The modeling and control of freeze dryers

Two models of the freeze drying process were constructed and used to study various operational policies in order to determine the policy that would provide the shortest drying times. The sublimation model which accounts only for the removal of frozen water, is found to predict shorter times for the free water removal phase than the sorption-sublimation model which properly accounts for the removal of frozen and bound water. This study shows that the policy which produces the shortest free water removal phase, also produces the shortest overall drying time. This policy, predicted by both models, holds the chamber pressure at its lowest value, heats the upper surface by radiation and the lower surface by conduction, the heating plates operate at different temperatures such that the melting and scorch constraints are both encountered and held during free water removal phase, and uses a low condenser temperature. During the free water removal phase, at least 80% of the total amount of heat supplied to the sample, is transferred through the frozen layer. The sorption-sublimation model provides sorbed water as well as temperature profiles in the dried layer during the free water removal phase and during the terminal drying phase. This study, by developing bound water profiles, incorporates an important factor for operational policies for quality retention in freeze drying. The temperature and sorbed water data predicted by the sorption-sublimation model during drying, can be combined with kinetic data on product deterioration to determine operational policies which may minimize not only the drying time but also the deteriorative changes. The economics of the freeze drying process were also studied, and it is shown that the policy that produces the shortest drying time, will operate the dryer most economically for a given sample thickness. The economic analysis suggests that large sample sizes would increase dryer capacity, and models which account for the removal of frozen water only, predict erroneous economic results --Abstract, pages iii-iv

DPLA Exchange and SimplyE, an open platform for e-content services

This presentation describes a pilot program spearheaded by the Digital Public Library of America (DPLA) to test a new model for a library-owned and library-centered ebook marketplace for popular ebooks, together with free public domain and openly-licensed ebooks. The goal of the program is to demonstrate how DPLA can help libraries maximize access to ebooks for their patrons. For the pilot, DPLA sought out a mix of library types including a state library, a consortium, and both a large public library and one serving smaller and rural populations. The diverse group of pilot libraries are: Alameda County Library (CA); Carnegie Library of Pittsburgh (PA); Connecticut State Library (CT); Califa Library Group (CA, KS); St. Mary’s County Library (MD) and Yavapai Library Network (AZ)

Core Services in the Architecture of the National Digital Library for Science Education (NSDL)

We describe the core components of the architecture for the (NSDL) National Science, Mathematics, Engineering, and Technology Education Digital Library. Over time the NSDL will include heterogeneous users, content, and services. To accommodate this, a design for a technical and organization infrastructure has been formulated based on the notion of a spectrum of interoperability. This paper describes the first phase of the interoperability infrastructure including the metadata repository, search and discovery services, rights management services, and user interface portal facilities

Pain Management in the Neonatal Piglet During Routine Management Procedures. Part 1: A Systematic Review of Randomized and Non-Randomized Intervention Studies

Routine procedures carried out on piglets (i.e. castration, tail docking, teeth clipping, and ear notching) are considered painful. Unfortunately the efficacy of current pain mitigation modalities is poorly understood. The aim of this systematic review was to synthesize the existing primary scientific literature regarding the effectiveness of pain management interventions used for routine procedures on piglets. The review question was, \u27In piglets under twenty-eight days old, undergoing castration, tail docking, teeth clipping, and/or methods of identification that involve cutting of the ear tissue, what is the effect of pain mitigation compared with no pain mitigation on behavioral and non-behavioral outcomes that indicate procedural pain and post-procedural pain?\u27 A review protocol was designed a priori. Data sources used were Agricola (EBSCO), CAB Abstracts (Thomson Reuters), PubMed, Web of Science (Thomson Reuters), BIOSIS Previews (Thomson Reuters), and ProQuest Dissertations & Theses Full Text. No restrictions on year of publication or language were placed on the search. Eligible studies assessed an intervention designed to mitigate the pain of the procedures of interest and included a comparison group that did not receive an intervention. Eligible non-English studies were translated using a translation service. Two reviewers independently screened titles and abstracts for relevance using pre-defined questions. Data were extracted from relevant articles onto pre-defined forms. From the 2203 retrieved citations forty publications, containing 52 studies met the eligibility criteria. In 40 studies, piglets underwent castration only. In seven studies, piglets underwent tail docking only. In one study, piglets underwent teeth clipping only, and in one study piglets underwent ear notching only. Three studies used multiple procedures. Thirty-two trial arms assessed general anesthesia protocols, 30 trial arms assessed local anesthetic protocols, and 28 trial arms assessed non-steroidal anti-inflammatory drugs (NSAIDs) protocols. Forty-one trial arms were controls where piglets received either placebo or no treatment. Forty-five outcomes were extracted from the studies, however only the results from studies that assessed cortisol (six studies), β-endorphins (one study), vocalisations (nine studies), and pain-related behaviors (nine studies) are reported. Other outcomes were reported in only one or two studies. Confident decision making will likely be difficult based on this body of work because lack of comprehensive reporting precludes calculation of the magnitude of pain mitigation for most outcomes

