167 research outputs found
Nurses\u27 Alumnae Association Bulletin - Volume 6 Number 10
Financial Report
Calendar of Events
Attention, Class of 1945!
Miss Shafer Retires
Review of the Alumnae Association Meetings
Institutional Staff Nurses\u27 Section
Report of Staff Activites - 1948-1949
The Staff
Stockings! Stockings! Stockings!
Pop-Up Toaster
It\u27s Not Too Soon
Any White Elephants?
Private Duty Section
The Jefferson Hospital Private Duty Nurses\u27 Register
Report for Barton Memorial Hospital
Progress of the Orthopedic Department
Just Under the Date Line
Pediatrics at Jefferson
Controlled Respiration in Anesthesia
Anesthesia Progress
Physical Advances at Jefferson During the Past Year
The White Haven Division
The Clara Melville Scholarship Fund
The Relief Fund
The Busy Year for the Nurses\u27 Home Committee of the Women\u27s Board
The Gray Ladies
Memories
Lost
Miscellaneous Items
Medical College News
Marriages
Births
Deaths
Condolences
Prizes
District No. 1 Dues
Help! Help! Help!
Jap Prison School Spurs Nurse to Win University Degree
Twenty Ways to Kill an Organization
The Bulletin Committee
Attention, Alumnae
New Addresse
Effects of gamma irradiation on the biomechanical properties of peroneus tendons
PURPOSE: This study was designed to investigate the biomechanical properties of nonirradiated (NI) and irradiated (IR) peroneus tendons to determine if they would be suitable allografts, in regards to biomechanical properties, for anterior cruciate ligament reconstruction after a dose of 1.5â2.5 Mrad. METHODS: Seven pairs of peroneus longus (PL) and ten pairs of peroneus brevis (PB) tendons were procured from human cadavers. The diameter of each allograft was measured. The left side of each allograft was IR at 1.5â2.5 Mrad, whereas the right side was kept aseptic and NI. The allografts were thawed, kept wet with saline, and attached in a single-strand fashion to custom freeze grips using liquid nitrogen. A preload of 10 N was then applied and, after it had reached steady state, the allografts were pulled at 4 cm/sec. The parameters recorded were the displacement and force. RESULTS: The elongation at the peak load was 10.3±2.3 mm for the PB NI side and 13.5±3.3 mm for the PB IR side. The elongation at the peak load was 17.4±5.3 mm for the PL NI side and 16.3±2.0 mm for the PL IR side. For PL, the ultimate load was 2,091.6±148.7 N for NI and 2,122.8±380.0 N for IR. The ultimate load for the PB tendons was 1,485.7±209.3 N for NI and 1,318.4±296.9 N for the IR group. The ultimate stress calculations for PL were 90.3±11.3 MPa for NI and 94.8±21.0 MPa for IR. For the PB, the ultimate stress was 82.4±19.0 MPa for NI and 72.5±16.6 MPa for the IR group. The structural stiffness was 216.1±59.0 N/mm for the NI PL and 195.7±51.4 N/mm for the IR side. None of these measures were significantly different between the NI and IR groups. The structural stiffness was 232.1±45.7 N/mm for the NI PB and 161.9±74.0 N/mm for the IR side, and this was the only statistically significant difference found in this study (P=0.034). CONCLUSION: Our statistical comparisons found no significant differences in terms of elongation, ultimate load, or ultimate stress between IR and NI PB and PL tendons. Only the PB structural stiffness was affected by irradiation. Thus, sterilizing allografts at 1.5â2.5 Mrad of gamma irradiation does not cause major alterations in the tendonsâ biomechanical properties while still providing a suitable amount of sterilization for anterior cruciate ligament reconstruction
Caledonian hot zone magmatism in the âNewer Granitesâ: insight from the Cluanie and Clunes plutons, Northern Scottish Highlands
Scottish âNewerâ Granites record the evolution of the Caledonides resulting from Iapetus subduction and slab breakoff during the Silurian-Devonian Scandian Orogeny, but relationships between geodynamics, petrogenesis and emplacement are incomplete. Laser ablation U-Pb results from magmatic zircons at the Cluanie Pluton (Northern Highlands) identify clusters of concordant Silurian data points. A cluster with a weighted mean 206Pb/238U age of 431.6 ± 1.3 Ma (2 confidence interval, n = 6) records emplacement whilst older points (clustered at 441.8 ± 2.3 Ma, n = 9) record deep crustal hot zone magmatism prior to ascent. The Cluanie Pluton, and its neighbour the âŒ428 Ma Clunes tonalite, have adakite-like high Na, Sr/Y, La/Yb and low Mg, Ni and Cr characteristics, and lack mafic facies common in other âNewer Granitesâ. These geochemical signatures indicate the tapping of batches of homogenised, evolved magma from the deeper crust. The emplacement age of the Cluanie Pluton confirms volumetrically modest subduction-related magmatism occurred beneath the Northern Highlands before slab breakoff, probably as a result of crustal thickening during the âŒ450 Ma Grampian 2 event. Extensive new in-situ geochemical-geochronological studies for this terrane may further substantiate the deep crustal hot zone model and the association between Caledonian magmatism and potentially metallogenesis. The term âNewer Granitesâ is outdated as it ignores the demonstrated relationships between magmatism, Scandian orogenesis and slab breakoff. Hence, âCaledonian intrusionsâ would be a more appropriate generic term to cover those bodies related to either Iapetus subduction or to slab breakoff
