651 research outputs found

    Morning Address, Part 2: UC San Diego Curation Pilots: Planning for the Future

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    David Minor, MA, is Director of Digital Preservation Initiatives and Chronopolis Program Manager, University of California, San Diego Library. This presentation provided an overview of the 5 pilot projects in UC San Diego\u27s data curation pilot program, including findings, recommendations, and implementation

    Preparation for meaningful work and life: urban high school youth's reflections on work-based learning 1 year post-graduation

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    The challenges confronted by low-income high school students throughout school and across the transition to higher education and employment are well-documented in the US and many other nations. Adopting a positive youth development perspective (Lerner et al., 2005), this study reports findings from interviews with 18 low-income, racially and ethnically diverse graduates of an urban Catholic high school in the US. The interviews were designed to shed light on the post-high school experiences of urban high school graduates and to understand how students construct meaning about the value of school and work-based learning (WBL) in their preparation for meaningful work and life. The interviews highlight the perceived value of the academic and non-cognitive preparation students experienced through high school and WBL in relation to the challenges they encountered along the pathway to post-high school success and decent work. Overall, the findings suggest the potential of WBL for low-income youth in facilitating access to resources that build academic and psychological/non-cognitive assets, while also illustrating the role of structural and contextual factors in shaping post-high school transitions and access to meaningful work and life opportunities.Published versio

    Curation Micro-Services: A Pipeline Metaphor for Repositories

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    The effective long-term curation of digital content requires expert analysis, policy setting, and decision making, and a robust technical infrastructure that can effect and enforce curation policies and implement appropriate curation activities. Since the number, size, and diversity of content under curation management will undoubtedly continue to grow over time, and the state of curation understanding and best practices relative to that content will undergo a similar constant evolution, one of the overarching design goals of a sustainable curation infrastructure is flexibility. In order to provide the necessary flexibility of deployment and configuration in the face of potentially disruptive changes in technology, institutional mission, and user expectation, a useful design metaphor is provided by the Unix pipeline, in which complex behavior is an emergent property of the coordinated action of a number of simple independent components. The decomposition of repository function into a highly granular and orthogonal set of independent but interoperable micro-services is consistent with the principles of prudent engineering practice. Since each micro-service is small and self-contained, they are individually more robust and collectively easier to implement and maintain. By being freely interoperable in various strategic combinations, any number of micro-services-based repositories can be easily constructed to meet specific administrative or technical needs. Importantly, since these repositories are purposefully built from policy neutral and protocol and platform independent components to provide the function minimally necessary for a specific context, they are not constrained to conform to an infrastructural monoculture of prepackaged repository solutions. The University of California Curation Center has developed an open source micro-services infrastructure that is being used to manage the diverse digital collections of the ten campus University system and a number of non-university content partners. This paper provides a review of the conceptual design and technical implementation of this micro-services environment, a case study of initial deployment, and a look at ongoing micro-services developments

    Coiled Coils Direct Assembly of a Cold-Activated TRP Channel

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    SummaryTransient receptor potential (TRP) channels mediate numerous sensory transduction processes and are thought to function as tetramers. TRP channel physiology is well studied; however, comparatively little is understood regarding TRP channel assembly. Here, we identify an autonomously folded assembly domain from the cold- and menthol-gated channel TRPM8. We show that the TRPM8 cytoplasmic C-terminal domain contains a coiled coil that is necessary for channel assembly and sufficient for tetramer formation. Cell biological experiments indicate that coiled-coil formation is required for proper channel maturation and trafficking and that the coiled-coil domain alone can act as a dominant-negative inhibitor of functional channel expression. Our data define an authentic TRP modular assembly domain, establish a clear role for coiled coils in ion channel assembly, demonstrate that coiled-coil assembly domains are a general feature of TRPM channels, and delineate a new tool that should be of general use in dissecting TRPM channel function