A Programme for Women achieving Excellence in Research (PoWER): theoretically informed intervention design and evaluation

Academics in Higher Education are often expected both to teach and to research; this is a particular challenge for women both structurally and individually. Initiatives to address structural issues include AdvanceHE. Here, we focus on individual issues and report on the Programme for Women Achieving Excellence in Research, a theory-based intervention. Barriers to success were assessed and course content tailored accordingly. Evaluation demonstrated that barriers were reduced and that confidence increased. Although the barriers are both individual and contextual, our rigorous approach allows international application through intervention modification without loss of fidelity. This offers a new approach for academic developers to enable female researchers

Combining Enzalutamide with Abiraterone, Prednisone, and Androgen Deprivation Therapy in the STAMPEDE Trial

There are compelling reasons to study the addition of both enzalutamide and abiraterone, in combination, to standard-of-care for hormone-naïve prostate cancer. Through a protocol amendment, this will be assessed in the STAMPEDE trial, with overall survival as primary outcome measure. © 2014 European Association of Urology

Cost-utility analysis of adding abiraterone acetate plus prednisone/prednisolone to long-term hormone therapy in newly diagnosed advanced prostate cancer in England: Lifetime decision model based on STAMPEDE trial data

Adding abiraterone acetate (AA) plus prednisolone (P) to standard of care (SOC) improves survival in newly diagnosed advanced prostate cancer (PC) patients starting hormone therapy. Our objective was to determine the value for money to the English National Health Service (NHS) of adding AAP to SOC. We used a decision analytic model to evaluate cost-effectiveness of providing AAP in the English NHS. Between 2011-2014, the STAMPEDE trial recruited 1917 men with high-risk localised, locally advanced, recurrent or metastatic PC starting first-line androgen-deprivation therapy (ADT), and they were randomised to receive SOC plus AAP, or SOC alone. Lifetime costs and quality-adjusted life-years (QALYs) were estimated using STAMPEDE trial data supplemented with literature data where necessary, adjusting for baseline patient and disease characteristics. British National Formulary (BNF) prices (£98/day) were applied for AAP. Costs and outcomes were discounted at 3.5%/year. AAP was not cost-effective. The incremental cost-effectiveness ratio (ICER) was £149,748/QALY gained in the non-metastatic (M0) subgroup, with 2.4% probability of being cost-effective at NICE's £30,000/QALY threshold; and the metastatic (M1) subgroup had an ICER of £47,503/QALY gained, with 12.0% probability of being cost-effective. Scenario analysis suggested AAP could be cost-effective in M1 patients if priced below £62/day, or below £28/day in the M0 subgroup. AAP could dominate SOC in the M0 subgroup with price below £11/day. AAP is effective for non-metastatic and metastatic disease but is not cost-effective when using the BNF price. AAP currently only has UK approval for use in a subset of M1 patients. The actual price currently paid by the English NHS for abiraterone acetate is unknown. Broadening AAP's indication and having a daily cost below the thresholds described above is recommended, given AAP improves survival in both subgroups and its cost-saving potential in M0 subgroup