Quantum Cosmological Relational Model of Shape and Scale in 1-d
Relational particle models are useful toy models for quantum cosmology and
the problem of time in quantum general relativity. This paper shows how to
extend existing work on concrete examples of relational particle models in 1-d
to include a notion of scale. This is useful as regards forming a tight analogy
with quantum cosmology and the emergent semiclassical time and hidden time
approaches to the problem of time. This paper shows furthermore that the
correspondence between relational particle models and classical and quantum
cosmology can be strengthened using judicious choices of the mechanical
potential. This gives relational particle mechanics models with analogues of
spatial curvature, cosmological constant, dust and radiation terms. A number of
these models are then tractable at the quantum level. These models can be used
to study important issues 1) in canonical quantum gravity: the problem of time,
the semiclassical approach to it and timeless approaches to it (such as the
naive Schrodinger interpretation and records theory). 2) In quantum cosmology,
such as in the investigation of uniform states, robustness, and the qualitative
understanding of the origin of structure formation.Comment: References and some more motivation adde
International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol
Epilepsy is one of the most common chronic neurological diseases in veterinary practice. Magnetic resonance imaging (MRI) is regarded as an important diagnostic test to reach the diagnosis of idiopathic epilepsy. However, given that the diagnosis requires the exclusion of other differentials for seizures, the parameters for MRI examination should allow the detection of subtle lesions which may not be obvious with existing techniques. In addition, there are several differentials for idiopathic epilepsy in humans, for example some focal cortical dysplasias, which may only apparent with special sequences, imaging planes and/or particular techniques used in performing the MRI scan. As a result, there is a need to standardize MRI examination in veterinary patients with techniques that reliably diagnose subtle lesions, identify post-seizure changes, and which will allow for future identification of underlying causes of seizures not yet apparent in the veterinary literature.
There is a need for a standardized veterinary epilepsy-specific MRI protocol which will facilitate more detailed examination of areas susceptible to generating and perpetuating seizures, is cost efficient, simple to perform and can be adapted for both low and high field scanners. Standardisation of imaging will improve clinical communication and uniformity of case definition between research studies. A 6â7 sequence epilepsy-specific MRI protocol for veterinary patients is proposed and further advanced MR and functional imaging is reviewed
A Spitzer Space Telescope Infrared Survey of Supernova Remnants in the Inner Galaxy
Using Infrared Array Camera (IRAC) images at 3.6, 4.5, 5.8, and 8 microns
from the GLIMPSE Legacy science program on the Spitzer Space Telescope, we
searched for infrared counterparts to the 95 known supernova remnants that are
located within galactic longitudes 65>|l|>10 degrees and latitudes |b|<1
degree. Eighteen infrared counterparts were detected. Many other supernova
remnants could have significant infrared emission but are in portions of the
Milky Way too confused to allow separation from bright HII regions and
pervasive mid-infrared emission from atomic and molecular clouds along the line
of sight. Infrared emission from supernova remnants originates from synchrotron
emission, shock-heated dust, atomic fine-structure lines, and molecular lines.
The detected remnants are G11.2-0.3, Kes 69, G22.7-0.2, 3C 391, W 44, 3C 396,
3C 397, W 49B, G54.4-0.3, Kes 17, Kes 20A, RCW 103, G344.7-0.1, G346.6-0.2, CTB
37A, G348.5-0.0, and G349.7+0.2. The infrared colors suggest emission from
molecular lines (9 remnants), fine-structure lines (3), and PAH (4), or a
combination; some remnants feature multiple colors in different regions. None
of the remnants are dominated by synchrotron radiation at mid-infrared
wavelengths. The IRAC-detected sample emphasizes remnants interacting with
relatively dense gas, for which most of the shock cooling occurs through
molecular or ionic lines in the mid-infrared.Comment: Accepted 10/18/2005 for publication in "The Astronomical Journal".
