Multilingual Clustering of Streaming News

Clustering news across languages enables efficient media monitoring by aggregating articles from multilingual sources into coherent stories. Doing so in an online setting allows scalable processing of massive news streams. To this end, we describe a novel method for clustering an incoming stream of multilingual documents into monolingual and crosslingual story clusters. Unlike typical clustering approaches that consider a small and known number of labels, we tackle the problem of discovering an ever growing number of cluster labels in an online fashion, using real news datasets in multiple languages. Our method is simple to implement, computationally efficient and produces state-of-the-art results on datasets in German, English and Spanish.Comment: Accepted at EMNLP 201

The SUMMA Platform:A Scalable Infrastructure for Multi-lingual Multi-media Monitoring

The open-source SUMMA Platform is a highly scalable distributed architecture for monitoring a large number of media broadcasts in parallel, with a lag behind actual broadcast time of at most a few minutes. The Platform offers a fully automated media ingestion pipeline capable of recording live broadcasts, detection and transcription of spoken content, translation of all text (original or transcribed) into English, recognition and linking of Named Entities, topic detection, clustering and crosslingual multi-document summarization of related media items, and last but not least, extraction and storage of factual claims in these news items. Browser-based graphical user interfaces provide humans with aggregated information as well as structured access to individual news items stored in the Platform’s database. This paper describes the intended use cases and provides an overview over the system’s implementation

Jointly Extracting and Compressing Documents with Summary State Representations

We present a new neural model for text summarization that first extracts sentences from a document and then compresses them. The proposed model offers a balance that sidesteps the difficulties in abstractive methods while generating more concise summaries than extractive methods. In addition, our model dynamically determines the length of the output summary based on the gold summaries it observes during training and does not require length constraints typical to extractive summarization. The model achieves state-of-the-art results on the CNN/DailyMail and Newsroom datasets, improving over current extractive and abstractive methods. Human evaluations demonstrate that our model generates concise and informative summaries. We also make available a new dataset of oracle compressive summaries derived automatically from the CNN/DailyMail reference summaries

Aconselhamento Genético: Análise e Contribuições a partir do Modelo de Aconselhamento Psicológico

Genetic Counseling (GC) comprises an investigation regarding the diagnosis of genetic diseases. Thus, this case study aimed to analyze a particular GC model. Data collection was conducted through semi-structured interviews and an observation of a GC session. The participants comprised professionals, a biomedical team, and a consultant for a child diagnosed with double Y syndrome. It was observed that GC involves a complex intersubjective relationship and that, in both ends of the relationship (i.e., professional consultants and family members), emotional factors (anxiety, fear, guilty, etc.) and defensiveness (identification, rationalization, etc.) restricted the communication of the diagnosis, preventing the host from effectively explaining such vital information to the inquirer. The GC review process also indicated the following four findings: 1) A dissonance between GC theory and professional actions, 2) A fixation on GC protocol, 3) The use of technical language that made it difficult to communicate, and 4) Insufficient time for considering the chronological dimension. On the basis of the findings, it can be concluded that the GC model could be enriched by the psychological counseling model, especially in relation to crisis management and the vital work of multidisciplinary teams.O Aconselhamento Genético (AG) constitui um processo de investigação do diagnóstico de doenças genéticas. Este estudo de caso objetivou a análise de um modelo de AG. A coleta de dados foi realizada por meio de entrevista semiestruturada e da observação de uma sessão de AG. Os participantes foram profissionais biomédicos e a consulente de uma criança com diagnóstico de síndrome do duplo Y. Verificou-se que o AG envolve uma relação intersubjetiva complexa. Percebeu-se, nos dois polos da relação – profissional e consulente-familiar –, os aspectos emocionais (angústia, temor, culpas etc.) e defensivos (identificação, racionalização etc.) referidos na literatura das crises vitais. A análise do processo de AG indicou: 1) dissonância entre a teoria do AG e a ação do profissional; 2) fixação (defensiva) ao protocolo do AG; 3) uso de linguagem técnica dificultando contato e acolhimento do consulente; e, 4) tempo de compreender considerado na dimensão cronológica e não lógico. Infere-se que os fatores afetivos (angústia, temor, culpas etc.) e a defesa psíquica (identificação, racionalização) restringiram a comunicação do diagnóstico comprometendo o acolhimento e esclarecimento do contexto vital do consulente. Conclui-se que o modelo de AG poderia se enriquecer com a experiência do modelo de aconselhamento psicológico no que se refere ao manejo de crises vitais e no trabalho em equipes multidisciplinares.El Asesoramiento Genético (AG) constituye un proceso de investigación del diagnóstico de enfermedades genéticas. Este estudio de caso tuvo como objetivo analizar un modelo de AG. La colecta de datos fue realizada por medio de entrevista semiestructurada y de la observación de una sesión de AG. Los participantes fueron profesionales biomédicos y el consultante de un niño con diagnóstico de síndrome del doble Y. Se verificó que el AG implica una relación intersubjetiva compleja. Se percibió, en los dos polos de la relación – profesional y consultante – familiar –, los aspectos emocionales (angustia, temor, culpas, etc.) y defensivos (identificación, racionalización etc.) mencionados en la literatura como crisis vitales. El análisis del proceso de AG indicó: 1) disonancia entre la teoría del AG y la acción del profesional; 2) fijación (defensiva) al protocolo del AG, 3) uso de lenguaje técnico dificultando contacto y acogimiento del consultante; e, 4) tiempo de comprender considerado en la dimensión cronológica y no lógica. Se infiere que los factores afectivos (angustia, temor, culpas, etc) y la defensa psíquica (identificación, racionalización) restringieron la comunicación del diagnóstico comprometiendo el acogimiento y aclaratoria del contexto vital del consultante. Se concluye que el modelo de AG podría enriquecerse con la experiencia del modelo de asesoramiento psicológico en lo que se refiere al manejo de crisis vitales y en el trabajo en equipos multidisciplinarios

