasible alternative options against malignancy in contrast to western medication. Furanocoumarins' defensive and restorative impacts have been observed in leukemia, glioma, breast, lung, renal, liver, colon, cervical, ovarian, and prostate malignancies. Experimental findings have shown that furanocoumarins activate multiple signaling pathways, leading to apoptosis, autophagy, antioxidant, antimetastatic, and cell cycle arrest in malignant cells. Additionally, furanocoumarins have been shown to have chemo preventive and chemotherapeutic synergistic potential when used in combination with other anticancer drugs. Here, we address different pathways which are activated by furanocoumarins and their therapeutic efficacy in various tumors. Ideally, this review will trigger interest in furanocoumarins and their potential efficacy and safety as a cancer lessening agents

Publisher Correction: Model-Based Therapy Planning Allows Prediction of Haemodynamic Outcome after Aortic Valve Replacement (vol 7, Art. 9897, 2018)

Correction to: Scientific Reports https://doi.org/10.1038/s41598-017-03693-x, published online 29 August 2017 The original version of this Article contained a typographical error in the spelling of the author V. Falk, which was incorrectly given as Falk. This has now been corrected in the PDF and HTML versions of the Article