Formation of a culture of interethnic communication among young people with participation in large-scale militarypatriotic events

The article reveals the issues of the formation of the culture of interethnic communication of young people with the use of game forms in the educational program of Patriotic education. The use of an organizational simulation exercise as a form of mental activity, in the Patriotic education of students, contributes to the birth of new experiences, is the mechanism of transformation and development of consciousness of the younger generation, an effective tool in overcoming the different crisis stages in the life of society, as a consequence, the acquisition of updated cultural potential of international communication among youthРаскрываются вопросы формирования культуры межнационального общения молодежи с использованием игровых форм в образовательной программе патриотического воспитания. Применение организационно-деятельностной игры как формы мыследеятельности в патриотическом воспитании студентов способствует рождению нового опыта, является механизмом трансформации и развития сознания представителей молодого поколения, эффективным средством преодоления различных кризисных этапов в жизни общества и, как следствие, способа обретения обновленного культурного потенциала межнационального общения в молодежной сред

Innovation technology forming patriotism among students in the urals region

Представлена инновационная педагогическая технология, применимая при формировании патриотизма у студентов вузовThe article presents an innovative pedagogical technology applicable in the formation of patriotism among student

INNOVATIVE PROJECTS AS A PEDAGOGICAL TECHNOLOGY FOR THE FORMATION OF MORAL AND PATRIOTIC QUALITIES IN PRESCHOOL CHILDREN

The lost process of systematic education of the qualities of patriotism has led to a total problem-spiritual emptiness and a low level of culture of modern society. There is an urgent need to include innovative pedagogical technologies in pre-school education programs that contribute to the formation of Patriotic values and spiritual and moral traits in children from an early age.Утраченный процесс системного воспитания качеств патриотизма привел к тотальной проблеме – духовной опустошённости и низкому уровню культуры современного общества. Возникает острая необходимость включать в программы дошкольного образования инновационные педагогические технологии, способствующие формированию патриотических ценностей и духовно-нравственных черт у детей с раннего возраста.Публикуется при финансовой поддержке гранта РФФИ № 20-413-660013 р_а «Прогнозирование профессионального будущего студенческой молодежи в цифровую эпоху»

Efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment (PIONEER 5): a placebo-controlled, randomised, phase 3a trial

Background: Oral semaglutide is the first oral glucagon-like peptide-1 (GLP-1) receptor agonist for glycaemic control in patients with type 2 diabetes. Type 2 diabetes is commonly associated with renal impairment, restricting treatment options. We aimed to investigate the efficacy and safety of oral semaglutide in patients with type 2 diabetes and moderate renal impairment. Methods: This randomised, double-blind, phase 3a trial was undertaken at 88 sites in eight countries. Patients aged 18 years and older, with type 2 diabetes, an estimated glomerular filtration rate of 30–59 mL/min per 1·73 m2, and who had been receiving a stable dose of metformin or sulfonylurea, or both, or basal insulin with or without metformin for the past 90 days were eligible. Participants were randomly assigned (1:1) by use of an interactive web-response system, with stratification by glucose-lowering medication and renal function, to receive oral semaglutide (dose escalated to 14 mg once daily) or matching placebo for 26 weeks, in addition to background medication. Participants and site staff were masked to assignment. Two efficacy-related estimands were defined: treatment policy (regardless of treatment discontinuation or rescue medication) and trial product (on treatment without rescue medication) in all participants randomly assigned. Endpoints were change from baseline to week 26 in HbA1c (primary endpoint) and bodyweight (confirmatory secondary endpoint), assessed in all participants with sufficient data. Safety was assessed in all participants who received at least one dose of study drug. This trial is registered on ClinicalTrials.gov, number NCT02827708, and the European Clinical Trials Registry, number EudraCT 2015-005326-19, and is now complete. Findings: Between Sept 20, 2016, and Sept 29, 2017, of 721 patients screened, 324 were eligible and randomly assigned to oral semaglutide (n=163) or placebo (n=161). Mean age at baseline was 70 years (SD 8), and 168 (52%) of participants were female. 133 (82%) participants in the oral semaglutide group and 141 (88%) in the placebo group completed 26 weeks on treatment. At 26 weeks, oral semaglutide was superior to placebo in decreasing HbA1c (estimated mean change of −1·0 percentage point (SE 0·1; −11 mmol/mol [SE 0·8]) vs −0·2 percentage points (SE 0·1; −2 mmol/mol [SE 0·8]); estimated treatment difference [ETD]: −0·8 percentage points, 95% CI −1·0 to −0·6;

