Role of violations prooxidant-antioxidant homeostasis in the pathogenesis of experimental periodontitis in rats = Роль порушень прооксидантно-антиоксидантного гомеостазу в патогенезі експериментального пародонтиту у щурів

Tiupka T. I., Minaeva A. O., Labunec A. O., Zukow W. Role of violations prooxidant-antioxidant homeostasis in the pathogenesis of experimental periodontitis in rats = Роль порушень прооксидантно-антиоксидантного гомеостазу в патогенезі експериментального пародонтиту у щурів. Journal of Education, Health and Sport. 2016;6(1):341-348. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.45491http://ojs.ukw.edu.pl/index.php/johs/article/view/3372https://pbn.nauka.gov.pl/works/711804  The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 01.01.2016. Revised 12.01.2016. Accepted: 31.01.2016.   UDC 616.314.17-008.1-002-008.9-092:612.017.1УДК 616.314.17-008.1-002-008.9-092:612.017.1 ROLE OF VIOLATIONS prooxidant-antioxidant homeostasis in the pathogenesis of experimental periodontitis in rats Роль Порушень прооксидантно-антиоксидантного гомеостазу В патогенезІ експериментального пародонтиту у щурів Т. І. Тюпка, А. О. Мінаєва, А. О. Лабунець, W. ZukowT. I. Tiupka, A. O. Minaeva, A. O. Labunec, W. Zukow Національний фармацевтичний університет, Україна, м. ХарківNational University of Pharmacy, Kharkov Uniwersytet Kazimierza Wielkiego, BydgoszczKazimierz Wielki University, Bydgoszcz AbstractIn the experiment on 30 white non-linear rats found that the pathogenesis of experimental periodontitis significant role played violation prooxidant-antioxidant homeostasis, manifested by activation of lipid peroxidation and decrease activity of antioxidant enzymes, as evidenced by the reduction of antioxidant-prooxidant index as serum, and in periodontal tissue homogenate. The use of exogenous melatonin in experimental periodontitis reduces the generation of free radicals and leads to normalization prooxidant-antioxidant homeostasis confirming the feasibility of its use in pathogenetic therapy of inflammatory diseases periodontal tissues. Keywords: periodontitis, lipid peroxidation, antioxidant protection, melatonin. РезюмеВ експерименті на 30 білих нелінійних щурах встановлено, що у патогенезі експериментального пародонтиту значну роль відіграє порушення прооксидантно-антиоксидантного гомеостазу, що проявляється активацією процесів перекисного окиснення ліпідів і зменшенням активності ферментів антиоксидантного захисту, про що свідчить зниження антиоксидантно-прооксидантного індекса як у сироватці крові, так і в гомогенаті тканин пародонту. Застосування екзогенного мелатоніну при експериментальному пародонтиті зменшує генерацію вільних радикалів та призводить до нормалізації прооксидантно-антиоксидантного гомеостазу, що підтверджує доцільність його застосування в патогенетичній терапії запальних захворювань тканин пародонту. Ключові слова: пародонтит, перекисне окиснення ліпідів, антиоксидантний захист, мелатонін

Overnight affective dynamics and sleep characteristics as predictors of depression and its development

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2030) Dispersion; (120.3180) Interferometry; (270.0270) Quantum Optics

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