Paper Session III-A - Design of a Portable Data Collection Procedure System for Processing Space Shuttle Payloads and Main Engines at the Kennedy Space Center

The Portable Data Collection (PDC) Procedure System is currently being developed to allow Work Authorization Documents (WADs) to be run electronically at the Kennedy Space Center (KSC). WADs are used throughout KSC to perform various tests, maintenance, and integration tasks, including processing of Space Shuttle Main Engine hardware and Space Shuttle Payloads. The PDC system is targeted for use in the Space Shuttle Main Engine Shop, and for Space Station Resupply and Return ground processing, in 1998. With the PDC system, the work procedure is converted from a word processor document to a database. It is then executed using standard work stations and portable computers. All data is entered electronically and stored in the database. This includes quality stamps, signatures, notes, and task data. The system immediately distributes entered data to all other terminals viewing the same document. The current ink stamp is replaced with an electronic stamp

Quantum Opacity, the RHIC HBT Puzzle, and the Chiral Phase Transition

We present a relativistic quantum mechanical treatment of opacity and refractive effects that allows reproduction of observables measured in two-pion (HBT) interferometry and pion spectra at RHIC. The inferred emission duration is substantial. The results are consistent with the emission of pions from a system that has a restored chiral symmetry.Comment: 4 pages, 2 figures. This version mentions shows the STAR 200 GeV data, and includes some technical improvements. The agreement with experiment is improved slightly, and the parameters of the model are changed slightl

The feasibility and acceptability of using a novel wrist worn cueing device to self-manage drooling problems in people with Parkinson’s disease: A pilot study

Introduction: Daytime drooling is experienced by around 50% of Parkinson’s patients, who fail to swallow saliva in sufficient volume or regularity, despite normal production. This research explored the feasibility and acceptability of using a cueing device, to improve drooling. Methods: During a 4-week intervention, 28 participants were asked to use a cueing device for one hour per day. During this time, the device vibrated once-per-minute, reminding the participant to swallow their saliva. A daily diary was used to collect self-report around swallowing severity, frequency and duration. This was filled out by participants for 1 week before, 4 weeks during, and for 1 week immediately after intervention. Diaries were also collected for 1 week during a follow up, carried out 4 weeks after intervention finished. Results: Participants self-reported benefits in drooling severity (p=0.031), frequency (p=<0.001), and duration (p=0.001) after using the device. Improvements were maintained at follow up. Twenty-two participants explicitly reported a positive benefit to their drooling during exit interview. All felt the intervention and device were acceptable and usable. Conclusions: Using a cueing device for 1 month had perceived benefit to drooling severity, frequency and duration in patients with Parkinson’s. Participants accepted the device and treatment protocol

Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the β-globin locus control region. Domain opening and synergism between HS2 and HS3

The roles of each DNase hypersensitive site (HS), and the DNA sequences between them, in the activity of the locus control region of the mammalian β-globin gene domain were examined by placing human and rabbit restriction fragments containing the cores of HS2, HS3, HS4, and HS5, along with varying amounts of flanking DNA, upstream of a hybrid ε-globin-luciferase reporter gene and testing for effects on expression both prior to and after integration into the chromosomes of K562 cells, a human erythroid cell line. Prior to integration, fragments containing HS2 enhanced expression to the greatest extent, and the modest enhancement by some fragments containing HS3 correlated with the presence of a well-conserved binding site for AP1/NFE2. The stronger effects of larger locus control region DNA fragments in clones of stably transfected cells indicates a role for sequences outside the HS cores after integration into the genome. The strong effect of a 1.9-kilobase HindIII fragment containing HS3 after, but not prior to, integration argues for the presence of a chromatin domain-opening activity. Use of a rabbit DNA fragment containing both HS2 and HS3 demonstrated a synergistic interaction between the two HSs when their natural context and spacing are preserved

