1,159 research outputs found

    Phase diagram and surface tension in the three-flavor Polyakov-quark-meson model

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    We obtain the in-medium effective potential of the three-flavor Polyakov-Quark-Meson model as a real function of real variables in the Polyakov loop variable, to allow for the study of all possible minima of the model. At finite quark chemical potential, the real and imaginary parts of the effective potential, in terms of the Polyakov loop variables, are made apparent, showing explicitly the fermion sign problem of the theory. The phase diagram and other equilibrium observables, obtained from the real part of the effective potential, are calculated in the mean-field approximation. The obtained results are compared to those found with the so-called saddle-point approach. Our procedure also allows the calculation of the surface tension between the chirally broken and confined phase, and the chirally restored and deconfined phase. The values of surface tension we find for low temperatures are very close to the ones recently found for two-flavor chiral models. Some consequences of our results for the early Universe, for heavy-ion collisions, and for proto-neutron stars are briefly discussed.Comment: 17 pages, 6 figures. V2: typos fixed, references adde

    Some remarks on the spectral functions of the Abelian Higgs Model

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    We consider the unitary Abelian Higgs model and investigate its spectral functions at one-loop order. This analysis allows to disentangle what is physical and what is not at the level of the elementary particle propagators, in conjunction with the Nielsen identities. We highlight the role of the tadpole graphs and the gauge choices to get sensible results. We also introduce an Abelian Curci-Ferrari action coupled to a scalar field to model a massive photon which, like the non-Abelian Curci-Ferarri model, is left invariant by a modified non-nilpotent BRST symmetry. We clearly illustrate its non-unitary nature directly from the spectral function viewpoint. This provides a functional analogue of the Ojima observation in the canonical formalism: there are ghost states with nonzero norm in the BRST-invariant states of the Curci-Ferrari model.Comment: 32 pages, 12 figure

    Serial intravascular ultrasound assessment of changes in coronary atherosclerotic plaque dimensions and composition: an update

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    This manuscript reviews the use of serial intravascular ultrasound (IVUS) examination of coronary atherosclerosis in recent observational studies and randomized trials that revealed the effects of cholesterol-lowering and lipid-modifying therapies and offered novel insight into plaque progression and regression. We discuss the value of plaque progression–regression as complementary imaging endpoint and potential surrogate marker of cardiovascular event risk. In addition, the progress in serial assessment of coronary plaque composition and plaque vulnerability by radiofrequency-based analyses is reviewed. Finally, we report on the evaluation of true vessel remodelling in recent serial IVUS trials and discuss the future perspective of serial invasive imaging of coronary atherosclerosis

    Intracoronary imaging guided percutaneous coronary intervention outcomes among individuals with cardiogenic shock

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    BACKGROUND: Limited data exist around the utility of intracoronary imaging (ICI) during percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and cardiogenic shock (CS), who are inherently at a high risk of stent thrombosis (ST). METHODS: All PCI procedures for ACS patients with CS in England and Wales between 2014 and 2020 were retrospectively analysed, stratified into two groups: ICI and angiography-guided groups. Multivariable logistic regression analyses were performed to examine odds ratios (OR) of in-hospital outcomes, including major adverse cardiovascular and cerebrovascular events (MACCE; composite of all-cause mortality, acute stroke/transient ischaemic attack (TIA), and reinfarction) and major bleeding, in the ICI-guided group compared with angiography-guided PCI. RESULTS: Of 15,738 PCI procedures, 1240(7.9%) were ICI-guided. The rate of ICI use amongst those with CS more than doubled from 2014 (5.7%) to 2020 (13.3%). The ICI-guided group were predominantly younger, males, with a higher proportion of non-ST-elevation ACS and ST. MACCE was significantly lower in the ICI-guided group compared with the angiography-guided group (crude: 29.8% vs. 38.2%, adjusted odds ratio (OR) 0.65 95% confidence interval [CI] 0.56-0.76), driven by lower all-cause mortality (28.6% vs. 37.0%, OR 0.65 95% CI 0.55-0.75). There were no differences in other secondary outcomes between groups. CONCLUSION: ICI use among CS patients has more than doubled over 6 years but remains significantly under-utilized, with less than 1-in-6 patients in receipt of ICI-guided PCI by 2020. ICI-guided PCI is associated with prognostic benefits in CS patients and should be more frequently utilized to increase their long-term survival
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