48 research outputs found
Time evolution of deformation in a human cartilage under cyclic loading
Recent imaging has revealed that in vivo contact deformations of human knee cartilage under physiological loadings are surprisingly large—typically on the order of 10%, but up to 20 or 30% of tibiofemora cartilage thickness depending on loading conditions. In this paper we develop a biphasic, large deformation, non-linear poroelastic model of cartilage that can accurately represent the time dependence and magnitude of cyclic cartilage deformations in vivo. The model takes into account cartilage tension–compression nonlinearity and a new constitutive relation in which the compressive stiffness and hydraulic permeability of the cartilage adjusts in response to the strain-dependent aggrecan concentration. The model predictions are validated using experimental test results on osteochondral plugs obtained from human cadavers. We find that model parameters can be optimised to give an excellent fit to the experimental data. Using typical hydraulic conductivity and stiffness parameters for healthy cartilage, we find that the experimentally observed transient and steady state tissue deformations under cyclic loading and unloading can be reproduced by the model. Steady state tissue deformations are shown to cycle between 10% (exudation strain) and 20% (total strain) in response to the cyclic test loads. At steady-state cyclic loading, the pore fluid exuded from the tissue is exactly equal to the pore fluid imbibed by the tissue during each load cycle
Osteoporotic bone fracture healing under the locking compression plate system
Abstract Osteoporosis is highly prevalent and a costly disease predicted to affect 1,555 million worldwide by 2050, and the total cost of osteoporotic fractures worldwide could reach US$131 billion by 2025. These statistics clearly affirm the significant economic burden of osteoporotic fractures to the community, and the need for the development of improved fracture treatments. Studies over the last decade reveal that, even though osteoporosis may not necessarily lead to non-union, it is associated with delayed fracture healing due to impaired mecho-regulation and angiogenesis in osteoporotic condition. Despite the advances in locking compression plate (LCP) technology, the operative treatment in osteoporotic fractures remains a challenge for an orthopaedic surgeon, often with unpredictable outcomes. Therefore, it becomes necessary to bridge the 'information gap' between osteoporosis and its effect on fracture healing, and so enables healing progression prediction under different fracture geometries and fixation configurations. By using a computational model of fracture healing, this paper demonstrates that fracture healing can be significantly delayed due to impaired mechano-regulation as a result of osteoporosis, and the impact of osteoporosis on fracture healing can be mitigated by adjusting the configuration of the LCP system to allow a certain degree of interfragmentary movement (IFM) without compromising overall fixation stability
Computational modelling of the mechanical environment of the early stage of fracture healing using structural engineering techniques
Bone healing is a complex biological process which is regulated by mechanical micro-environment
caused by inter-fragmentary movement (IFM). IFM generated interstitial fluid flow within the fracture
callus could potentially not only affect the mesenchymal stem cells migration and differentiation
during the healing, but also enhance nutrient transport within the callus tissue.
In this study, a three dimensional poroelastic finite element model of a human tibia was developed to
study the mechanical behaviour of the fracture callus due to IFM at the early stage of fracture. The
biophysical stimuli were characterised with three main parameters involved in the healing process:
octahedral shear strain, interstitial fluid velocity and pressure. The proposed algorithm represents a
first step towards to the development of a powerful simulation tool for fracture healing
Computational modelling of bone fracture healing using the theory of porous media
© 2014 Dr. Seyedsaeed MiraminiOptimal bone fracture healing requires understanding of the fundamental relationship between the stability of fracture fixation and the biomechanical microenvironment of callus cells at the fracture site. However, this relationship is still not fully understood. In this research, a validated computational model of fracture healing is developed to predict the tissue differentiation pattern in soft fracture callus in the early stage of healing as a result of callus cells responding to the change of their biomechanical microenvironment under different configurations of locking plate fixation (e.g. the plate working length (WL), the bone-plate distance (BPD) and type of locking screw) and various geometries of fracture site (e.g. fracture gap size and angle of obliquity). The model is developed based on the Theory of Porous Media with consideration of the large deformation of soft fracture callus in conjunction with mechanical testing and the advanced techniques of 3D geometry reconstruction of fractured bone from CT scan images (Miramini et al., 2013, Miramini et al., 2014).
The results of this study suggest that, for a small fracture gap size (e.g. 1mm), a relatively flexible configuration of locking plate fixation achieved by the increase of the WL and BPD may result in excessive biomechanical stimuli and so leading to excessive fibrous tissue differentiation, whereas increasing flexibility of locking plate fixation could have beneficial effect on relatively large gap size (e.g. 3mm) through enhancing the formation of fracture callus.
In addition, the model results suggest that, when locking plate is used with dynamic locking screws (DLS), there is an optimal fixation stiffness modulated by the locking plate and the DLS. A higher bending stiffness of locking plate in combination with DLS can lead to a more uniform interfragmentary movement across the fracture site which could result in better healing outcomes.
The role of fracture geometry (i.e. angle of obliquity and fracture gap size) on bone healing under locking plate fixation is also investigated in this study. The results show that oblique fractures with large angles of obliquity (i.e. θ≥45°) could result in the callus tissue at the near cortex being under tension. The shear interfragmentary movement is also seen to significantly increase with fracture obliquity. Most importantly, the biomechanical stimuli in the fracture site of an oblique fracture stabilized by locking plate fixation are shown to be relatively lower in comparison to that of a transverse fracture. The research outcomes also demonstrate that, for an oblique fracture with large gap size, increasing the flexibility of locking plate fixation could potentially enhance callus formation and thereby improve the healing outcomes.
