En busca del agua

Datos y claves para entender por qué el financiamiento para contar con ese recurso en el ámbito rural es una inversión con fuerte retorno social.EEA Alto ValleFil: Gornitzky, Cora Miriam. Instituto De Investigación Investigación y Desarrollo Tecnológico para la Agricultura Familiar Región Pampeana; ArgentinaFil: Cali, Maria Julieta. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Alto Valle; Argentin

Determinación microanálitica de colesterol total en tejidos

En los estudios clínicos de drogas hipolipemiantes y en otros, se describe1,2 que los incrementos de colesterol total y el asociado a las LDL-C constituyen factores de riesgo principales para padecer de atereosclerosis y enfermedades asociadas a ellas, tales como infarto cardíaco, accidentes vasculares encefálicos, etc

Editoriales independientes y autogestivas: la emergencia del periodismo narrativo en la construcción del catálogo

El presente trabajo analiza las decisiones de un conjunto de editores independientes que incorporaron a sus catálogos autores emergentes y clásicos de la narrativa periodística. Para ello se abordan las estrategias de cinco editoriales argentinas: Marea (Buenos Aires); Pixel (La Plata); Recovecos (Córdoba), Baltasara y Casa Grande (Rosario). Esta aproximación a sus prácticas editoriales se inscribe en el marco del proyecto de investigación “La edición en la era de redes. Entre el artesanado y las tecnologías digitales”, radicado en la Universidad Nacional de Quilmes. Según el relevamiento realizado por este equipo de investigación, actualmente existen 426 editoriales independientes y pequeños sellos “emergentes”. Las cinco editoriales analizadas se destacan por visibilizar textos narrativos de no ficción, en cuatro ciudades de significativa producción periodística.Facultad de Periodismo y Comunicación Socia

CHEMICAL STUDY OF THE CARNAUBA (Copernicia cerifera Martius) WAX

Se realizó el estudio de la composición química de la cera de Carnauba (Copernicia cerifera Martius) una palma que crece en Argentina, Brasil y Paraguay. Cuando se realiza previamente su hidrólisis basica, se aistan e identifican fracciones que contienen diferentes grupos de compuestos, entre los que mencionamos: alcoholes grasos de alto peso molecular (C24-C16) en donde el l-dutriacontanoi es ei alcohol principal; ácidos grasos de mediano peso molecular (C12-C20) en donde el ácido hexadecanoico es el mas abundante y de alto peso molecular (C24-C36) donde el ácido octacosanoico es el mas abundante. Así como hidrocarburos de la serie homóloga a dichos alcoholes entre las que se destaca el heptacosano. Ádemas, fueron aislados 4 hidroxi-ácidos: ácido 16- hidroxihexadecanoico, ácido 18-hidroxioctadecanoico asi como acido 26-hidroxihexacosanoico y ácido 28-hidroiyoctacosanoico. Durante el desarrollo del trabajo no se observo la presencia de ácidos hidroxiacidos, insaturados . Estos compuestos fueron caracterizados mediante el estudio de las propiedades cromatográficas y espectroscópicas de cada uno de estos grupos de compuestos

Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses

The synthesis of a library of halogenated rocaglate derivatives belonging to the flavagline class of natural products, of which silvestrol is the most prominent example, is reported. Their antiviral activity and cytotoxicity profile against a wide range of pathogenic viruses, including hepatitis E, Chikungunya, Rift Valley Fever virus and SARS-CoV-2, were determined. The incorporation of halogen substituents at positions 4′, 6 and 8 was shown to have a significant effect on the antiviral activity of rocaglates, some of which even showed enhanced activity compared to CR-31-B and silvestrol

Ethisch und sozial wünschenswerte Technikgovernance fördern : Points to Consider zu Technikgovernance - Handlungsempfehlungen zum Autonomen Fahren und zu Deepfakes