    Curation Micro-Services: A Pipeline Metaphor for Repositories

    Get PDF
    The effective long-term curation of digital content requires expert analysis, policy setting, and decision making, and a robust technical infrastructure that can effect and enforce curation policies and implement appropriate curation activities. Since the number, size, and diversity of content under curation management will undoubtedly continue to grow over time, and the state of curation understanding and best practices relative to that content will undergo a similar constant evolution, one of the overarching design goals of a sustainable curation infrastructure is flexibility. In order to provide the necessary flexibility of deployment and configuration in the face of potentially disruptive changes in technology, institutional mission, and user expectation, a useful design metaphor is provided by the Unix pipeline, in which complex behavior is an emergent property of the coordinated action of a number of simple independent components. The decomposition of repository function into a highly granular and orthogonal set of independent but interoperable micro-services is consistent with the principles of prudent engineering practice. Since each micro-service is small and self-contained, they are individually more robust and collectively easier to implement and maintain. By being freely interoperable in various strategic combinations, any number of micro-services-based repositories can be easily constructed to meet specific administrative or technical needs. Importantly, since these repositories are purposefully built from policy neutral and protocol and platform independent components to provide the function minimally necessary for a specific context, they are not constrained to conform to an infrastructural monoculture of prepackaged repository solutions. The University of California Curation Center has developed an open source micro-services infrastructure that is being used to manage the diverse digital collections of the ten campus University system and a number of non-university content partners. This paper provides a review of the conceptual design and technical implementation of this micro-services environment, a case study of initial deployment, and a look at ongoing micro-services developments

    Comparison of the Hindin Proteins of Strongylocentrotus franciscanus, S. purpuratus, and Lytechinus variegatus: Sequences involved in the Species Specificity of Fertilization

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    Bindin is the sea urchin sperm acrosomal protein that is responsible for the species-specific adhesion of the sperm to the egg. Two new bindin cDNA sequences that contain the entire open reading frame for the binding precursor are reported: one for Strongylocentrotus franciscanus and one for Lytechinus variegatus. Both contain inverted repetitive sequences in their 3' untranslated regions, and the S. franciscanus cDNA contains an inverted repetitive sequence match between the 5' untranslated region and the coding region. The middle third of the mature bindin sequence is highly conserved in all three species, and the flanking sequences share short repeated sequences that vary in number between the species. Cross-fertilization data are reported for the species S. purpuratus, S. franciscanus, L. variegatus, and L. pictus. A barrier to cross-fertilization exists between the sympatric Strongylocentrotus species, but there is no barrier between the allopatric Lytechinus species

    Kentucky Probationers\u27 and Parolees\u27 Perceptions of the Severity of Prison versus County Jail and Probation

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    This study extends a growing body of research on offenders\u27 perceptions of the punitiveness of criminal sanctions. Specifically, we examine punishment equivalency ratings by Kentucky probationers and parolees (N-588) meant to gauge their perceptions of the severity of prison compared to both probation and county jail. Ratings are analyzed by several demographic characteristics. We find that, in general, survey respondents pereceived county jail as more severe than prison but that probation was rated as less severe

    Inferring transportation mode from smartphone sensors:Evaluating the potential of Wi-Fi and Bluetooth

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    Understanding which transportation modes people use is critical for smart cities and planners to better serve their citizens. We show that using information from pervasive Wi-Fi access points and Bluetooth devices can enhance GPS and geographic information to improve transportation detection on smartphones. Wi-Fi information also improves the identification of transportation mode and helps conserve battery since it is already collected by most mobile phones. Our approach uses a machine learning approach to determine the mode from pre-prepocessed data. This approach yields an overall accuracy of 89% and average F1 score of 83% for inferring the three grouped modes of self-powered, car-based, and public transportation. When broken out by individual modes, Wi-Fi features improve detection accuracy of bus trips, train travel, and driving compared to GPS features alone and can substitute for GIS features without decreasing performance. Our results suggest that Wi-Fi and Bluetooth can be useful in urban transportation research, for example by improving mobile travel surveys and urban sensing applications
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