In summary, this thesis presents a state-of-the-art computational model of fracture healing which could potentially be used by orthopaedic surgeons for designing a better patient specific surgical treatment strategy
The spatio-temporal mechanical environment of healthy and injured human cartilage during sustained activity and its role in cartilage damage
Recently we presented a computational model of articular cartilage calibrated for normal human tissue explants. This model was able to capture the transient deformation of cartilage experiencing a cyclic load. The model takes into account the tension-compression nonlinearity of the cartilage and incorporates the dependency of the compressive stiffness and fluid permeability of cartilage on the deformation-dependent aggrecan concentration in cartilage tissue. As such it represents a leading constitutive model of articular cartilage. Here we build on the previous study to develop an experimentally validated computational model to simulate mechanical consolidation response of intact and previously injured cartilage under sustained static loading, to develop our understanding of the implications for rates of tissue damage. We see that the type of prior injuries compromise the cartilage function in different ways. Relatively rapid consolidation is predicted for cartilage with a complete meniscectomy and that with a full thickness defect, indicating the inability of cartilage with such injuries to sustain interstitial fluid pressurisation for long periods of time, as does uninjured cartilage. By comparing the consolidation response of articular cartilage predicted by computational model against experimental measurements of the apparent friction coefficient following static loading, we find a strong linear positive correlation exists between cartilage degree of consolidation (DoC) and friction coefficient at the joint. As the DoC of articular cartilages can be estimated in vivo via medical imaging, the DoC can be used as an index to non-invasively evaluate the apparent friction coefficient between opposing cartilage surfaces, and so estimate the likelihood of frictional surface wear and/or cartilage damag
Investigation of role of cartilage surface polymer brush border in lubrication of biological joints
Although experimental evidence has suggested that the polymer brush border (PBB) on the cartilage surface is important in regulating fluid permeability in the contact gap, the current theoretical understanding of joint lubrication is still limited. To address this research gap, a multiscale cartilage contact model that includes PBB, in particular its effect on the fluid permeability of the contact gap, is developed in this study. Microscale modeling is employed to estimate the permeability of the contact gap. This permeability is classified into two categories: For a gap size > 1 µm, the flow resistance is assumed to be dominated by the cartilage roughness; for gap size < 1 µm, flow resistance is assumed to be dominated by the surface polymers extending beyond the collagen network of the articular cartilage. For gap sizes of less than 1 µm, the gap permeability decreases exponentially with increasing aggrecan concentration, whereas the aggrecan concentration varies inversely with the gap size. Subsequently, the gap permeability is employed in a macroscale cartilage contact model, in which both the contact gap space and articular cartilage are modeled as two interacting poroelastic systems. The fluid exchange between these two media is achieved by imposing pressure and normal flux continuity boundary conditions. The model results suggest that PBB can substantially enhance cartilage lubrication by increasing the gap fluid load support (e.g., by 26 times after a 20-min indentation compared with the test model without a PBB). Additionally, the fluid flow resistance of PBB sustains the cartilage interstitial fluid pressure for a relatively long period, and hence reduces the vertical deformation of the tissue. Furthermore, it can be inferred that a reduction in the PBB thickness impairs cartilage lubrication ability
A coupled contact model of cartilage lubrication in the mixed-mode regime under static compression
This study presents a coupled cartilage contact model, in which the contact gap and cartilage tissue are modelled as two poroelastic systems, linked by pressure and normal flux continuity boundary conditions. Using a tibial plug under indentation as a proof-of-concept model, the predictions support the weeping lubrication theory under static compression. Specifically, the interstitial fluid would exude from the underlying cartilage into the contact gap to extend the mixed-mode duration by > 20-fold compared to a no fluid exudation counterpart. Moreover, the traditional contact model, that does not consider the contact gap and cartilage fluid exchange, potentially overestimates the interstitial fluid pressure compared to the proposed coupled model. Parametric studies suggest that the increasing viscosity of synovial fluid prolongs the gap fluid pressurisation, while increasing the asperity stiffness reduces the gap fluid pressure but increases contact gap height
Computational study on synovial fluid flow behaviour in cartilage contact gap under osteoarthritic condition
This study numerically investigates the pathological changes of fluid flow in cartilage contact gap due to the changes in cartilage surface roughness and synovial fluid characteristics in osteoarthritic (OA) condition. First, cartilage surface topographies in both healthy and OA conditions are constructed using a numerical approach with consideration of both vertical and horizontal roughness. Then, constitutive equations for synovial fluid viscosity are obtained through calibration against previous experimental data. Finally, the roughness and synovial fluid information are input into the gap flow model to predict the gap permeability. The results show that the rougher surface of OA cartilage tends to decrease gap permeability by around 30%–60%. More importantly, with the reduction in gap size, the decrease in gap permeability becomes more significant, which could result in an early fluid ultrafiltration into the tissue. Moreover, it is demonstrated that the pathological synovial fluid has more deleterious effects on the gap permeability than the OA cartilage surface, as it could potentially increase the gap permeability by a few hundred times for pressure gradients less than 106 Pa/m, which could inhibit the fluid ultrafiltration into the tissue. The outcomes from this research indicate that the change in fluid flow behaviour in contact gap in OA condition could significantly affect the function of articular joints