FirstLight: Pluggable Optical Interconnect Technologies for Polymeric Electro-Optical Printed Circuit Boards in Data Centers

The protocol data rate governing data storage devices will increase to over 12 Gb/s by 2013 thereby imposing unmanageable cost and performance burdens on future digital data storage systems. The resulting performance bottleneck can be substantially reduced by conveying high-speed data optically instead of electronically. A novel active pluggable 82.5 Gb/s aggregate bit rate optical connector technology, the design and fabrication of a compact electro-optical printed circuit board to meet exacting specifications, and a method for low cost, high precision, passive optical assembly are presented. A demonstration platform was constructed to assess the viability of embedded electro-optical midplane technology in such systems including the first ever demonstration of a pluggable active optical waveguide printed circuit board connector. High-speed optical data transfer at 10.3125 Gb/s was demonstrated through a complex polymer waveguide interconnect layer embedded into a 262 mm × 240 mm × 4.3 mm electro-optical midplane. Bit error rates of less than 10-12 and optical losses as low as 6 dB were demonstrated through nine multimode polymer wave guides with an aggregate data bandwidth of 92.8125 Gb/s

Minimally invasive management of vital teeth requiring root canal therapy

The present study aimed to investigate the possible use of a non-instrumentation technique including blue light irradiation for root canal cleaning. Extracted human single rooted teeth were selected. Nine different groups included distilled water, NaOCl, intra-canal heated NaOCl, and NaOCl + EDTA irrigation after either instrumentation or non-instrumentation, and a laser application group following non-instrumentation technique. The chemical assessment of the root canal dentine was evaluated using EDS and FT-IR. Surface microstructural analyses were performed by using SEM. The antimicrobial efficacy of different preparation techniques was evaluated using microbial tests. Laser application didn’t change the Ca/P, carbonate/phosphate and amide I/phosphate ratios of the root canal dentin the root canal dentin preserved its original form after light application. The instrumentation decreased the carbonate/phosphate and amide I/phosphate ratios of the root canal dentin regardless of the irrigation solution or technique (p < 0.05). According to the microbiological tests, the light application could not provide antibacterial efficacy as much as NaOCl irrigation. The NaOCl irrigation both in the non-instrumentation and instrumentation groups significantly reduced the number of bacteria (p < 0,05). Minimally invasive root canal preparation techniques where the root canal is not instrumented and is disinfected by laser irradiation followed by obturation with a hydraulic cement sealer may be an attractive treatment option for management of vital teeth needing root canal therapy and does not have any detrimental effects on the chemical structure of dentin

Progress in the Development of the 1 m Model of the 70 mm Aperture Quadrupole for the LHC Low-β\beta Insertions

Within the LHC magnet development program Oxford Instruments has built a one metre model of the 70 mm aperture low-beta quadrupole. The magnet features a four layer coil wound from two 8.2 mm wide graded NbTi cables, and is designed for 250 T/m at 1.9 K. The magnet has previously been tested between 4.5 K and 2.3 K. In this paper we review the magnet rebuild and the subsequent tests. Results on magnet training at 4.3 K and 1.9 K are presented along with the results related to quench protection studies.

Implantable and transcutaneous photobiomodulation promote neuroregeneration and recovery of lost function after spinal cord injury

Spinal cord injury (SCI) is a cause of profound and irreversible damage, with no effective therapy to promote functional recovery. Photobiomodulation (PBM) may provide a viable therapeutic approach using red or near-infrared light to promote recovery after SCI by mitigating neuroinflammation and preventing neuronal apoptosis. Our current study aimed to optimize PBM dose regimens and develop and validate the efficacy of an invasive PBM delivery paradigm for SCI. Dose optimization studies were performed using a serum withdrawal model of injury in cultures of primary adult rat dorsal root ganglion neurons (DRGN). Implantable and transcutaneous PBM delivery protocols were developed and validated using cadaveric modeling. The efficacy of PBM in promoting recovery after SCI in vivo was studied in a dorsal column crush injury model of SCI in adult rats. Optimal neuroprotection in vitro was achieved between 4 and 22 mW/cm2. 11 mW/cm2 for 1 min per day (0.66 J/cm2) increased cell viability by 45% over 5 days (p &lt;0.0001), increasing neurite outgrowth by 25% (p &lt; 0.01). A method for invasive application of PBM was developed using a diffusion-tipped optogenetics fiber optic. Delivery methods for PBM were developed and validated for both invasive (iPBM) and noninvasive (transcutaneous) (tcPBM) application. iPBM and tcPBM (24 mW/cm2 at spinal cord, 1 min per day (1.44 J/cm2) up to 7 days) increased activation of regeneration-associated protein at 3 days after SCI, increasing GAP43+ axons in DRGN from 18.0% (control) to 41.4% ± 10.5 (iPBM) and 45.8% ± 3.4 (tcPBM) (p &lt; 0.05). This corresponded to significant improvements at 6 weeks post-injury in functional locomotor and sensory function recovery (p &lt; 0.01), axonal regeneration (p &lt; 0.01), and reduced lesion size (p &lt; 0.01). Our results demonstrated that PBM achieved a significant therapeutic benefit after SCI, either using iPBM or tcPBM application and can potentially be developed for clinical use in SCI patients

Signal value of stress behaviour

Physiological and psychological stress are accompanied by nonverbal behaviour across a wide range of species. The function of this 'stress behaviour' is not well understood but is often assumed to be read by others as a cue to stress. Displaying signs of weakness is, however, difficult to understand from an evolutionary perspective and therefore further investigation into why these behaviours exist is needed. Here, we test whether displacement behaviours (i.e., those known to be associated with stress) are reliable indicators of stress in humans. To do this, we presented raters (N = 133) with videos of individuals (N = 31) undergoing a stress-inducting task. Self-directed displacement behaviours and self-reported stress were both associated with stress ratings given by raters. Therefore, such behaviours can provide reliable information to others and can be considered communicative. Individuals producing more nonverbal stress behaviour were rated as more likeable by raters (perhaps presenting as more honest signallers), indicating a benefit and potential adaptive function of displaying stress. Raters also differed in their accuracy in detecting stress from nonverbal cues. Findings suggest that the accuracy with which individuals were able to detect stress was linked to the number of social connections they reported to have. However, this association was non-linear, with individuals who were most and least accurate reporting the least network connections. This could indicate that the ability to read behaviour is associated with an ability to form and maintain social networks

Quench Performance and Field Quality Measurements of the First LHC low-β\beta Quadrupole Model

As part of the LHC magnet development program, CERN in collaboration with Oxford Instruments has designed, built and tested a one metre model of a 70 mm aperture low-beta quadrupole. The magnet features a four layer coil, and is designed for 250 T/m at 1.9 K. We review the results of the magnet training and quench propagation studies performed at 4.3 K and 1.9 K, and report on the magnetic field measurements

Presupposition projection as proof construction

Even though Van der Sandt's presuppositions as anaphora approach is empirically successful, it fails to give a formal account of the interaction between world-knowledge and presuppositions. In this paper, an algorithm is sketched which is based on the idea of presuppositions as anaphora. It improves on this approach by employing a deductive system, Constructive Type Theory (CTT), to get a formal handle on the way world-knowledge influences presupposition projection. In CTT, proofs for expressions are explicitly represented as objects. These objects can be seen as a generalization of DRT's discourse markers. They are useful in dealing with presuppositional phenomena which require world-knowledge, such as Clark's bridging examples and Beaver's conditional presuppositions