The Ursinus Weekly, October 3, 1968

Fourteen join faculty; Dept. heads named for Philos. & Economics • 227 freshmen begin studies; 3 foreign students included • Professors recognized for teaching excellence • Stained glass exhibit on display at Ursinus • Joint effort concert features Intruders • Editorial: Student activism - radical or responsible? • Frosh at Shalom; Dinks on till 12th • The illegalities of Ursinus law • The great society? • Editorial: Everyone\u27s problem • Freeland\u27s days numbered; Library to rise on site • Graduate school aspirants urged to prepare early • Forums replace required chapel • Studio art to highlight new fine arts course • Annual Parents Day planned for Oct. 12 • Franklin & Marshall passing stops Bears in season opener • Ursinus hockey squad hopes for eighth undefeated year • Baker counts on frosh to bolster soccer team • Undefeated Harriers aim for MAC title • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1163/thumbnail.jp

Proteomic approach to identify candidate effector molecules during the in vitro immune exclusion of infective Teladorsagia circumcincta in the abomasum of sheep

International audienceIn the present study we have employed an in vitro organ challenge model to study the post-challenge responses in parasite naïve and immune gastric tissue of sheep, in an attempt to identify the host derived factors involved in immune exclusion of Teladorsagia circumcincta larvae. Proteins present in the epithelial cells and mucus from ovine abomasa following parasite challenge in previously naïve and immune animals were analysed through Matrix Assisted Laser Desorption/Ionization-Time of Flight (MALDI-Tof)-MS and shotgun proteomics. MALDI-ToF analysis of epithelial cell lysates revealed that a number of proteins identified were differentially expressed in naïve and immune cells. These included intelectin and lysozymes, which were present at higher levels in epithelial cell lysates derived from immune samples. A large number of proteins were identified in the mucosal wash from immune tissue which were not present in the mucosal wash of the naïve tissue. Some of these proteins were present in washes of immune tissue prior to the parasite challenge including immunoglobulin A, galectin 14 and 15 and sheep mast cell protease 1. However, other proteins, such as calcium activated chloride channel and intelectin were only detected in the washings from the challenged tissue. The latter may be related to an enhanced mucus release, which may result in entrapment of infective larvae and thus reduced establishment in tissue that has been previously challenged with the parasite. In conclusion, several proteins have been identified which may be involved, either directly or indirectly, in the exclusion and immune elimination of incoming infective larvae. In the present study, the usefulness of the in vitro model has been confirmed, and the global proteomic approach has identified proteins that had not previously been associated with parasite exclusion from abomasal mucosa, such as the calcium activated chloride channel

Trusted CI Experiences in Cybersecurity and Service to Open Science

This article describes experiences and lessons learned from the Trusted CI project, funded by the US National Science Foundation to serve the community as the NSF Cybersecurity Center of Excellence. Trusted CI is an effort to address cybersecurity for the open science community through a single organization that provides leadership, training, consulting, and knowledge to that community. The article describes the experiences and lessons learned of Trusted CI regarding both cybersecurity for open science and managing the process of providing centralized services to a broad and diverse community.Comment: 8 pages, PEARC '19: Practice and Experience in Advanced Research Computing, July 28-August 1, 2019, Chicago, IL, US

Increasing Vaccination Rates of Children up to 24 months old at PMG Milwaukie Family Medicine

