PYROTECHNICAL SAFETY IN THE PROCESS OF DESTRUCTION OF MINES AND EXPLOSIVE EQUIPMENT (MER) AND UNEXPLODED ORDNANCE (UXO)

This paper deals with the application of pyrotechnic safety in the destruction of MER as one of the riskier processes in working with MER. Knowledge and application of pyrotechnic safety measures, ie the entire pyrotechnic safety system, determination of protected systems, identification of hazards, hazards, risk management and its assessment, are the basic condition for any serious work with MER

Interplane cross-saturation in multiphase machines

The use of electrical machines in electric vehicles and high-power drives frequently requires multiphase machines and multiphase inverters. While appropriate mathematical models under the linear magnetic conditions are readily available for multiphase machines, the same cannot be said for the models of the saturated multiphase machines. This paper examines the saturation in an asymmetrical six-phase induction machine under different supply conditions and addresses the applicability of the existing saturated three-phase machine models for representation of saturated multiphase machines. Specifically, the mutual coupling between different sequence planes in the vector space decomposed model under saturated conditions is analyzed. The paper relies on analytical considerations, finite element analysis and experimental results. It is shown that the saturation of the main flux path is influenced by the current components in the orthogonal (non-fundamental) sequence plane. This implies the need to develop new multiphase machine models which take this effect into account

Simulation of Proton Beam Effects in Thin Insulating Films

Effects of exposing several insulators, commonly used for various purposes in integrated circuits, to beams of protons have been investigated. Materials considered include silicon dioxide, silicon nitride, aluminium nitride, alumina, and polycarbonate (Lexan). The passage of proton beams through ultrathin layers of these materials has been modeled by Monte Carlo simulations of particle transport. Parameters that have been varied in simulations include proton energy and insulating layer thickness. Materials are compared according to both ionizing and nonionizing effects produced by the passage of protons

Modelling and simulation of a novel modular fixture for a flexible manufacturing system

© 2018, Vienna University of Technology. All rights reserved. Wrong or inadequate design and manufacture of modular fixtures can lead to deformations and displacements of workpiece and fixture-workpiece assembly, as well. Deformations and displacements can significantly impact final workpiece accuracy, rendering the fixture less efficient. With that in mind, this paper reviews development of a novel multi-purpose solution for a modular fixture design with higher efficiency, higher accessibility and flexibility. The results of simulations and modelling indicate that the proposed modular fixture design has advantages over the existing, conventional modular fixtures. The proposed framed structure of modular fixtures exhibits versatility in that it allows reliable locating and clamping of workpieces featuring complex geometry and shape. The novel design solution for modular fixtures opens new directions for future investigation, regarding selection and optimization of materials, shape and geometry of fixture elements which can be used to extend and upgrade modular fixtures. All this contributes to higher workpiece quality and accuracy, as well as the higher productivity and lower production costs

Biological and molecular effects of bromodomain and extra-terminal (BET) inhibitors JQ1, IBET-151, and IBET-762 in OSCC cells

Background Despite improvements in oral squamous cell carcinoma (OSCC) management, survival rates remain relatively low and novel anti-neoplastic agents are needed. Bromodomain and extra-terminal (BET) inhibitors proved to be promising agents for cancer treatment. We investigated the effects of three BET inhibitors (JQ1, IBET-151, IBET-762) on SCC-25 cell line and primary oral cancer cell culture. Methods Cell viability was evaluated by MTT. Protein levels of MCM5 and cleaved-PARP were estimated by Western blot. Clonogenic and migratory abilities were determined by colony forming and scratch assays. BET inhibitors effects on mRNA levels of E-Cadherin, Vimentin, SNAI1, SNAI2, CLU, SERPINI1, MCM5, c-Myc, E2F, IL7R, and PPARg were analyzed by qPCR. Results BET inhibitors significantly reduced oral cancer cell viability. JQ1 showed the greatest effect reducing cell viability to 10%, both in SCC-25 and primary OSCC cultures (P lt 0.001), compared to control cells. Cells treated with BET inhibitors displayed a reduction to 50% in colony forming capacity compared to control cells (P lt 0.0001) and the colonies were smaller; they also had a 50%-60% reduction in migratory capacity (P lt 0.05) compared to untreated cells. BET inhibitors had a significant impact on genes related to epithelial to mesenchymal transition and other cancer cell markers, notably on MCM5, a gene related to cell cycle control. Conclusions BET inhibitors induce both OSCC cell death and reduction of tumor aggressiveness. Molecular mechanisms of BET inhibition involve among others, MCM5 downregulation. Importantly, this study demonstrates for the first time the anti-tumoral effect of IBET-151 and IBET-762 in oral cancer