Diese Broschüre fasst die zentralen Ergebnisse des Projekts TANGO (‚Technik-Innovation: sozialwissenschaftliche und ethische Analysen zu Governance‘) zusammen, das vom Bundesministerium für Bildung und Forschung (BMBF) von Januar 2019 bis Dezember 2020 gefördert wurde. Ziel des Projekts war es, aus einer Analyse unterschiedlicher Innovationsfelder abzuleiten, wie die Governance technologischer Innovationen erfolgen kann, um eine ethisch und gesellschaftlich wünschenswerte Technikentwicklung (und -anwendung) zu erreichen Die Forschungsarbeit im Projekt TANGO zeigte, dass in den Innovationsfeldern autonomes Fahren und Deepfakes zahlreiche ethische Herausforderungen stecken und deren Governance daher von großer gesellschaftlicher Bedeutung ist. Gleichzeitig berücksichtigen Governancemechanismen auf verschiedenen Ebenen unterschiedlich stark ethische, rechtliche und gesellschaftliche Aspekte, und variieren in ihrer Wirksamkeit innerhalb und zwischen den Fallstudien.This brochure summarizes the key findings of the TANGO project ('Technology Innovation: Social Science and Ethical Analyses of Governance'), which was funded by the Federal Ministry of Education and Research (BMBF) from January 2019 to December 2020. was funded. The aim of the project was to derive from an analysis of different fields of innovation how the governance of technological innovation can be done in order to achieve an ethically and The research work in the TANGO project showed that there are numerous ethical challenges in the innovation fields of autonomous driving and deepfakes and that their governance is therefore of great social importance. At the same time, governance mechanisms at different levels take into account ethical, legal and societal aspects to varying degrees, and vary in their effectiveness within and between case studies

Determination_of D003 by capillary gas chromatography

D003 is a mixture of saturated very long-chain fatty acids ranging from 24 to 36 carbon atoms, obtained from sugar cane (Saccharum officinarum L.) wax, with antiplatelet, 'antithrombotic, antioxidant and cholesterol-lowering effects . A capillary gas chromatographic method for the determination of this product was developed and validated . The acids were analyzed as methyl ester derivatives and separated in a BP-5 widebore column using 1-nonacosanoic acid as internal standard . A good linearity (r > 0 .99; CVs of the response factors and of the slopes lower than 5 and 2 %, respectively) ; as well as absence of bias was found for both, total and individual acids in the whole studied concentration range, from 30 to 150 % of the nominal mass . Quantitative recoveries (98 .9 and 100 .62 %) and good intermediate precision (CV = 0 .96 %) were also obtained . The specificity study showed no interferences regarding the determination of this mixture, once the samples were submitted to stress conditions. According to these results, it can be ensure that the validated procedure is appropriate for the quality control and stability studies of this product

Metodologías analíticas aplicadas al D003, nuevo ingrediente activo obtenido de la cera de la caña de azúcar

El D003 es un nuevo ingrediente activo, formado por una mezcla de ácidos grasos saturados lineales entre 24 a 36 átomos de carbono, el cual es aislado y purificado a partir de la cera de caña de azúcar (Saccharum officinarum L.) y ha mostrado efecto hipolipemiante, antiagregante plaquetario, anti-oxidante y antiosteopor ótico. A partir de este ingrediente activo se han elaborado suspensiones acuosas para los estudios preclínicos y tabletas con dosis de 5 y 10 mg, todo lo cual ha requerido el desarrollo y validación de metodologías analíticas por cromatograf ía de gases para su determinación en las diferentes formas en que se le utiliza. Estas metodologías se basan en el empleo de una columna semicapilar DB-5 y del ácido 1-nonadecanoico como patrón interno. Los ácidos grasos son analizados como ésteres metílicos, para cuya formación se usa una disolución de ácido clorhídrico al 5 % en metanol. Los resultados de las validaciones demostraron que estas metodolog ías son específicas, al no haber interferencias de otros componentes en las señales de los ácidos grasos, ni siquiera al someter previamente los productos a condiciones extremas de degradación. Estas metodologías también resultaron lineales (coeficientes de correlación > 0,99) y exactas (recobrados totales entre 99,6 y 100,3 %) entre el 50 y el 150 % de las masas nominales. La repetibilidad, precisión intermedia y reproducibilidad en las determinaciones presentaron coeficientes de variación < 2,1 %

Body mass index trajectories in young adulthood predict nonâ alcoholic fatty liver disease in middle age: The CARDIA cohort study