The figures in this astro-ph submission are drastically reduced in quality in
order to fit within its limit
Recommended from our members
Differential Stem and Progenitor Cell Trafficking by Prostaglandin E2
SUMMARY To maintain lifelong production of blood cells, hematopoietic stem cells (HSC) are tightly regulated by inherent programs and extrinsic regulatory signals received from their microenvironmental niche. Long-term repopulating HSC (LT-HSC) reside in several, perhaps overlapping, niches that produce regulatory molecules/signals necessary for homeostasis and increased output following stress/injury 1â5. Despite significant advances in specific cellular or molecular mechanisms governing HSC/niche interactions, little is understood about regulatory function within the intact mammalian hematopoietic niche. Recently, we and others described a positive regulatory role for Prostaglandin E2 (PGE2) on HSC function ex vivo 6,7. While exploring the role of endogenous PGE2 we unexpectedly observed hematopoietic egress after nonsteroidal anti-inflammatory drug (NSAID) treatment. Surprisingly, this was independent of the SDF-1/CXCR4 axis. Stem and progenitor cells were found to have differing mechanisms of egress, with HSC transit to the periphery dependent on niche attenuation and reduction in the retentive molecule osteopontin (OPN). Hematopoietic grafts mobilized with NSAIDs had superior repopulating ability and long-term engraftment. Treatment of non-human primates and healthy human volunteers confirmed NSAID-mediated egress in higher species. PGE2 receptor knockout mice demonstrated that progenitor expansion and stem/progenitor egress resulted from reduced EP4 receptor signaling. These results not only uncover unique regulatory roles for EP4 signaling in HSC retention in the niche but also define a rapidly translatable strategy to therapeutically enhance transplantation
International Veterinary Epilepsy Task Force recommendations for systematic sampling and processing of brains from epileptic dogs and cats
Traditionally, histological investigations of the epileptic brain are required to identify epileptogenic brain lesions, to evaluate the impact of seizure activity, to search for mechanisms of drug-resistance and to look for comorbidities. For many instances, however, neuropathological studies fail to add substantial data on patients with complete clinical work-up. This may be due to sparse training in epilepsy pathology and or due to lack of neuropathological guidelines for companion animals.
The protocols introduced herein shall facilitate systematic sampling and processing of epileptic brains and therefore increase the efficacy, reliability and reproducibility of morphological studies in animals suffering from seizures.
Brain dissection protocols of two neuropathological centres with research focus in epilepsy have been optimised with regards to their diagnostic yield and accuracy, their practicability and their feasibility concerning clinical research requirements.
The recommended guidelines allow for easy, standardised and ubiquitous collection of brain regions, relevant for seizure generation. Tissues harvested the prescribed way will increase the diagnostic efficacy and provide reliable material for scientific investigations
The Far Ultraviolet Spectroscopic Explorer Survey of OVI Absorption in the Disk of the Milky Way
To probe the distribution and physical characteristics of interstellar gas at
temperatures T ~ 3e5 K in the disk of the Milky Way, we have used the Far
Ultraviolet Spectroscopic Explorer (FUSE) to observe absorption lines of OVI
toward 148 early-type stars situated at distances 1 kpc. After subtracting off
a mild excess of OVI arising from the Local Bubble, combining our new results
with earlier surveys of OVI, and eliminating stars that show conspicuous
localized X-ray emission, we find an average OVI mid-plane density n_0 = 1.3e-8
cm^-3. The density decreases away from the plane of the Galaxy in a way that is
consistent with an exponential scale height of 3.2 kpc at negative latitudes or
4.6 kpc at positive latitudes. Average volume densities of OVI along different
sight lines exhibit a dispersion of about 0.26 dex, irrespective of the
distances to the target stars. This indicates that OVI does not arise in
randomly situated clouds of a fixed size and density, but instead is
distributed in regions that have a very broad range of column densities, with
the more strongly absorbing clouds having a lower space density. Line widths
and centroid velocities are much larger than those expected from differential
Galactic rotation, but they are nevertheless correlated with distance and
N(OVI), which reinforces our picture of a diverse population of hot plasma
regions that are ubiquitous over the entire Galactic disk. The velocity
extremes of the OVI profiles show a loose correlation with those of very strong
lines of less ionized species, supporting a picture of a turbulent, multiphase
medium churned by shock-heated gas from multiple supernova explosions.Comment: Accepted for publication in ApJS. Preprint with full resolution
images and all 148 spectra available at
http://www.astro.princeton.edu/~dvb/o
Mendelian randomization analysis of C-reactive protein on colorectal cancer risk
Background: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also moderately associated with CRC risk. However, observational studies are susceptible to unmeasured confounding or reverse causality. Using genetic risk variants as instrumental variables, we investigated the causal relationship between genetically elevated CRP concentration and CRC risk, using a Mendelian randomization approach. Methods: Individual-level data from 30 480 CRC cases and 22 844 controls from 33 participating studies in three international consortia were used: the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT) and the Colon Cancer Family Registry (CCFR). As instrumental variables, we included 19 single nucleotide polymorphisms (SNPs) previously associated with CRP concentration. The SNP-CRC associations were estimated using a logistic regression model adjusted for age, sex, principal components and genotyping phases. An inverse-variance weighted method was applied to estimate the causal effect of CRP on CRC risk. Results: Among the 19 CRP-associated SNPs, rs1260326 and rs6734238 were significantly associated with CRC risk (P = 7.5 Ă 10-4, and P = 0.003, respectively). A genetically predicted one-unit increase in the log-transformed CRP concentrations (mg/l) was not associated with increased risk of CRC [odds ratio (OR) = 1.04; 95% confidence interval (CI): 0.97, 1.12; P = 0.256). No evidence of association was observed in subgroup analyses stratified by other risk factors. Conclusions: In spite of adequate statistical power to detect moderate association, we found genetically elevated CRP concentration was not associated with increased risk of CRC among individuals of European ancestry. Our findings suggested that circulating CRP is unlikely to be a causal factor in CRC development
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