Influence of leguminous arboreal species in quality and production of Marandu grass (Brachiaria brizantha)

The silvopastures systems promote the production and environment protection, several benefits should to be reached. However, to that benefits result in the tree-grass association, it is necessary that the trees provide, mainly, increase production and quality grass grown below their tops. The objetive was, evaluate the influence of four leguminous arboreal species in seventeen variables of Brachiaria brizantha cv. Marandu growing at different distances (D) from the trunk of leguminous of these trees: D1= 50 cm from the trunk; D2= half of the radius of the projection of the top; D3= the radius of the projection of the top; D4= one and half the radius of the projection of the top ; and D5= twice the radius of the projection of the top. Distances (D4 e D5) corresponding to the areas out of the tops and considered as controls. The used species were Samanea guachapele (albízia), Acacia holosericea (oloserícea), Mimosa tenuiflora (jurema preta) e Mimosa artemisiana (jurema branca). Were evaluates the variables in grass: tenor crude protein , digestibility in vitro of dry matter, neutral detergent fiber, acid detergent fiber, lignin in sulfuric acid, lignin in permanganate of potassium, cellulose, silica and dry matter production. To analyse the datas utilized a multivariate analysis method, the factor analysis. The rotative factor F1, wich explained the highest variance percentage of datas, associated to the results of the factorial scores, showed that the leguminous arboreal specie A. holosericea proporcioned the majors accumulation of dry matter, protein, digestibility in vitro of dry matter in aereal part of Marandu grass, growing in distances more next of the trunk. The rotative factor F1 also showed that the lowest values for these variables were found in grass growing out of the influence of cup is specie Mimosa tenuiflora in the area no tree. The partial results indicate that the arboreal leguminous Acacia holosericea (oloserícea) proportioned the higher quality and quantity in Marandu grass, when it growed under influence of its top

Tofacitinib, un inhibidor oral de la quinasa Janus, para el tratamiento de artritis reumatoide en pacientes de Latinoamérica: eficacia y seguridad de estudios fase 3 y de extensión a largo plazo

