Using a knowledge management evaluation framework for improving an ERP system - a Hong Kong construction industry case study

Organisations need to rely on leadership, information support and human capital in order to ensure a knowledge advantage over their competitors. Knowledge management (KM) provides organisations with sustainable competitive advantage, because it becomes extremely difficult for an organisation to cut expenditure and increase revenue by simply reengineering its business model. Project delivery and success has been traditionally viewed and measured as management of a three-legged stool, with the legs defined as cost, schedule and quality. However, KM can be linked to success by organisations becoming more effective as well as being more efficient.This paper uses a KM framework, the Knowledge Advantage (K-Adv), developed initially for use by construction organisations. It assesses the impact of leadership and its supporting information communication technology infrastructure on the ability of people (by effectively creating, sharing, disseminating and using knowledge) to facilitate sustainable competitive advantage.A case study that is presented is based upon the experience of a leading construction company using an Enterprise Resources Planning (ERP) system to demonstrate the effectiveness of KM from a cost management business unit perspective. Results are evaluated using a capability maturity model (CMM) - that forms the core of the K-Adv tool - to help improve processes that meet the needs of the organisation operating in a highly dynamic business environment. The case study is part of a broader doctoral research project that uses action learning to facilitate and measure ERP improvement.<br /

Improve construction knowledge management system by using the soft system methodology

The construction industry has a poor record in the management of its knowledge and results into huge wastage of resources and detrimental effect to quality. Research has shown that data and information management system plus knowledge management are a critical part of today\u27s project management practice for construction projects. Few people will deny that \u27quality information\u27 and \u27useful knowledge\u27 are extremely important to any decision-making. However, the current processes of handling information and knowledge in the construction industry and increasingly costly. One of the major reasons is the nature of this industry is not conducive to good knowledge management and the traditional data/information systems used in the industry has long been critisized. It is very common that information is often duplicated, inconsistent and not current. In turn, making knowledge becomes difficult to manage properly. Project managers have in the past found it very difficult to source and analyse data in order to make sound decisions. This paper is part of a doctoral research project which summarizes three exploratory surveys; namely ERP system, Partnering strategy and Leadership impact of a knowledge management system in a construction company. Those findings are described by using the Soft Systems Methodology (SSM) which later becomes the basis for actions research. SSM is useful to reveal complexities of the knowledge management situations that occur in construction industry. The first stage was to conduct interviews of the different practices in knowledge and reporting process. Then, the SSM rich picture was developed to present the problematic areas including difficulties in inputting data to enable the knowledge platform in place. The research then develops root definition and CATWOE, and a conceptual model was formed. Interviewees were conducted with structured questions to identify prioritized actions and activities that can be undertaken to improve and manage the knowledge platform

Imatinib Mesylate Inhibits Platelet-Derived Growth Factor Receptor Phosphorylation of Melanoma Cells But Does Not Affect Tumorigenicity In Vivo

Platelet-derived growth factor (PDGF) and its cognate receptor are widely expressed on melanomas. Coexpression of the growth factor and receptor suggests their role in autocrine or paracrine growth mechanisms. Imatinib mesylate was previously reported to have specific activity in inhibiting select tyrosine kinase receptors, including PDGF and c-Kit. Melanoma cells express abundant levels of the PDGF receptor (PDGFR). Nevertheless, c-Kit expression is progressively lost as the cells take on a more highly metastatic phenotype. To investigate the potential of imatinib mesylate as a therapy for melanoma, we studied its effect on the growth of melanoma cells using an in vivo mouse model. Melanoma cells with high malignant potential (PDGFR-positive, c-Kit-negative) or low malignant potential (PDGFR-positive, c-Kit-positive) were injected subcutaneously into athymic nude mice. Mice were treated with imatinib mesylate (100 mg/kg three times weekly) or with phosphate-buffered saline for 4 to 6 wk. PDGFR-α and -β were expressed on all melanoma cell lines tested. The level of PDGFR expression correlated with the metastatic potential of the melanoma cells: higher levels of PDGFR-α were expressed on cells with higher metastatic potential, and higher levels of PDGFR-β were expressed on cells with lower metastatic potential. There was no significant difference in tumor size between treated and control mice. Immunohistochemical studies demonstrated inhibition of PDGFR phosphorylation on the tumors from mice treated with imatinib mesylate but not from control mice, suggesting that the receptors were functional and that the concentration of drug used was appropriate. Our data demonstrated that imatinib mesylate blocked both PDGFR-α and PDGFR-βin vivo. It did not, however, affect the growth of melanoma cells expressing PDGFR, regardless of whether the cells expressed c-Kit

The Discovery of the Long-Period, Eccentric Planet Kepler-88 d and System Characterization with Radial Velocities and Photodynamical Analysis

