Paleocorología de los mamíferos del Mioceno medio de Somosaguas (Pozuelo de Alarcón, Madrid)

A palaeochorological study of the mammalian fauna from Somosaguas (Pozuelo de Alarcón, Madrid) during the middle Miocene (Aragonian, MN5, local biozone E, 14 Ma) has shown two main types of biogeographical distributions: endemisms and species with wide distribution. Comparison with the modern fauna from Madrid reveals that the proportion of endemic species was slightly higher 14 million years ago. Probably, this is related to the Neogene global cooling trend, which has made the Iberian Peninsula shift from the Palaeotropical biogeographic realm to the Palaearctic realm. As a result, modern Iberian faunas have become more similar to central European ones than in the Miocene

Auditoria a las cuentas corrientes bancarias en un sistema computarizado

220 p.El presente trabajo contempla el Estudio del Movimiento Generalizado de las Cuentas Corrientes en los bancos comerciales de nuestro país con el objeto de tomar conocimiento respecto al funcionamiento de 1a Cuenta Corriente Bancaria en Chile, ello ha permitido desarrollar una secuencia metodologica para la realización de una Auditoria a las Cuentas Corrientes Bancarias, sea que el procesamiento de la información se realice en forma manual o computarizada. La realización de esta investigación, fue posible gracias a la inquietud de un grupo do alumnos, quienes conscientes de la importancia que reviste la Cuenta Corriente bancaria en la economía actual Como fuente de financiamiento bancario y su relación con el Procesamiento Electrónico de datos, vieron la necesidad de contar con una herramienta metodologica que permite evaluar la razonabilidad del saldo de las cuentas corrientes presentado en los Estados Financieros Bancarios. Este seminario fue confeccionado durante el segundo semestre del año 1982 y primer semestre de 1983, por un grupo de alumnos de la Escuela de Ciencias Económicas y Administrativas de la universidad de Talca, como requisito para completar el Plan de Estudios de la carrera de Contador Público y Contador Auditor

SINDE V. 1.0: Desarrollo de un soporte informático sobre nutrición y dietética para Enfermería

SINDE v. 1.0, es un programa multimedia resultado de una combinación de aspectos pedagógicos, informáticos y curriculares, que pretende ser un método innovador de aprendizaje, que de forma clara, interactiva e intuitiva desarrolle el contenido de la asignatura de "Nutrición y Dietética" de la diplomatura de enfermería de la Universidad Pública de Navarra. Se ha desarrollado con Director 6.0. e incluye dibujos, gráficos, animaciones, sonido y otros recursos multimedia. La implantación del programa que se presenta en CD-ROM se llevará a cabo, bajo entorno windows, para uso de los estudiantes de enfermería, y se utilizarán distintas herramientas para la validación del programa

Isotope analyses to explore diet and mobility in a medieval Muslim population at Tauste (NE Spain)

The Islamic necropolis discovered in Tauste (Zaragoza, Spain) is the only evidence that a large Muslim community lived in the area between the 8th and 10th centuries. A multi-isotope approach has been used to investigate the mobility and diet of this medieval Muslim population living in a shifting frontier region. Thirty-one individuals were analyzed to determine delta N-15, delta C-13, delta O-18 and Sr-87/Sr-86 composition. A combination of strontium and oxygen isotope analysis indicated that most individuals were of local origin although three females and two males were non-local. The non-local males would be from a warmer zone whereas two of the females would be from a more mountainous geographical region and the third from a geologically-different area. The extremely high delta(15) N baseline at Tauste was due to bedrock composition (gypsum and salt). High individual delta(15) N values were related to the manuring effect and consumption of fish. Adult males were the most privileged members of society in the medieval Muslim world and, as isotope data reflected, consumed more animal proteins than females and young males.Research Group GIU15/34 of the University of the Basque provided support to MO, XM, Country-UPV/EHU, http://www.ehu.eus/es/web/ikerkuntza. IT315-10 Research Group of the Basque Country Government provided support to IG LO MCZ, http://www.hezkuntza.ejgv.euskadi.eus/r43-5553/es/

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respectively. We identified several genes harboring rare loss-of-function variants in ~200,000 women, including variants in ZNF483, which abolished the impact of polygenic risk. Variant-to-gene mapping approaches and mouse gonadotropin-releasing hormone neuron RNA sequencing implicated 665 genes, including an uncharacterized G-protein-coupled receptor, GPR83, which amplified the signaling of MC3R, a key nutritional sensor. Shared signals with menopause timing at genes involved in DNA damage response suggest that the ovarian reserve might signal centrally to trigger puberty. We also highlight body size-dependent and independent mechanisms that potentially link reproductive timing to later life disease