Objective: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We assessed tofacitinib efficacy and safety in the Latin American (LA) subpopulation of global Phase 3 and long-term extension (LTE) studies. Materials and methods: Data from LA patients with RA and inadequate response to disease modifying antirheumatic drugs (DMARDs) were pooled across five Phase 3 studies. Phase 3 patients received tofacitinib 5 or 10 mg twice daily (BID), adalimumab or placebo; patients in the single LTE study received tofacitinib 5 or 10 mg BID; treatments were administered alone or with conventional synthetic DMARDs. Efficacy was reported up to 12 months (Phase 3) and 36 months (LTE) by American College of Rheumatology (ACR) 20/50/70 response rates, Disease Activity Score (DAS)28-4(erythrocyte sedimentation rate [ESR]) and Health Assessment Questionnaire-Disability Index (HAQ-DI). Incidence rates (IRs; patients with event/100 patient-years) of adverse events (AEs) of special interest were reported. Results: The Phase 3 studies randomized 496 LA patients; the LTE study enrolled 756 LA patients from Phase 2 and Phase 3. In the Phase 3 studies, patients who received tofacitinib 5 and 10 mg BID showed improvements vs placebo at Month 3 in ACR20 (68.9% and 75.7% vs 35.6%), ACR50 (45.8% and 49.7% vs 20.7%) and ACR70 (17.5% and 23.1% vs 6.9%) responses, mean change from baseline in HAQ-DI (-0.6 and -0.8 vs -0.3) and DAS28-4(ESR) score (-2.3 and -2.4 vs -1.4). The improvements were sustained up to Month 36 in the LTE study. In the Phase 3 studies, IRs with tofacitinib 5 and 10 mg BID and placebo were 7.99, 6.57 and 9.84, respectively, for SAES, and 3.87, 5.28 and 3.26 for discontinuation due to AEs. IRs of AEs of special interest in tofacitinib-treated LA patients were similar to the global population. Conclusion: In Phase 3 and LTE studies in LA patients with RA, tofacitinib demonstrated efficacy up to 36 months with a manageable safety profile up to 60 months, consistent with the overall tofacitinib study population.Objetivo: Tofacitinib es un inhibidor oral de la quinasa Janus para el tratamiento de la artritis reumatoide (AR). Este análisis evaluó la eficacia y la seguridad de tofacitinib en la subpoblación Latinoamericana (LA) de los estudios fase 3 y de extensión a largo plazo (ELP). Materiales y métodos: Se agruparon datos de pacientes de Latinoamérica con AR y una respuesta inadecuada a agentes modificadores de la enfermedad (DMARD) de 5 estudios fase 3. Los pacientes en estos estudios recibieron tofacitinib 5 o 10 mg/2 veces al día (bid), adalimumab o placebo; los pacientes en el estudio de seguridad recibieron tofacitinib 5 o 10 mg/bid; los tratamientos se administraron en monoterapia o con DMARD sintéticos convencionales. La eficacia se reporta hasta 12 (fase 3) y 36 meses (ELP) mediante las tasas de respuesta del Colegio Americano de Reumatología (ACR) 20/50/70, el índice de actividad de la enfermedad (DAS)28-4 ESR (tasa de sedimentación globular [ESR]) y el índice de discapacidad del cuestionario de evaluación de la salud (HAQ-DI). Se reportan las tasas de incidencia (IR: pacientes con evento/100 pacientes/a˜no) de eventos adversos (EA) de interés especial. Resultados: Los estudios fase 3, incluyeron 496 pacientes de LA, el ELP reclutó 756 pacientes de fase 2 y fase 3. En los estudios de fase 3, los pacientes que recibieron tofacitinib 5 y 10 mg/bid presentaron mejorías vs placebo al mes 3 en las respuestas ACR20 (68,9% y 75,7% vs 35,6%), ACR50 (45,8% y 49,7% vs 20,7%) y ACR70 (17,5% y 23,1% vs 6,9%), en cambio, desde el valor basal en el escore HAQ-DI (−0,6 y −0,8 vs −0,3) y en el escore DAS28-4(ESR) (−2,3 y −2,4 vs −1,4); estas mejorías fueron sostenidas hasta el mes 36, último mes de evaluación en el estudio de ELP. En los pacientes con tofacitinib 5 o 10 mg/bid y placebo, las tasas de incidencia de SAE fueron de 7,99, 6,57 y 9,84, mientras que la incidencia de descontinuaciones por EA fueron de 3,87, 5,28 y 3,26, respectivamente. Las IR de EA de interés especial en pacientes de LA fueron similares a la población global. Conclusión: En los pacientes de LA con AR de estudios fase 3 y ELP, tofacitinib demostró eficacia hasta por 36 meses con un perfil de seguridad manejable hasta por 60 meses, en los pacientes de LA con AR, datos consistentes con el de la población global de los estudios de tofacitinib.Pfizer Inc