The legend of Blind Maks as the basis for developing a new tourist product of Łódź

The article is an attempt of presenting the possibilities of placing the real facts and the characters from Bałuty district in Łódź taken from Polish Interwar Period in the tourism. The “career” of Menachem Bornsztajn is taken into account in the analysis. In the region of Łódź he was known as “Slepy Maks”. Despite his enormous “fame”, he is an unknown character among the society of Stare Bałuty district, where he grew up. It is confirmed by survey research carried out among citizens of Stare Bałuty. The trust is that there are particular episodes related to that character, however they are not forming the coherent touristic product. The main purpose of this article is to show how the hidden potential of the story about Slepy Maks can be used to create a new, competitive touristic product of the city. Artykuł jest próbą zaprezentowania możliwości wykorzystania w turystyce oryginalnych wydarzeń i postaci łódzkich Bałut z okresu 20-lecia międzywojennego. Do analiz wybrano „karierę” Menachema Bornsztajna znanego w łódzkim półświatku jako Ślepy Maks. Pomimo jego ogromnej „sławy” jest on dzisiaj postacią nieznaną nawet wśród mieszkańców Starych Bałut, na których się wychował. Potwierdzają to przeprowadzone badania ankietowe wśród osób zamieszkujących tę dzielnicę. Istnieją co prawda pojedyncze wydarzenia związane z tą postacią, jednak nie tworzą one spójnego produktu turystycznego. Głównym celem artykułu jest wskazanie, w jaki sposób potencjał związany z postacią Ślepego Maksa mógłby być wykorzystany do wykreowania nowego, konkurencyjnego produktu turystycznego miasta.

Sport impact on patients with psoriasis and psychiatric problems

Introduction: Psoriasis is a systemic inflammatory disease with an immunological basis. The estimated number of people suffering from psoriasis is 60 million. Despite the large number of patients with this diagnosis, the question of which mechanisms are mainly responsible for its development has not yet been answered. One theory is that a change in the patient's psychological state acts as a trigger for the manifestation and worsening of the disease. Another unresolved issue is the relationship between sports and psoriasis. While some studies suggest exercise might worsen symptoms, others highlight potential benefits like improved quality of life. Aim of the study : The aim of our study is to present connection between mental state of patients and occurance of psoriasis.  Additionally, the study aims to elucidate the potential benefits of integrating psychological interventions and physical activity into psoriasis management strategies, with the goal of improving patient outcomes and enhancing overall quality of life. Material and methods : We searched electronic databases, using keywords such as „Psoriasis”, „Depression” and „Psoriasis and sport ”. Conclusions : Psoriasis stands as a profound example of the intricate interplay between physical health and mental well-being. The findings presented in this paper underscore the importance of a holistic approach to psoriasis management, integrating dermatological, psychological, and physical interventions

Correlation between depression, physical exercise and neurodegenerative diseases

Introduction: Depression is the most common mental disorder, affecting a significant percentage of the adult population. The disease is associated with many negative health consequences and is one of the leading causes of disability and inability to work worldwide. This neurological condition is commonly associated with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). In recent decades, advancements have uncovered certain pathophysiological and molecular mechanisms underlying these disorders. These revelations suggest that, although they exhibit unique characteristics, there are notable parallels in the neurobiological changes associated with major depressive disorder (MDD) and the neurodegenerative processes in Alzheimer's disease, Parkinson's disease, and Huntington's disease. In this article the relevance of non-pharmacological therapies in the management of neurodegenerative diseases have been rising. Almost absent from side effects, non-pharmacological alternatives, including physical exercise have shown promising benefits. Aim of the study: The study aims to evaluate the association between depression symptoms and neurodegenerative diseases. Moreover, we indicate sport as a way to preserve and improve cognitive function, and to maintain a proper quality of life. Material and methods: We conducted a review of scientific publications published in the years 1998-2024 in English and Polish in the PubMed and Google Scholar databases. We used keywords such as "depression", "neurodegeneration” and “physical exercise”. Conclusions: Depression has been demonstrated to be a risk factor for neurodegenerative diseases and suggested to be a possible prodrome for them. However, sport can alleviate behavioral symptoms in neurodevelopmental disorders, like anxiety, depression, indifference and sleep disruptions

Prevalence of monogenic diabetes amongst Polish children after a nationwide genetic screening campaign

Aims/hypothesis The aim of this study was to study dynamic changes in the prevalence of different types of diabetes in paediatric populations in Poland, with a specific focus on monogenic diabetes (MD). Methods Using epidemiologic data (PolPeDiab Collaboration) and nationwide genetic test results (TEAM Programme), we compared the prevalence of type 1, type 2 and cystic fibrosis-related diabetes (CFRD) and MD. Genetically confirmed MD included MODY, neonatal diabetes and Wolfram and Alström syndromes. The study covered all children aged 0-18 years treated for diabetes between 2005 and 2011 in three regions, inhabited by 23.7% (1,989,988) of Polish children, with a low prevalence of childhood obesity (<5%). Results The prevalence of type 1 diabetes showed a continuous increase, from 96 to 138/100,000 children. The prevalence of type 2 diabetes and CFRD also increased, from 0.3 to 1.01/100,000 children and from 0.1 to 0.95/100,000 children, respectively. The prevalence of MD was stable at between 4.2 and 4.6/100,000 children, accounting for 3.1-4.2% of children with diabetes, with glucokinase (GCK)-MODY being the most frequent type, amounting to 83% of patients with MD. The percentage of positive test results decreased with the number of referrals, suggesting that children with the highest probability of MD were referred initially, followed by those with a less clear-cut phenotype. The prevalence of neonatal diabetes equalled 1 in 300,000 children. Conclusions/interpretation The prevalence of MD in a paediatric population with a low prevalence of obesity remains stable and is nearly fivefold higher than that of type 2 diabetes and CFRD, justifying a need for increased access to genetic diagnostic procedures in diabetic children

