The Influence of Task Type on Perceived Fluency

In foreign language teaching it is necessary to employ a variety of tasks with a different degree of narrative structure to influence learners’ performance in anticipated ways, thus enhancing overall fluency as a significant aspect of successful communication. This study examines how different task types influence the perceived fluency of EFL learners. The obtained results confirm that the perception of speakers’ fluency varied across tasks. The worst perception of fluency was achieved in the task based on the formulation of unrelated utterances, that is, the most unstructured task led to the least fluent performance. A frequent introduction of new topics demands a great amount of attention. Therefore, in foreign language teaching emphasis should be laid on tasks including frequent introductions of new topics, due to the observed decrease in perceived fluency

Repetitions as a Communication Strategy: A Case Study

This extensive study examines repetitions in English (L2) which are considered as indicators of speech disfluency as well as a communication strategy. The participants of this study were 101 first-year undergraduate students of technical studies who received nine years of formal instruction of English. The results revealed that the speakers tend to repeat shorter speech fragments, that is, the absolute majority of all repetitions comprised up to one syllable. Consequently, even shorter repetitions generally provide sufficient additional time for linguistic planning or retrieving a particular linguistic unit. The former conclusion refers to both L1 and L2 repetitions. However, the comparison with the results obtained for L1 in a previous study confirmed that the speakers in L2 employ considerably more repetitions compared to L1. This points to the conclusion that repetitions as a communication strategy in L2 are used in order to give the speaker the opportunity to hold the floor, namely, it prevents breakdowns in communication. Even though repetitions are considered as forms of speech disfluency, they are indeed a resource learners can use in order to engage in a conversation despite their limited language resources

Communication Strategies in Use: The Implementation of Predetermined Vocabulary in the Classroom

The goal of the research was to examine the usefulness of formal strategy teaching in the classroom, that is, to explore to what extent the strategy of teaching predetermined L2 vocabulary enhances students’ oral communication skills. Two groups of participants were compared, the students of Electrical Engineering and Information Technology, and students of Mechanical Engineering. The former attended the course Communication Skills and were already familiar with certain communication models and means of making and maintaining conversation, and delivering presentations. The latter group, the Mechanical Engineering students did not attend such classes, so they represented the comparison class in this research. The results showed that the students who attended the communication skills course showed better presentations skills and the usage of predetermined phrases. Moreover, predetermined vocabulary helps less successful students with the deficit of L2 competencies. This communication strategy helps students with poorer English knowledge acquire the language competences as well as improve their confidence

Influence of Cyp2c19∗2 Gene Variant on Therapeutic Response during Clopidogrel Treatment in Patients with Carotid Artery Stenosis

Background: Despite the proven clinical effect of oral antiplatelet drugs, a considerable number of patients do not have an adequate response to clopidogrel. The aim of our study was to determine the influence of CYP2C19*2 loss-of-function variant allele on clopidogrel responsiveness in patients with carotid artery stenosis. Methods: One hundred and twelve patients with carotid artery stenosis undergoing endarterectomy were included in this one-year prospective study. All of them received clopidogrel (75 mg daily) for at least 30 days after the intervention. They were followed from the moment of hospital admission. CYP2C19*2 genotyping was performed by TaqMan Assay. The influence of CYP2C19*2 variant allele on clopidogrel platelet reactivity was determined using multiple-electrode aggregometry (MEA). Results: Genotyping results showed that 82 (73.2%) patients were homozygous for wild type, 29 (25.9%) were heterozygous for the CYP2C19*2 allele and 1 (0.9%) was CYP2C19*2 homozygous. After 24 hours, among those with the wild type 29.3% were clopidogrel responders, and in those with the CYP2C19*2 alleles 10%. In the wild type group, 74.4% were clopidogrel responders after 7 days of taking the drug; 82.9% after 30 days of clopidogrel introduction, respectively. In patients with the CYP2C19*2 alleles the number of responders increased up to 46.7% after 7 days; 53.3% after 30 days of taking the drug, respectively. The risk for being a low-responder is higher for the patients heterozygous for the CYP2C19*2 allele vs. wild type (OR 4.250, 95% CI 1.695-10.658, P lt 0.01). Conclusions: The CYP2C19*2 loss-of-function variant allele has significant influence on clopidogrel response in patients with carotid artery stenosis undergoing endarterectomy

Intermittent Chemotherapy and Erlotinib for Nonsmokers or Light Smokers with Advanced Adenocarcinoma of the Lung: A Phase II Clinical Trial

Background. Intermittent application of chemotherapy and tyrosine kinase inhibitors may avoid antagonism between the two classes of drugs. This hypothesis was tested in a Phase II clinical trial. Patients and Methods. Eligible patients were nonsmokers or light smokers, chemo-naïve, with metastatic adenocarcinoma of the lung. Treatment: 4 to 6 cycles of gemcitabine 1250 mg/m2 on days 1 and 4, cisplatin 75 mg/m2 on day 2, and erlotnib 150 mg daily on days 5–15, followed by erlotinib as maintenance. Results. 24 patients entered the trial. Four pts had grade 3 toxicity. Complete remission (CR) and partial remission (PR) were seen in 5 pts and 9 pts, respectively (response rate 58%). Median time to progression (TTP) was 13.4 months and median overall survival (OS) was 23 months. When compared to patients with negative or unknown status of EGFR mutations, 8 patients with EGFR gene activating mutations had significantly superior experience: 4 CR and 4 PR, with median TTP 21.5 months and OS 24.2 months (P  <  .05). Conclusions. Intermittent schedule with gemcitabine, cisplatin and erlotinib has mild toxicity. For patients who are positive for EGFR gene activating mutations, this treatment offers excellent response rate, time to progression and survival

Early onset of abdominal venous thrombosis in a newborn with homozygous type II heparin-binding site antithrombin deficiency

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