The Dilemma of Old, Urban Neighborhoods

In his recounting of the suburban migration from America\u27s cities, journalist and broadcaster Ray Suarez laments the loss of the old neighborhood . He extols its virtues while explaining its decline. Suarez\u27s nostalgic examples recall the virtues of the extended family kinship, neighborliness, and other features of the urban village. These are often associated with those urban neighborhoods populated by recent immigratns. These urban villages were thought to have peaked in the decades between the American Civil War and the onset of the First World War, when many U.S. cities industrialized and grew very rapidly. However, a continuing movement of migrants from the southern United States, Puerto RIco, and during the past few decades from around the globe has meant the survival of the urban village in many cities. Like their earlier predecessors, these neighborhoods are often characterized by high rates of poverty and substandard social conditions. In contrast to the old urban neighborhoods populated by the new immigratns, many neighborhoods in the economically and socially distressed areas of U.S. cities have been largely depopulated and have abnormally high rates of abandonment and social problems. These neighborhoods are often highly segregated by race and ethnicity and have high concentrations of poverty. Old urban neighborhoods have been a focus of social policy for the past fifty years. The passage of the Housing Act of 1949 heralded a federal commitment, at least on a limited basis, to provide the public housing for the poor and decent neighborhoods for those living in the slums through urban redevelopment, later renamed urban renewal. In the ensuing five decades, various federal policies and programs have been inaugerated, some later to be either reformed or dismantled, to address the problems presented by these older, urban neighborhoods and their residents. The dilemna confronting policymakers has been that neglect promises even worse problems, the worst of which have been urban riots triggered by festering social ills. On the other hand, no past active approach has yet solved these problems. After briefly reviewing major federal initiatives, I will focus on the emergence, evolution, and experience of community deveopment coroporations (CDCs) based in these neighborhoods

Report on Three Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm

WOS: 000440491800017PubMed ID: 2966603

Cell proliferation analysis with proliferating cell nuclear antigen (PCNA) and Ki-67 in bone marrow blastic cells of adult acute leukemia

Çalışmada kemik iliğinde blastik hücre infiltrasyonu gösteren 41 erişkin olguda prolifere hücre nükleer antijeni (PCNA) ve Ki-67 antikorları kullanılarak immünohistokimyasal yöntemle proiiferasyon indeksleri belirlenmiş, her iki antikor ile elde edilen proiiferasyon indeksleri kendi aralarında ve lösemi subtipieri arasında kıyasianmıştır. Tüm olguların ortalama PCNA değerleri %60.2+27.4, Ki-67 indeksleri ise %32.1±19.7'dir. Akut lenfoblastik lösemili (ALL) olgularda ortalama PCNA indeksi %46.1+27.7, akut myeloblastik lösemililerde (AML) %64.0±26.6'dır. Ortalama Ki-67 indeksleri ise ALL ve AM-L'lilerde sırasıyla %31.5+19.1 ve %38.0+18.0'dır. Kronik myelositer lösemiden AML'ye blastik dönüşüm gösteren olgularda ise ortalama PCNA indeksi %64.5+27.5, Ki-67 indeksi %11.2+16.0'dir. AML'Iİ olgularda gerek PCNA, gerekse Ki-67 indeksleri ALL'li olgulardan yüksek bulunmuş, ancak fark istatistiksel olarak anlamlı bulunmamıştır.An immunohistochemical study using antibodies against proliferating cell nuclear antigen (PCNA) and Ki-67 was performed on 41 adult patients with bone marrow blastic cell infiltrations. The proliferation indices with both markers were compared between each other and different subtypes of blastic cell infiltrations. The mean PCNA index of all cases was 60.2+27.4% and the corresponding value for Ki-67 was 32.1+19.7%. The mean PCNA and Ki-67 indices of cases with acute lym-phoblastic leukemia (ALL) were 46.1+27.7% and 31.5+19.1%, respectively. The same values for acute myeloblastic leukemia (AML) were 64.0+26.6% and 38.0+18.0%, respectively. The cases with chronic myeloid leukemia (CML) showing blastic transformation to AML had a mean PCNA index of 64.5+27.5% and a mean Ki-67 index of 11.2+16.0%. The difference between the PCNA and Ki-67 indices of ALL and AML was not statistically significant

Unusual case of multicentric mixed-type Castleman's disease presenting with exfoliative dermatitis

Castleman's disease is a rare disorder that results in the underregulated growth of lymphoid tissue. It may present as benign involvement of one lymph node group or as multicentric disease with systemic symptoms. We here present a patient with Castleman's disease of mixed-type and multicentric involvement. © 2004 The International Society of Dermatology