The role of physical exercise in diseases treated with colchicine - an ancient drug with novel clinical applications

Colchicine, a lipid-soluble alkaloid derived from Colchicum autumnale, has a long history of use dating back to ancient Egypt. Traditionally used to alleviate pain and swelling, colchicine is now administered for various diseases, including gout and Familial Mediterranean Fever (FMF). Recent studies have expanded its applications to atherosclerotic cardiovascular diseases, such as acute coronary syndromes and COVID-19. This review aims to summarize the diverse clinical applications of colchicine, with a particular focus on its role in athletes and the synergistic effects of physical exercise in these conditions. Colchicine exhibits broad anti-inflammatory effects primarily by disrupting microtubule functions, which impairs neutrophil migration and reduces cytokine production. Despite its narrow therapeutic window and potential for drug interactions, colchicine is considered safe and effective for managing conditions like gout, FMF, and acute coronary syndromes. Physical exercise complements colchicine treatment by enhancing symptom control and disease management. However, the role of colchicine in COVID-19 treatment remains inconclusive, necessitating further research

Correlation between depression, physical exercise and neurodegenerative diseases

Introduction: Depression is the most common mental disorder, affecting a significant percentage of the adult population. The disease is associated with many negative health consequences and is one of the leading causes of disability and inability to work worldwide. This neurological condition is commonly associated with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). In recent decades, advancements have uncovered certain pathophysiological and molecular mechanisms underlying these disorders. These revelations suggest that, although they exhibit unique characteristics, there are notable parallels in the neurobiological changes associated with major depressive disorder (MDD) and the neurodegenerative processes in Alzheimer's disease, Parkinson's disease, and Huntington's disease. In this article the relevance of non-pharmacological therapies in the management of neurodegenerative diseases have been rising. Almost absent from side effects, non-pharmacological alternatives, including physical exercise have shown promising benefits. Aim of the study: The study aims to evaluate the association between depression symptoms and neurodegenerative diseases. Moreover, we indicate sport as a way to preserve and improve cognitive function, and to maintain a proper quality of life. Material and methods: We conducted a review of scientific publications published in the years 1998-2024 in English and Polish in the PubMed and Google Scholar databases. We used keywords such as "depression", "neurodegeneration” and “physical exercise”. Conclusions: Depression has been demonstrated to be a risk factor for neurodegenerative diseases and suggested to be a possible prodrome for them. However, sport can alleviate behavioral symptoms in neurodevelopmental disorders, like anxiety, depression, indifference and sleep disruptions

Prevalence of monogenic diabetes amongst Polish children after a nationwide genetic screening campaign

AIMS/HYPOTHESIS: The aim of this study was to study dynamic changes in the prevalence of different types of diabetes in paediatric populations in Poland, with a specific focus on monogenic diabetes (MD). METHODS: Using epidemiologic data (PolPeDiab Collaboration) and nationwide genetic test results (TEAM Programme), we compared the prevalence of type 1, type 2 and cystic fibrosis-related diabetes (CFRD) and MD. Genetically confirmed MD included MODY, neonatal diabetes and Wolfram and Alström syndromes. The study covered all children aged 0–18 years treated for diabetes between 2005 and 2011 in three regions, inhabited by 23.7% (1,989,988) of Polish children, with a low prevalence of childhood obesity (<5%). RESULTS: The prevalence of type 1 diabetes showed a continuous increase, from 96 to 138/100,000 children. The prevalence of type 2 diabetes and CFRD also increased, from 0.3 to 1.01/100,000 children and from 0.1 to 0.95/100,000 children, respectively. The prevalence of MD was stable at between 4.2 and 4.6/100,000 children, accounting for 3.1–4.2% of children with diabetes, with glucokinase (GCK)-MODY being the most frequent type, amounting to 83% of patients with MD. The percentage of positive test results decreased with the number of referrals, suggesting that children with the highest probability of MD were referred initially, followed by those with a less clear-cut phenotype. The prevalence of neonatal diabetes equalled 1 in 300,000 children. CONCLUSIONS/INTERPRETATION: The prevalence of MD in a paediatric population with a low prevalence of obesity remains stable and is nearly fivefold higher than that of type 2 diabetes and CFRD, justifying a need for increased access to genetic diagnostic procedures in diabetic children. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00125-012-2621-2) contains peer-reviewed but unedited supplementary material, which is available to authorised users

Synthesis of thiouronium salt with usind a green chemistry method

Celem mojej pracy była synteza soli tiouroniowych bez użycia rozpuszczalników a następnie krystalizacja ich z odpowiednio dobranych rozpuszczalników. Dla wszystkich związków zarejestrowano widma 1H NMR oraz 13C NMR. Jede związek poddano hydrolizie i zamieszczono dla niego chromatogram.The purpose of my study was tiouroniowych salt synthesis without solvent followed by crystallization of the solvent appropriately selected. For all the compounds of the 1H NMR spectrum was recorded and 13C NMR. Jede compound was hydrolyzed and forth to the chromatogram