Antidiabetic Drug Prescription Pattern in Hospitalized Older Patients with Diabetes

Objective: To describe the prescription pattern of antidiabetic and cardiovascular drugs in a cohort of hospitalized older patients with diabetes. Methods: Patients with diabetes aged 65 years or older hospitalized in internal medicine and/or geriatric wards throughout Italy and enrolled in the REPOSI (REgistro POliterapuie SIMI—Società Italiana di Medicina Interna) registry from 2010 to 2019 and discharged alive were included. Results: Among 1703 patients with diabetes, 1433 (84.2%) were on treatment with at least one antidiabetic drug at hospital admission, mainly prescribed as monotherapy with insulin (28.3%) or metformin (19.2%). The proportion of treated patients decreased at discharge (N = 1309, 76.9%), with a significant reduction over time. Among those prescribed, the proportion of those with insulin alone increased over time (p = 0.0066), while the proportion of those prescribed sulfonylureas decreased (p < 0.0001). Among patients receiving antidiabetic therapy at discharge, 1063 (81.2%) were also prescribed cardiovascular drugs, mainly with an antihypertensive drug alone or in combination (N = 777, 73.1%). Conclusion: The management of older patients with diabetes in a hospital setting is often sub-optimal, as shown by the increasing trend in insulin at discharge, even if an overall improvement has been highlighted by the prevalent decrease in sulfonylureas prescription

The “Diabetes Comorbidome”: A Different Way for Health Professionals to Approach the Comorbidity Burden of Diabetes

(1) Background: The disease burden related to diabetes is increasing greatly, particularly in older subjects. A more comprehensive approach towards the assessment and management of diabetes’ comorbidities is necessary. The aim of this study was to implement our previous data identifying and representing the prevalence of the comorbidities, their association with mortality, and the strength of their relationship in hospitalized elderly patients with diabetes, developing, at the same time, a new graphic representation model of the comorbidome called “Diabetes Comorbidome”. (2) Methods: Data were collected from the RePoSi register. Comorbidities, socio-demographic data, severity and comorbidity indexes (Cumulative Illness rating Scale CIRS-SI and CIRS-CI), and functional status (Barthel Index), were recorded. Mortality rates were assessed in hospital and 3 and 12 months after discharge. (3) Results: Of the 4714 hospitalized elderly patients, 1378 had diabetes. The comorbidities distribution showed that arterial hypertension (57.1%), ischemic heart disease (31.4%), chronic renal failure (28.8%), atrial fibrillation (25.6%), and COPD (22.7%), were the more frequent in subjects with diabetes. The graphic comorbidome showed that the strongest predictors of death at in hospital and at the 3-month follow-up were dementia and cancer. At the 1-year follow-up, cancer was the first comorbidity independently associated with mortality. (4) Conclusions: The “Diabetes Comorbidome” represents the perfect instrument for determining the prevalence of comorbidities and the strength of their relationship with risk of death, as well as the need for an effective treatment for improving clinical outcomes

Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both

Background and objective: Chronic obstructive pulmonary disease (COPD) and heart failure (HF) mutually increase the risk of being present in the same patient, especially if older. Whether or not this coexistence may be associated with a worse prognosis is debated. Therefore, employing data derived from the REPOSI register, we evaluated the clinical features and outcomes in a population of elderly patients admitted to internal medicine wards and having COPD, HF or COPD + HF. Methods: We measured socio-demographic and anthropometric characteristics, severity and prevalence of comorbidities, clinical and laboratory features during hospitalization, mood disorders, functional independence, drug prescriptions and discharge destination. The primary study outcome was the risk of death. Results: We considered 2,343 elderly hospitalized patients (median age 81 years), of whom 1,154 (49%) had COPD, 813 (35%) HF, and 376 (16%) COPD + HF. Patients with COPD + HF had different characteristics than those with COPD or HF, such as a higher prevalence of previous hospitalizations, comorbidities (especially chronic kidney disease), higher respiratory rate at admission and number of prescribed drugs. Patients with COPD + HF (hazard ratio HR 1.74, 95% confidence intervals CI 1.16-2.61) and patients with dementia (HR 1.75, 95% CI 1.06-2.90) had a higher risk of death at one year. The Kaplan-Meier curves showed a higher mortality risk in the group of patients with COPD + HF for all causes (p = 0.010), respiratory causes (p = 0.006), cardiovascular causes (p = 0.046) and respiratory plus cardiovascular causes (p = 0.009). Conclusion: In this real-life cohort of hospitalized elderly patients, the coexistence of COPD and HF significantly worsened prognosis at one year. This finding may help to better define the care needs of this population