Increasing Vaccination Rates of children up to 24 months old at PMG Milwaukie Family Medicine Authors: Justin Ferley DO; Rachel Jackson MD; Aubrey Miller MD; Sebastian Reeve MD; Christelle Serra Van-Brunt DO; Jamie Skreen DO; Jeffrey Sun DO; John Yates MD; Daniel Ruegg MD Introduction: Each year in the US, 42000 adults and 300 children die of vaccine preventable diseases. Yet across the country, clinics – including ours – fall short of the CDC Healthy People 2020 goals of pediatric vaccination rates. This resident-led quality improvement (QI) project aimed to improve our clinic vaccination rates in the under 24mo population. Methods: We identified 3 opportunities for vaccinating children under our clinic current processes: well child visits, medical assistants’ vaccinations visits, and acute care visits. Using a multidisciplinary approach comprising residents, MAs, clinical care coordinators and our nursing quality supervisor, we analyzed our current vaccinations processes and our iterative plan-do-study- cycles (PDSA) included: PDSA #1: standardize our work flow for vaccine reconciliation. PDSA #2: sending personal reminder lebers to patients and overall improving our vaccine recall/ reminder system. PDSA #3: Minimizing provider variation for vaccines given at the 12-18mo WCC. Results: We saw an improvement in our vaccinations rates after personalized reminder letters were sent out, outlining that we do not have a reliable vaccine schedule reminder system. We also noted that different providers created different vaccinations schedules in order to prevent giving 5 vaccines at the same $me – with no system in place to follow on missed vaccination, thus creating missed opportunities and suggesting that we need to implement a clinic-wide vaccine schedule. Conclusion: Our last PDSA cycle was interrupted by current CIVD-19 pandemic. We have however found valuable data to help improve our clinic’s vaccination rates, and plan to continue this project over the next 2 years.https://digitalcommons.psjhealth.org/milwaukie_family/1007/thumbnail.jp

Applying a 6 DoF robotic arm and digital twin to automate fan-blade reconditioning for aerospace maintenance, repair, and overhaul

The UK is home to several major air commercial and transport hubs. As a result, there is a high demand for Maintenance, Repair, and Overhaul (MRO) services to ensure that fleets of aircraft are in airworthy conditions. MRO services currently involve heavy manual labor. This creates bottlenecks, low repeatability, and low productivity. Presented in this paper is an investigation to create an automation cell for the fan-blade reconditioning component of MRO. The design and prototype of the automation cell is presented. Furthermore, a digital twin of the grinding process is developed and used as a tool to explore the required grinding force parameters needed to effectively remove surface material. An integration of a 6-DoF industrial robot with an end-effector grinder and a computer vision system was undertaken. The computer vision system was used for the digitization of the fan-blade surface as well as tracking and guidance of material removal. Our findings reveal that our proposed system can perform material removal, track the state of the fan blade during the reconditioning process and do so within a closed-loop automated robotic work cell

The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice

AbstractBackgroundCerium oxide (CeO2) nanoparticles improve the burning efficiency of fuel, however, little is known about health impacts of altered emissions from the vehicles.MethodsAtherosclerosis-prone apolipoprotein E knockout (ApoE−/−) mice were exposed by inhalation to diluted exhaust (1.7mg/m3, 20, 60 or 180min, 5 day/week, for 4 weeks), from an engine using standard diesel fuel (DE) or the same diesel fuel containing 9ppm cerium oxide nanoparticles (DCeE). Changes in hematological indices, clinical chemistry, atherosclerotic burden, tissue levels of inflammatory cytokines and pathology of the major organs were assessed.ResultsAddition of CeO2 to fuel resulted in a reduction of the number (30%) and surface area (10%) of the particles in the exhaust, whereas the gaseous co-pollutants were increased (6–8%). There was, however, a trend towards an increased size and complexity of the atherosclerotic plaques following DE exposure, which was not evident in the DCeE group. There were no clear signs of altered hematological or pathological changes induced by either treatment. However, levels of proinflammatory cytokines were modulated in a brain region and liver following DCeE exposure.ConclusionsThese results imply that addition of CeO2 nanoparticles to fuel decreases the number of particles in exhaust and may reduce atherosclerotic burden associated with exposure to standard diesel fuel. From the extensive assessment of biological parameters performed, the only concerning effect of cerium addition was a slightly raised level of cytokines in a region of the central nervous system. Overall, the use of cerium as a fuel additive may be a potentially useful way to limit the health effects of vehicle exhaust. However, further testing is required to ensure that such an approach is not associated with a chronic inflammatory response which may eventually cause long-term health effects