RELATIONSHIPS OF METEOROLOGICAL FACTORS WITH THE OCCURRENCE OF MYOCARDIAL INFARCTION IN MULTIVESSEL CORONARY ARTERY ATHEROSCLEROSIS IN THE NORTHERN CONDITIONS

The aim of this study was to investigate the association of meteorological factors to the occurrence of myocardial infarction in patients with multivessel coronary atherosclerosis in the North. 337 consecutive patients (278 men and 59 women), mean age 53,7 ± 8,9 years, with acute myocardial infarction (AMI) with ST-segment elevation were examined. In 188 patients (57.0 %) has been revealed multivessel coronary artery disease. It was found that the occurrence of acute myocardial infarction in patients with multivessel coronary atherosclerosis in the North directly associated with indicators of atmospheric pressure on the day of the debut of the disease. Average daily air pressure in the debut day of acute myocardial infarction is one of the factors that directly determine the occurrence of the disease in patients with multivessel coronary atherosclerosis in North (Exp (B) = 1,04, (CI 95 %: 1,01-1, 08), p = 0,012)

Peculiarities of the hospital stage of acute myocardial infarction in patients with varying severity of coronary atherosclerosis on a scale SYNTAX after endovascular treatment

The aim of this study was to investigate characteristics of a hospital phase of acute myocardial infarction in patients with varying degrees of severity of coronary lesions on a scale SYNTAX after endovascular treatment. The severity of coronary lesions on a scale SYNTAX evaluated in 330 consecutive patients (274 men and 56 women), mean age 53.6 ± 8.9 years, with acute myocardial infarction with ST-segment elevation. This patients were divided into three groups: a group with severe coronary disease (SYNTAX ≥ 33), with moderate (SYNTAX from 23 to 32) and low lesion (SYNTAX from 0 to 22). In patients with severe coronary disease had fewer than in patients with low values of the defeat of the Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), and total protein, and high density lipoprotein cholesterol. In groups with SYNTAX from 23 to 32 and with SYNTAX ≥ 33 higher blood glucose levels than in the SYNTAX from 0 to 22, and the rate of urea in patients with severe coronary disease exceed the value of this parameter in patients with low and moderate coronary disease. In patients with severe coronary disease are more likely than those with low lesions observed the phenomenon of non-resumption of blood flow after stenting (no-reflow), stent thrombosis, pulmonary edema, acute aneurysm recurrence of heart attack and bleeding. Using binary logistic regression (χ2 model = 25.4, p < 0.001) we revealed that with heavy coronary lesion (SYNTAX ≥ 33) most significantly associated pleural effusion (p < 0.001), the phenomenon of non-renewal blood flow after stenting (no-reflow) (p = 0.004), and acute aneurysm (p = 0.039)

Gemostaz u detey i vzroslykh s sakharnym diabetom 1 tipa

Цель. Провести сравнительный анализ состояния коагуляционного и тромбоцитарно-сосудистого гемостаза у детей, подростков и взрослых при CД 1. Материалы и методы. Обследовано 335 человек, из них 117 здоровых лиц и 118 детей, подростков и взрослых с СД 1 в возрасте от 11 до 50 лет, которые были разделены на 5 возрастных групп. Дизайн исследования ? простое, сравнительное. Материалом для исследования служила венозная и капиллярная кровь. Оценивали тромбоцитарный гемостаз, коагуляционный гемостаз, антикоагулянтное звено. Результаты. Исследование антикоагулянтных свойств выявило повышение уровня антитромбина III у больных в возрасте от 19 до 25 лет по сравнению со здоровыми людьми соответствующего возраста. Изучение сосудисто-тромбоцитарного гемостаза у данной категории больных выявило снижение содержания тромбоцитов у обследуемых в возрасте от 19 до 25 лет по сравнению с контролем. Хроническая гипергликемия вызывает повышение активности свертывающей системы крови у больных СД 1, что диктует необходимость строгого контроля за показателями гемостаза и коррекции выявленных нарушений. Заключение. Развитие сосудисто-тромбоцитарной дисфункции при сахарном диабете 1 типа не зависит от возраста. Для детей и подростков, больных сахарным диабетом 1 типа, характерно компенсаторное повышение активности антикоагулянтной системы. Активность фибринолитической системы у детей, подростков и взрослых, больных сахарным диабетом, превышает таковую в норме