We present the discovery of Kepler-88 d (P_d = 1403±14 , M sin i_d = 970±50M⊕ = 3.05±0.16M_J, e_d = 0.42±0.04) based on six years of radial velocity (RV) follow-up from the W. M. Keck Observatory High Resolution Echelle Spectrometer spectrograph. Kepler-88 has two previously identified planets. Kepler-88 b (KOI-142.01) transits in the NASA Kepler photometry and has very large transit timing variations (TTVs). Nesvorný et al. performed a dynamical analysis of the TTVs to uniquely identify the orbital period and mass of the perturbing planet (Kepler-88 c), which was later was confirmed with RVs from the Observatoire de Haute-Provence (OHP). To fully explore the architecture of this system, we performed photodynamical modeling on the Kepler photometry combined with the RVs from Keck and OHP and stellar parameters from spectroscopy and Gaia. Planet d is not detectable in the photometry, and long-baseline RVs are needed to ascertain its presence. A photodynamical model simultaneously optimized to fit the RVs and Kepler photometry yields the most precise planet masses and orbital properties yet for b and c: P_b = 10.91647±0.00014days, M_b = 9.5±1.2M⊕, P_c = 22.2649±0.0007 days, and M_c = 214.1±5.3M⊕. The photodynamical solution also finds that planets b and c have low eccentricites and low mutual inclination, are apsidally anti-aligned, and have conjunctions on the same hemisphere of the star. Continued RV follow-up of systems with small planets will improve our understanding of the link between inner planetary system architectures and giant planets

An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration

SummaryDownregulation of the miR-143/145 microRNA (miRNA) cluster has been repeatedly reported in colon cancer and other epithelial tumors. In addition, overexpression of these miRNAs inhibits tumorigenesis, leading to broad consensus that they function as cell-autonomous epithelial tumor suppressors. We generated mice with deletion of miR-143/145 to investigate the functions of these miRNAs in intestinal physiology and disease in vivo. Although intestinal development proceeded normally in the absence of these miRNAs, epithelial regeneration after injury was dramatically impaired. Surprisingly, we found that miR-143/145 are expressed and function exclusively within the mesenchymal compartment of intestine. Defective epithelial regeneration in miR-143/145-deficient mice resulted from the dysfunction of smooth muscle and myofibroblasts and was associated with derepression of the miR-143 target Igfbp5, which impaired IGF signaling after epithelial injury. These results provide important insights into the regulation of epithelial wound healing and argue against a cell-autonomous tumor suppressor role for miR-143/145 in colon cancer

Effectiveness of Interventions to Reduce Contact Rates during a Simulated Influenza Pandemic

Measures to decrease contact between persons during an influenza pandemic have been included in pandemic response plans. We used stochastic simulation models to explore the effects of school closings, voluntary confinements of ill persons and their household contacts, and reductions in contacts among long-term care facility (LTCF) residents on pandemic-related illness and deaths. Our findings suggest that school closings would not have a substantial effect on pandemic-related outcomes in the absence of measures to reduce out-of-school contacts. However, if persons with influenzalike symptoms and their household contacts were encouraged to stay home, then rates of illness and death might be reduced by ≈50%. By preventing ill LTCF residents from making contact with other residents, illness and deaths in this vulnerable population might be reduced by ≈60%. Restricting the activities of infected persons early in a pandemic could decrease negative health impact

Discovery of a Third Transiting Planet in the Kepler-47 Circumbinary System

Of the nine confirmed transiting circumbinary planet systems, only Kepler-47 is known to contain more than one planet. Kepler-47 b (the "inner planet") has an orbital period of 49.5 days and a radius of about 3 R⊕. Kepler-47 c (the "outer planet") has an orbital period of 303.2 days and a radius of about 4.7 R⊕. Here we report the discovery of a third planet, Kepler-47 d (the "middle planet"), which has an orbital period of 187.4 days and a radius of about 7 R⊕. The presence of the middle planet allows us to place much better constraints on the masses of all three planets, where the 1σranges are less than 26 M⊕, between 7–43 M⊕, and between 2–5 M⊕ for the inner, middle, and outer planets, respectively. The middle and outer planets have low bulk densities, with ρ_(middle) < 0.68 g cm^(−3) and ρ_(outer) < 0.26 g cm^(−3) at the 1σ level. The two outer planets are "tightly packed," assuming the nominal masses, meaning no other planet could stably orbit between them. All of the orbits have low eccentricities and are nearly coplanar, disfavoring violent scattering scenarios and suggesting gentle migration in the protoplanetary disk

The turbulent gas structure in the centers of NGC253 and the Milky Way

We compare molecular gas properties in the starbursting center of NGC253 and the Milky Way Galactic Center (GC) on scales of ~1-100 pc using dendograms and resolution-, area- and noise-matched datasets in CO (1-0) and CO (3-2). We find that the size-line width relations in NGC253 and the GC have similar slope, but NGC253 has larger line widths by factors of ~2-3. The $\sigma^2/R$ dependency on column density shows that, in the GC, on scales of 10-100 pc the kinematics of gas over $N>3\times10^{21}$ cm$^{-2}$ are compatible with gravitationally bound structures. In NGC253 this is only the case for column densities $N>3\times10^{22}$ cm$^{-2}$. The increased line widths in NGC253 originate in the lower column density gas. This high-velocity dispersion, not gravitationally self-bound gas is likely in transient structures created by the combination of high average densities and feedback in the starburst. The high densities turns the gas molecular throughout the volume of the starburst, and the injection of energy and momentum by feedback significantly increases the velocity dispersion at a given spatial scale over what is observed in the GC.Comment: 13 pages, 3 figures, 4 tables; accepted for publication in the Astrophysical Journa