Background & AimsNonâ alcoholic fatty liver disease is an epidemic. Identifying modifiable risk factors for nonâ alcoholic fatty liver disease development is essential to design effective prevention programmes. We tested whether 25â year patterns of body mass index change are associated with midlife nonâ alcoholic fatty liver disease.MethodsIn all, 4423 participants from Coronary Artery Risk Development in Young Adults, a prospective populationâ based biracial cohort (age 18â 30), underwent body mass index measurement at baseline (1985â 1986) and 3 or more times over 25 years. At Year 25, 3115 had liver fat assessed by nonâ contrast computed tomography. Nonâ alcoholic fatty liver disease was defined as liver attenuation â ¤40 Hounsfield Units after exclusions. Latent mixture modelling identified 25â year trajectories in body mass index per cent change (%Î ) from baseline.ResultsWe identified four distinct trajectories of BMI%Î : stable (26.2% of cohort, 25â year BMI %Π = 3.1%), moderate increase (46.0%, BMI%Π = 21.7%), high increase (20.9%, BMI%Π = 41.9%) and extreme increase (6.9%, BMI%Π = 65.9%). Y25 nonâ alcoholic fatty liver disease prevalence was higher in groups with greater BMI %Î : 4.1%, 9.3%, 13.0%, and 17.6%, respectively (Pâ trend <.0001). In multivariable analyses, participants with increasing BMI%Î had increasingly greater odds of nonâ alcoholic fatty liver disease compared to the stable group: OR: 3.35 (95% CI: 2.07â 5.42), 7.80 (4.60â 13.23) and 12.68 (6.68â 24.09) for moderate, high and extreme body mass index increase, respectively. Associations were only moderately attenuated when adjusted for baseline or Y25 body mass index.ConclusionsTrajectories of weight gain during young adulthood are associated with greater nonâ alcoholic fatty liver disease prevalence in midlife independent of metabolic covariates and baseline or concurrent body mass index highlighting the importance of weight maintenance throughout adulthood as a target for primary nonâ alcoholic fatty liver disease prevention.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142937/1/liv13603.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142937/2/liv13603_am.pd

Twentyâ fiveâ year trajectories of insulin resistance and pancreatic βâ cell response and diabetes risk in nonalcoholic fatty liver disease

Background & AimsInsulin resistance is a risk marker for nonâ alcoholic fatty liver disease, and a risk factor for liver disease progression. We assessed temporal trajectories of insulin resistance and βâ cell response to serum glucose concentration throughout adulthood and their association with diabetes risk in nonâ alcoholic fatty liver disease.MethodsThree thousand and sixty participants from Coronary Artery Risk Development in Young Adults, a prospective biâ racial cohort of adults age 18â 30 years at baseline (1985â 1986; Y0) who completed up to 5 exams over 25 years and had fasting insulin and glucose measurement were included. At Y25 (2010â 2011), nonâ alcoholic fatty liver disease was assessed by noncontrast computed tomography after exclusion of other liver fat causes. Latent mixture modelling identified 25â year trajectories in homeostatic model assessment insulin resistance and βâ cell response homeostatic model assessmentâ β.ResultsThree distinct trajectories were identified, separately, for homeostatic model assessment insulin resistance (lowâ stable [47%]; moderateâ increasing [42%]; and highâ increasing [12%]) and homeostatic model assessmentâ β (lowâ decreasing [16%]; moderateâ decreasing [63%]; and highâ decreasing [21%]). Y25 nonâ alcoholic fatty liver disease prevalence was 24.5%. Among nonâ alcoholic fatty liver disease, highâ increasing homeostatic model assessment insulin resistance (referent: lowâ stable) was associated with greater prevalent (OR 95% CI = 8.0, 2.0â 31.9) and incident (OR = 10.5, 2.6â 32.8) diabetes after multivariable adjustment including Y0 or Y25 homeostatic model assessment insulin resistance. In contrast, nonâ alcoholic fatty liver disease participants with lowâ decreasing homeostatic model assessmentâ β (referent: highâ decreasing) had the highest odds of prevalent (OR = 14.1, 3.9â 50.9) and incident (OR = 10.3, 2.7â 39.3) diabetes.ConclusionTrajectories of insulin resistance and βâ cell response during young and middle adulthood are robustly associated with diabetes risk in nonâ alcoholic fatty liver disease. Thus, how persons with nonâ alcoholic fatty liver disease develop resistance to insulin provides important information about risk of diabetes in midlife above and beyond degree of insulin resistance at the time of nonâ alcoholic fatty liver disease assessment.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146427/1/liv13747_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146427/2/liv13747.pd